Association of the apolipoprotein E gene with age-related macular degeneration

possible effect modification by family history, age, and gender.

S. Schmidt, A. M. Saunders, La Paz MA De La Paz MA, E. A. Postel, R. M. Heinis, A. Agarwal, William K Scott, John Gilbert, J. G. McDowell, A. Bazyk, J. D. Gass, J. L. Haines, Margaret A Pericak-Vance

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

PURPOSE: Age-related macular degeneration (AMD) is a complex disorder affecting older adults in which genetic factors are likely to play a role. It has been previously suggested that the e4 allele of the apolipoprotein E (APOE) gene may have a protective effect on AMD risk and that the e2 allele may increase disease risk. The purpose of our study was to examine whether an independent data set would support the proposed role of APOE in AMD etiology. METHODS: We compared AMD cases (n=230) to controls (n=372) with respect to APOE genotypes using c2 tests and logistic regression analysis. We also conducted separate analyses for familial (n=129) and sporadic (n=101) AMD cases since these groups may have a different disease etiology. RESULTS: We did not find evidence for the risk-increasing effect attributed to the e2 allele in either familial or sporadic AMD. No evidence for a protective effect of the e4 allele was obtained for sporadic AMD. The age- and sex-adjusted odds ratio (OR) for e4 carriers among familial AMD cases compared to controls was 0.66 (95% confidence interval: 0.38-1.12, p=0.13). In the subgroup of individuals younger than 70 years of age, an OR of 0.24 (95% confidence interval: 0.08-0.72, p=0.004) was obtained. CONCLUSIONS: Our data modestly support a protective effect of the APOE-e4 allele on AMD risk, but emphasize the need to investigate more thoroughly whether the effect could be restricted to cases with a family history of AMD and whether it varies across age and sex groups.

Original languageEnglish
Pages (from-to)287-293
Number of pages7
JournalMolecular vision [electronic resource]
Volume6
StatePublished - Dec 31 2000
Externally publishedYes

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Macular Degeneration
Apolipoproteins E
Genes
Alleles
Odds Ratio
Confidence Intervals
Apolipoprotein E4
Age Groups
Logistic Models
Genotype
Regression Analysis

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Association of the apolipoprotein E gene with age-related macular degeneration : possible effect modification by family history, age, and gender. / Schmidt, S.; Saunders, A. M.; De La Paz MA, La Paz MA; Postel, E. A.; Heinis, R. M.; Agarwal, A.; Scott, William K; Gilbert, John; McDowell, J. G.; Bazyk, A.; Gass, J. D.; Haines, J. L.; Pericak-Vance, Margaret A.

In: Molecular vision [electronic resource], Vol. 6, 31.12.2000, p. 287-293.

Research output: Contribution to journalArticle

Schmidt, S, Saunders, AM, De La Paz MA, LPMA, Postel, EA, Heinis, RM, Agarwal, A, Scott, WK, Gilbert, J, McDowell, JG, Bazyk, A, Gass, JD, Haines, JL & Pericak-Vance, MA 2000, 'Association of the apolipoprotein E gene with age-related macular degeneration: possible effect modification by family history, age, and gender.', Molecular vision [electronic resource], vol. 6, pp. 287-293.
Schmidt, S. ; Saunders, A. M. ; De La Paz MA, La Paz MA ; Postel, E. A. ; Heinis, R. M. ; Agarwal, A. ; Scott, William K ; Gilbert, John ; McDowell, J. G. ; Bazyk, A. ; Gass, J. D. ; Haines, J. L. ; Pericak-Vance, Margaret A. / Association of the apolipoprotein E gene with age-related macular degeneration : possible effect modification by family history, age, and gender. In: Molecular vision [electronic resource]. 2000 ; Vol. 6. pp. 287-293.
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abstract = "PURPOSE: Age-related macular degeneration (AMD) is a complex disorder affecting older adults in which genetic factors are likely to play a role. It has been previously suggested that the e4 allele of the apolipoprotein E (APOE) gene may have a protective effect on AMD risk and that the e2 allele may increase disease risk. The purpose of our study was to examine whether an independent data set would support the proposed role of APOE in AMD etiology. METHODS: We compared AMD cases (n=230) to controls (n=372) with respect to APOE genotypes using c2 tests and logistic regression analysis. We also conducted separate analyses for familial (n=129) and sporadic (n=101) AMD cases since these groups may have a different disease etiology. RESULTS: We did not find evidence for the risk-increasing effect attributed to the e2 allele in either familial or sporadic AMD. No evidence for a protective effect of the e4 allele was obtained for sporadic AMD. The age- and sex-adjusted odds ratio (OR) for e4 carriers among familial AMD cases compared to controls was 0.66 (95{\%} confidence interval: 0.38-1.12, p=0.13). In the subgroup of individuals younger than 70 years of age, an OR of 0.24 (95{\%} confidence interval: 0.08-0.72, p=0.004) was obtained. CONCLUSIONS: Our data modestly support a protective effect of the APOE-e4 allele on AMD risk, but emphasize the need to investigate more thoroughly whether the effect could be restricted to cases with a family history of AMD and whether it varies across age and sex groups.",
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T1 - Association of the apolipoprotein E gene with age-related macular degeneration

