Association of serum uric acid with incident atrial fibrillation (from the Atherosclerosis Risk in Communities [ARIC] study)

Leonardo Tamariz, Sunil Agarwal, Elsayed Z. Soliman, Alanna M. Chamberlain, Ronald Prineas, Aaron R. Folsom, Marietta Ambrose, Alvaro Alonso

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Atrial fibrillation (AF) is one of the most common arrhythmias seen in clinical practice. Current evidence suggests that serum uric acid (SUA) could be a marker of oxidative damage, a factor reported as a part of the mechanisms of AF. The purpose of the present study was to evaluate whether SUA predicted AF in the Atherosclerosis Risk In Communities (ARIC) study. The present analysis included 15,382 AF-free black and white men and women, aged 45 to 64 years, from the ARIC study, a population-based prospective cohort in the United States. SUA was determined using the uricase-peroxidase method at baseline. The primary outcome was the incidence of AF, defined as the occurrence of AF detected using hospital discharge codes, scheduled study electrocardiograms, and/or death certificates during the follow-up period (1987 to 2004). We identified 1,085 cases of incident AF. In Cox proportional hazards models adjusted for age, gender, race, center, education, body mass index, serum glucose, systolic and diastolic blood pressure, low-density lipoprotein cholesterol, alcohol use, prevalent coronary heart disease and heart failure, serum creatinine, diuretics, and P-wave duration on the electrocardiogram (as a measure of left atrial size) at baseline, the hazard ratio of AF associated with a SD increment in SUA was 1.16 (95% confidence interval 1.06 to 1.26). The association of SUA with AF risk differed by race and gender (p for interaction <0.01). In conclusion, elevated SUA is associated with a greater risk of AF, particularly among blacks and women. Additional studies should replicate this association and explore potential mechanisms.

Original languageEnglish
Pages (from-to)1272-1276
Number of pages5
JournalAmerican Journal of Cardiology
Volume108
Issue number9
DOIs
StatePublished - Nov 1 2011

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Uric Acid
Atrial Fibrillation
Atherosclerosis
Serum
Electrocardiography
Urate Oxidase
Blood Pressure
Death Certificates
Proportional Hazards Models
Diuretics
LDL Cholesterol
Peroxidase
Coronary Disease
Cardiac Arrhythmias
Creatinine
Body Mass Index
Heart Failure
Alcohols
Confidence Intervals
Education

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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Association of serum uric acid with incident atrial fibrillation (from the Atherosclerosis Risk in Communities [ARIC] study). / Tamariz, Leonardo; Agarwal, Sunil; Soliman, Elsayed Z.; Chamberlain, Alanna M.; Prineas, Ronald; Folsom, Aaron R.; Ambrose, Marietta; Alonso, Alvaro.

In: American Journal of Cardiology, Vol. 108, No. 9, 01.11.2011, p. 1272-1276.

Research output: Contribution to journalArticle

Tamariz, Leonardo ; Agarwal, Sunil ; Soliman, Elsayed Z. ; Chamberlain, Alanna M. ; Prineas, Ronald ; Folsom, Aaron R. ; Ambrose, Marietta ; Alonso, Alvaro. / Association of serum uric acid with incident atrial fibrillation (from the Atherosclerosis Risk in Communities [ARIC] study). In: American Journal of Cardiology. 2011 ; Vol. 108, No. 9. pp. 1272-1276.
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