Association of polymorphisms in the apolipoprotein E region with susceptibility to and progression of multiple sclerosis

Silke Schmidt, Lisa F. Barcellos, Karen DeSombre, Jacqueline B. Rimmler, Robin R. Lincoln, Patricia Bucher, Ann M. Saunders, Eric Lai, Eden R Martin, Jeffery M Vance, Jorge R. Oksenberg, Stephen L. Hauser, Margaret A Pericak-Vance, Jonathan L. Haines

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system, with a complex etiology that includes a strong genetic component. The contribution of the major histocompatibility complex (MHC) has been established in numerous genetic linkage and association studies. In addition to the MHC, the chromosome 19q13 region surrounding the apolipoprotein E (APOE) gene has shown consistent evidence of involvement in MS when family-based analyses were conducted. Furthermore, several clinical reports have suggested that the APOE-4 allele may be associated with more-severe disease and faster progression of disability. To thoroughly examine the role of APOE in MS, we genotyped its functional alleles, as well as seven single-nucleotide polymorphisms (SNPs) located primarily within 13 kb of APOE, in a data set of 398 families. Using family-based association analysis, we found statistically significant evidence that an SNP haplotype near APOE is associated with MS susceptibility (P = .005). An analysis of disease progression in 614 patients with MS from 379 families indicated that APOE-4 carriers are more likely to be affected with severe disease (P = .03), whereas a higher proportion of APOE-2 carriers exhibit a mild disease course (P = .02).

Original languageEnglish
Pages (from-to)708-717
Number of pages10
JournalAmerican Journal of Human Genetics
Volume70
Issue number3
DOIs
StatePublished - Mar 9 2002
Externally publishedYes

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Apolipoproteins E
Multiple Sclerosis
Apolipoprotein E4
Major Histocompatibility Complex
Single Nucleotide Polymorphism
Disease Progression
Alleles
Apolipoprotein E2
Genetic Linkage
Central Nervous System Diseases
Genetic Association Studies
Haplotypes
Chromosomes
Genes

ASJC Scopus subject areas

  • Genetics

Cite this

Schmidt, S., Barcellos, L. F., DeSombre, K., Rimmler, J. B., Lincoln, R. R., Bucher, P., ... Haines, J. L. (2002). Association of polymorphisms in the apolipoprotein E region with susceptibility to and progression of multiple sclerosis. American Journal of Human Genetics, 70(3), 708-717. https://doi.org/10.1086/339269

Association of polymorphisms in the apolipoprotein E region with susceptibility to and progression of multiple sclerosis. / Schmidt, Silke; Barcellos, Lisa F.; DeSombre, Karen; Rimmler, Jacqueline B.; Lincoln, Robin R.; Bucher, Patricia; Saunders, Ann M.; Lai, Eric; Martin, Eden R; Vance, Jeffery M; Oksenberg, Jorge R.; Hauser, Stephen L.; Pericak-Vance, Margaret A; Haines, Jonathan L.

In: American Journal of Human Genetics, Vol. 70, No. 3, 09.03.2002, p. 708-717.

Research output: Contribution to journalArticle

Schmidt, S, Barcellos, LF, DeSombre, K, Rimmler, JB, Lincoln, RR, Bucher, P, Saunders, AM, Lai, E, Martin, ER, Vance, JM, Oksenberg, JR, Hauser, SL, Pericak-Vance, MA & Haines, JL 2002, 'Association of polymorphisms in the apolipoprotein E region with susceptibility to and progression of multiple sclerosis', American Journal of Human Genetics, vol. 70, no. 3, pp. 708-717. https://doi.org/10.1086/339269
Schmidt, Silke ; Barcellos, Lisa F. ; DeSombre, Karen ; Rimmler, Jacqueline B. ; Lincoln, Robin R. ; Bucher, Patricia ; Saunders, Ann M. ; Lai, Eric ; Martin, Eden R ; Vance, Jeffery M ; Oksenberg, Jorge R. ; Hauser, Stephen L. ; Pericak-Vance, Margaret A ; Haines, Jonathan L. / Association of polymorphisms in the apolipoprotein E region with susceptibility to and progression of multiple sclerosis. In: American Journal of Human Genetics. 2002 ; Vol. 70, No. 3. pp. 708-717.
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