Abstract
The role of T cell immunity in virus control during chronic infection was examined in 79 human immunodeficiency virus type 1 (HIV-1)-infected subjects randomized to receive antiretroviral therapy. HIV-1 p24-specific responses were detected in 20% of the subjects at baseline, increasing to 28% of the subjects at weeks 16-24. Induction of virologic suppression was associated with lower plasma HIV-1 RNA levels and a higher percentage of Fas+ CD8 + T cells at baseline, whereas maintenance of suppression was associated with higher CD4+ T cell counts and, marginally, with a higher percentage of Fas+ CD4+ T cells at weeks 16-24. These findings indicate that Fas coexpression on T cells, in addition to plasma HIV-1 RNA levels and CD4+ T cell counts, may predict virologic outcome.
Original language | English (US) |
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Pages (from-to) | 515-519 |
Number of pages | 5 |
Journal | Journal of Infectious Diseases |
Volume | 189 |
Issue number | 3 |
DOIs | |
State | Published - Feb 1 2004 |
ASJC Scopus subject areas
- Immunology and Allergy
- Infectious Diseases