Association of thyroid disease with acute leukemia

Craig Moskowitz, Janice P. Dutcher, Peter H. Wiernik

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


The purpose of this paper is to evaluate the possible clinical association of autoimmune thyroid disease and acute leukemia. This study is a retrospective review of all adult patients with acute leukemia treated at our institutions from 1978‐1989. Those with both leukemia and thyroid disease were evaluated and are presented. Twenty‐seven of eight hundred seventy patients with acute leukemia had evidence of thyroid disease. This is a 3‐fold increase in overall incidence. Twenty‐one patients had acute myeloid leukemia, five had acute lymphoid leukemia, and one had accelerated chronic myeloid leukemia. Thyroid diseaseentities included toxic multinodular goiter (four patients), idiopathic hypothyroidism (eight patients), Graves' disease (eight patients), and Hashimoto's thyroiditis (seven patients). Whereas the association may have had a negative effect on elderly patients, those with Graves' disease and Hashimoto's disease appeared to have an improved outcome of the leukemia. There is an increased association of autoimmune thyroid disease and acute leukemia. Since thyroid hormones are important regulators of hematopoiesis and utilize receptors similar to those of differentiating factors such as retinoids, the association may be important for further study of mechanisms of growth regulations in leukemia.

Original languageEnglish (US)
Pages (from-to)102-107
Number of pages6
JournalAmerican Journal of Hematology
Issue number2
StatePublished - Feb 1992
Externally publishedYes


  • acute leukemia
  • thyroid disease
  • thyroiditis

ASJC Scopus subject areas

  • Hematology


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