Abstract
The role of T cell immunity in virus control during chronic infection was examined in 79 human immunodeficiency virus type 1 (HIV-1)-infected subjects randomized to receive antiretroviral therapy. HIV-1 p24-specific responses were detected in 20% of the subjects at baseline, increasing to 28% of the subjects at weeks 16-24. Induction of virologic suppression was associated with lower plasma HIV-1 RNA levels and a higher percentage of Fas+ CD8 + T cells at baseline, whereas maintenance of suppression was associated with higher CD4+ T cell counts and, marginally, with a higher percentage of Fas+ CD4+ T cells at weeks 16-24. These findings indicate that Fas coexpression on T cells, in addition to plasma HIV-1 RNA levels and CD4+ T cell counts, may predict virologic outcome.
| Original language | English |
|---|---|
| Pages (from-to) | 515-519 |
| Number of pages | 5 |
| Journal | Journal of Infectious Diseases |
| Volume | 189 |
| Issue number | 3 |
| DOIs | |
| State | Published - Feb 1 2004 |
Fingerprint
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Immunology
Cite this
Association of T Cell Proliferative Responses and Phenotype with Virus Control in Chronic Progressive HIV-1 Disease. / Malhotra, Uma; Bosch, Ronald J.; Chan, Ellen; Wang, Rui; Fischl, Margaret A; Collier, Ann C.; McElrath, M. Juliana.
In: Journal of Infectious Diseases, Vol. 189, No. 3, 01.02.2004, p. 515-519.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association of T Cell Proliferative Responses and Phenotype with Virus Control in Chronic Progressive HIV-1 Disease
AU - Malhotra, Uma
AU - Bosch, Ronald J.
AU - Chan, Ellen
AU - Wang, Rui
AU - Fischl, Margaret A
AU - Collier, Ann C.
AU - McElrath, M. Juliana
PY - 2004/2/1
Y1 - 2004/2/1
N2 - The role of T cell immunity in virus control during chronic infection was examined in 79 human immunodeficiency virus type 1 (HIV-1)-infected subjects randomized to receive antiretroviral therapy. HIV-1 p24-specific responses were detected in 20% of the subjects at baseline, increasing to 28% of the subjects at weeks 16-24. Induction of virologic suppression was associated with lower plasma HIV-1 RNA levels and a higher percentage of Fas+ CD8 + T cells at baseline, whereas maintenance of suppression was associated with higher CD4+ T cell counts and, marginally, with a higher percentage of Fas+ CD4+ T cells at weeks 16-24. These findings indicate that Fas coexpression on T cells, in addition to plasma HIV-1 RNA levels and CD4+ T cell counts, may predict virologic outcome.
AB - The role of T cell immunity in virus control during chronic infection was examined in 79 human immunodeficiency virus type 1 (HIV-1)-infected subjects randomized to receive antiretroviral therapy. HIV-1 p24-specific responses were detected in 20% of the subjects at baseline, increasing to 28% of the subjects at weeks 16-24. Induction of virologic suppression was associated with lower plasma HIV-1 RNA levels and a higher percentage of Fas+ CD8 + T cells at baseline, whereas maintenance of suppression was associated with higher CD4+ T cell counts and, marginally, with a higher percentage of Fas+ CD4+ T cells at weeks 16-24. These findings indicate that Fas coexpression on T cells, in addition to plasma HIV-1 RNA levels and CD4+ T cell counts, may predict virologic outcome.
UR - http://www.scopus.com/inward/record.url?scp=1142309468&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1142309468&partnerID=8YFLogxK
U2 - 10.1086/381038
DO - 10.1086/381038
M3 - Article
C2 - 14745710
AN - SCOPUS:1142309468
VL - 189
SP - 515
EP - 519
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 3
ER -