Association of T Cell Proliferative Responses and Phenotype with Virus Control in Chronic Progressive HIV-1 Disease

Uma Malhotra; Ronald J. Bosch; Ellen Chan; Rui Wang; Margaret A. Fischl; Ann C. Collier; M. Juliana McElrath

doi:10.1086/381038

Association of T Cell Proliferative Responses and Phenotype with Virus Control in Chronic Progressive HIV-1 Disease

Uma Malhotra, Ronald J. Bosch, Ellen Chan, Rui Wang, Margaret A. Fischl, Ann C. Collier, M. Juliana McElrath

Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The role of T cell immunity in virus control during chronic infection was examined in 79 human immunodeficiency virus type 1 (HIV-1)-infected subjects randomized to receive antiretroviral therapy. HIV-1 p24-specific responses were detected in 20% of the subjects at baseline, increasing to 28% of the subjects at weeks 16-24. Induction of virologic suppression was associated with lower plasma HIV-1 RNA levels and a higher percentage of Fas⁺ CD8 ⁺ T cells at baseline, whereas maintenance of suppression was associated with higher CD4⁺ T cell counts and, marginally, with a higher percentage of Fas⁺ CD4⁺ T cells at weeks 16-24. These findings indicate that Fas coexpression on T cells, in addition to plasma HIV-1 RNA levels and CD4⁺ T cell counts, may predict virologic outcome.

Original language	English (US)
Pages (from-to)	515-519
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	189
Issue number	3
DOIs	https://doi.org/10.1086/381038
State	Published - Feb 1 2004

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

Access to Document

10.1086/381038

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Association of T Cell Proliferative Responses and Phenotype with Virus Control in Chronic Progressive HIV-1 Disease. / Malhotra, Uma; Bosch, Ronald J.; Chan, Ellen; Wang, Rui; Fischl, Margaret A.; Collier, Ann C.; McElrath, M. Juliana.

In: Journal of Infectious Diseases, Vol. 189, No. 3, 01.02.2004, p. 515-519.

Research output: Contribution to journal › Article › peer-review

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abstract = "The role of T cell immunity in virus control during chronic infection was examined in 79 human immunodeficiency virus type 1 (HIV-1)-infected subjects randomized to receive antiretroviral therapy. HIV-1 p24-specific responses were detected in 20% of the subjects at baseline, increasing to 28% of the subjects at weeks 16-24. Induction of virologic suppression was associated with lower plasma HIV-1 RNA levels and a higher percentage of Fas+ CD8 + T cells at baseline, whereas maintenance of suppression was associated with higher CD4+ T cell counts and, marginally, with a higher percentage of Fas+ CD4+ T cells at weeks 16-24. These findings indicate that Fas coexpression on T cells, in addition to plasma HIV-1 RNA levels and CD4+ T cell counts, may predict virologic outcome.",

author = "Uma Malhotra and Bosch, {Ronald J.} and Ellen Chan and Rui Wang and Fischl, {Margaret A.} and Collier, {Ann C.} and McElrath, {M. Juliana}",

note = "Funding Information: Received 19 May 2003; accepted 8 August 2003; electronically published 16 January 2004. Presented in part: Keystone Symposium, Twenty Years of HIV Research: From Discovery to Understanding, Banff, Alberta, Canada, 28 March–3 April 2003 (abstract 318). Financial support: National Institutes of Health (grants AI-41535, AI-01411, AI-27757, AI-38855, AI-27675 and AI-27664); Burroughs Wellcome Foundation. Reprints or correspondence: Dr. Uma Malhotra, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N, D3-100, Seattle, WA 98109 (uma@u.washington.edu).",

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