T2 - possible effect modification by family history, age, and gender.

AU - Schmidt, S.

AU - Saunders, A. M.

AU - De La Paz MA, La Paz MA

AU - Postel, E. A.

AU - Heinis, R. M.

AU - Agarwal, A.

AU - Scott, William K

AU - Gilbert, John

AU - McDowell, J. G.

AU - Bazyk, A.

AU - Gass, J. D.

AU - Haines, J. L.

AU - Pericak-Vance, Margaret A

PY - 2000/12/31

Y1 - 2000/12/31

N2 - PURPOSE: Age-related macular degeneration (AMD) is a complex disorder affecting older adults in which genetic factors are likely to play a role. It has been previously suggested that the e4 allele of the apolipoprotein E (APOE) gene may have a protective effect on AMD risk and that the e2 allele may increase disease risk. The purpose of our study was to examine whether an independent data set would support the proposed role of APOE in AMD etiology. METHODS: We compared AMD cases (n=230) to controls (n=372) with respect to APOE genotypes using c2 tests and logistic regression analysis. We also conducted separate analyses for familial (n=129) and sporadic (n=101) AMD cases since these groups may have a different disease etiology. RESULTS: We did not find evidence for the risk-increasing effect attributed to the e2 allele in either familial or sporadic AMD. No evidence for a protective effect of the e4 allele was obtained for sporadic AMD. The age- and sex-adjusted odds ratio (OR) for e4 carriers among familial AMD cases compared to controls was 0.66 (95% confidence interval: 0.38-1.12, p=0.13). In the subgroup of individuals younger than 70 years of age, an OR of 0.24 (95% confidence interval: 0.08-0.72, p=0.004) was obtained. CONCLUSIONS: Our data modestly support a protective effect of the APOE-e4 allele on AMD risk, but emphasize the need to investigate more thoroughly whether the effect could be restricted to cases with a family history of AMD and whether it varies across age and sex groups.

AB - PURPOSE: Age-related macular degeneration (AMD) is a complex disorder affecting older adults in which genetic factors are likely to play a role. It has been previously suggested that the e4 allele of the apolipoprotein E (APOE) gene may have a protective effect on AMD risk and that the e2 allele may increase disease risk. The purpose of our study was to examine whether an independent data set would support the proposed role of APOE in AMD etiology. METHODS: We compared AMD cases (n=230) to controls (n=372) with respect to APOE genotypes using c2 tests and logistic regression analysis. We also conducted separate analyses for familial (n=129) and sporadic (n=101) AMD cases since these groups may have a different disease etiology. RESULTS: We did not find evidence for the risk-increasing effect attributed to the e2 allele in either familial or sporadic AMD. No evidence for a protective effect of the e4 allele was obtained for sporadic AMD. The age- and sex-adjusted odds ratio (OR) for e4 carriers among familial AMD cases compared to controls was 0.66 (95% confidence interval: 0.38-1.12, p=0.13). In the subgroup of individuals younger than 70 years of age, an OR of 0.24 (95% confidence interval: 0.08-0.72, p=0.004) was obtained. CONCLUSIONS: Our data modestly support a protective effect of the APOE-e4 allele on AMD risk, but emphasize the need to investigate more thoroughly whether the effect could be restricted to cases with a family history of AMD and whether it varies across age and sex groups.

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