Abstract
Objective: To examine the cardiovascular risk factors in patients with psoriasis and the association between psoriasis and coronary artery, cerebrovascular, and peripheral vascular diseases. Design: Observational study. Setting: Large Department of Veterans Affairs hospital. Patients: The study included 3236 patients with psoriasis and 2500 patients without psoriasis (controls). Main Outcome Measures: Using International Classification of Diseases, Ninth Revision, Clinical Modification, codes, we compared the prevalence of traditional cardiovascular risk factors and other vascular diseases as well as mortality between patients with psoriasis and controls. Results: Similar to previous studies, we found a higher prevalence of diabetes mellitus, hypertension, dyslipidemia, and smoking in patients with psoriasis. After controlling for these variables, we found a higher prevalence not only of ischemic heart disease (odds ratio [OR], 1.78; 95% confidence interval [CI], 1.51-2.11) but also of cerebrovascular (OR, 1.70; 95% CI, 1.33-2.17) and peripheral vascular (OR, 1.98; 95% CI, 1.32-2.82) diseases in patients with psoriasis compared with controls. Psoriasis was also found to be an independent risk factor for mortality (OR, 1.86; 95% CI, 1.56-2.21). Conclusions: Psoriasis is associated with atherosclerosis. This association applies to coronary artery, cerebrovascular, and peripheral vascular diseases and results in increased mortality.
| Original language | English |
|---|---|
| Pages (from-to) | 700-703 |
| Number of pages | 4 |
| Journal | Archives of Dermatology |
| Volume | 145 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1 2009 |
Fingerprint
ASJC Scopus subject areas
- Dermatology
Cite this
Association of psoriasis with coronary artery, cerebrovascular, and peripheral vascular diseases and mortality. / Prodanovich, Srjdan; Kirsner, Robert; Kravetz, Jeffrey D.; Ma, Fangchao; Martinez, Lisa; Federman, Daniel G.
In: Archives of Dermatology, Vol. 145, No. 6, 01.06.2009, p. 700-703.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association of psoriasis with coronary artery, cerebrovascular, and peripheral vascular diseases and mortality
AU - Prodanovich, Srjdan
AU - Kirsner, Robert
AU - Kravetz, Jeffrey D.
AU - Ma, Fangchao
AU - Martinez, Lisa
AU - Federman, Daniel G.
PY - 2009/6/1
Y1 - 2009/6/1
N2 - Objective: To examine the cardiovascular risk factors in patients with psoriasis and the association between psoriasis and coronary artery, cerebrovascular, and peripheral vascular diseases. Design: Observational study. Setting: Large Department of Veterans Affairs hospital. Patients: The study included 3236 patients with psoriasis and 2500 patients without psoriasis (controls). Main Outcome Measures: Using International Classification of Diseases, Ninth Revision, Clinical Modification, codes, we compared the prevalence of traditional cardiovascular risk factors and other vascular diseases as well as mortality between patients with psoriasis and controls. Results: Similar to previous studies, we found a higher prevalence of diabetes mellitus, hypertension, dyslipidemia, and smoking in patients with psoriasis. After controlling for these variables, we found a higher prevalence not only of ischemic heart disease (odds ratio [OR], 1.78; 95% confidence interval [CI], 1.51-2.11) but also of cerebrovascular (OR, 1.70; 95% CI, 1.33-2.17) and peripheral vascular (OR, 1.98; 95% CI, 1.32-2.82) diseases in patients with psoriasis compared with controls. Psoriasis was also found to be an independent risk factor for mortality (OR, 1.86; 95% CI, 1.56-2.21). Conclusions: Psoriasis is associated with atherosclerosis. This association applies to coronary artery, cerebrovascular, and peripheral vascular diseases and results in increased mortality.
AB - Objective: To examine the cardiovascular risk factors in patients with psoriasis and the association between psoriasis and coronary artery, cerebrovascular, and peripheral vascular diseases. Design: Observational study. Setting: Large Department of Veterans Affairs hospital. Patients: The study included 3236 patients with psoriasis and 2500 patients without psoriasis (controls). Main Outcome Measures: Using International Classification of Diseases, Ninth Revision, Clinical Modification, codes, we compared the prevalence of traditional cardiovascular risk factors and other vascular diseases as well as mortality between patients with psoriasis and controls. Results: Similar to previous studies, we found a higher prevalence of diabetes mellitus, hypertension, dyslipidemia, and smoking in patients with psoriasis. After controlling for these variables, we found a higher prevalence not only of ischemic heart disease (odds ratio [OR], 1.78; 95% confidence interval [CI], 1.51-2.11) but also of cerebrovascular (OR, 1.70; 95% CI, 1.33-2.17) and peripheral vascular (OR, 1.98; 95% CI, 1.32-2.82) diseases in patients with psoriasis compared with controls. Psoriasis was also found to be an independent risk factor for mortality (OR, 1.86; 95% CI, 1.56-2.21). Conclusions: Psoriasis is associated with atherosclerosis. This association applies to coronary artery, cerebrovascular, and peripheral vascular diseases and results in increased mortality.
UR - http://www.scopus.com/inward/record.url?scp=67449110958&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67449110958&partnerID=8YFLogxK
U2 - 10.1001/archdermatol.2009.94
DO - 10.1001/archdermatol.2009.94
M3 - Article
C2 - 19528427
AN - SCOPUS:67449110958
VL - 145
SP - 700
EP - 703
JO - JAMA Dermatology
JF - JAMA Dermatology
SN - 2168-6068
IS - 6
ER -