Association of T Cell Proliferative Responses and Phenotype with Virus Control in Chronic Progressive HIV-1 Disease

Uma Malhotra, Ronald J. Bosch, Ellen Chan, Rui Wang, Margaret A. Fischl, Ann C. Collier, M. Juliana McElrath

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The role of T cell immunity in virus control during chronic infection was examined in 79 human immunodeficiency virus type 1 (HIV-1)-infected subjects randomized to receive antiretroviral therapy. HIV-1 p24-specific responses were detected in 20% of the subjects at baseline, increasing to 28% of the subjects at weeks 16-24. Induction of virologic suppression was associated with lower plasma HIV-1 RNA levels and a higher percentage of Fas+ CD8 + T cells at baseline, whereas maintenance of suppression was associated with higher CD4+ T cell counts and, marginally, with a higher percentage of Fas+ CD4+ T cells at weeks 16-24. These findings indicate that Fas coexpression on T cells, in addition to plasma HIV-1 RNA levels and CD4+ T cell counts, may predict virologic outcome.

Original languageEnglish (US)
Pages (from-to)515-519
Number of pages5
JournalJournal of Infectious Diseases
Volume189
Issue number3
DOIs
StatePublished - Feb 1 2004

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Association of T Cell Proliferative Responses and Phenotype with Virus Control in Chronic Progressive HIV-1 Disease'. Together they form a unique fingerprint.

  • Cite this