Association of T Cell Proliferative Responses and Phenotype with Virus Control in Chronic Progressive HIV-1 Disease

Uma Malhotra, Ronald J. Bosch, Ellen Chan, Rui Wang, Margaret A Fischl, Ann C. Collier, M. Juliana McElrath

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The role of T cell immunity in virus control during chronic infection was examined in 79 human immunodeficiency virus type 1 (HIV-1)-infected subjects randomized to receive antiretroviral therapy. HIV-1 p24-specific responses were detected in 20% of the subjects at baseline, increasing to 28% of the subjects at weeks 16-24. Induction of virologic suppression was associated with lower plasma HIV-1 RNA levels and a higher percentage of Fas+ CD8 + T cells at baseline, whereas maintenance of suppression was associated with higher CD4+ T cell counts and, marginally, with a higher percentage of Fas+ CD4+ T cells at weeks 16-24. These findings indicate that Fas coexpression on T cells, in addition to plasma HIV-1 RNA levels and CD4+ T cell counts, may predict virologic outcome.

Original languageEnglish
Pages (from-to)515-519
Number of pages5
JournalJournal of Infectious Diseases
Volume189
Issue number3
DOIs
StatePublished - Feb 1 2004

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Virus Diseases
HIV-1
Viruses
T-Lymphocytes
Phenotype
CD4 Lymphocyte Count
RNA
Immunity
Maintenance
Infection

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Association of T Cell Proliferative Responses and Phenotype with Virus Control in Chronic Progressive HIV-1 Disease. / Malhotra, Uma; Bosch, Ronald J.; Chan, Ellen; Wang, Rui; Fischl, Margaret A; Collier, Ann C.; McElrath, M. Juliana.

In: Journal of Infectious Diseases, Vol. 189, No. 3, 01.02.2004, p. 515-519.

Research output: Contribution to journalArticle

Malhotra, Uma ; Bosch, Ronald J. ; Chan, Ellen ; Wang, Rui ; Fischl, Margaret A ; Collier, Ann C. ; McElrath, M. Juliana. / Association of T Cell Proliferative Responses and Phenotype with Virus Control in Chronic Progressive HIV-1 Disease. In: Journal of Infectious Diseases. 2004 ; Vol. 189, No. 3. pp. 515-519.
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