TY - JOUR
T1 - Association of occupational exposures with cardiovascular disease among US Hispanics/Latinos
AU - Bulka, Catherine M.
AU - Daviglus, Martha L.
AU - Persky, Victoria W.
AU - Durazo-Arvizu, Ramon A.
AU - Lash, James P.
AU - Elfassy, Tali
AU - Lee, David J.
AU - Ramos, Alberto R.
AU - Tarraf, Wassim
AU - Argos, Maria
N1 - Funding Information:
Funding cMB was supported by the national heart, lung, and Blood institute (nhlBi) t32-hl125294. the hispanic community health study/study of latinos was carried out as a collaborative study supported by contracts from the nhlBi to the University of north carolina (n01-hc65233), University of Miami (n01-hc65234), albert einstein college of Medicine (n01-hc65235), University of illinois at chicago (hhsn268201300003i), northwestern University (n01-hc65236) and san Diego state University (n01-hc65237). the following institutes/centres/offices contribute to the hchs/sOl through a transfer of funds to the nhlBi: national institute on Minority health and health Disparities, national institute on Deafness and Other communication Disorders, national institute of Dental and craniofacial research, national institute of Diabetes and Digestive and Kidney Diseases, national institute of neurological Disorders and stroke and nih institution-Office of Dietary supplements.
PY - 2019/3/1
Y1 - 2019/3/1
N2 - Objective Cardiovascular disease (CVD) is a leading cause of mortality and morbidity in the USA. The role of occupational exposures to chemicals in the development of CVD has rarely been studied even though many agents possess cardiotoxic properties. We therefore evaluated associations of self-reported exposures to organic solvents, metals and pesticides in relation to CVD prevalence among diverse Hispanic/Latino workers. Methods Cross-sectional data from 7404 employed individuals, aged 18-74 years, enrolled in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) were analysed. Participants from four US cities provided questionnaire data and underwent clinical examinations, including ECGs. CVD was defined as the presence of at least one of the following: Coronary heart disease, atrial fibrillation, heart failure or cerebrovascular disease. Prevalence ratios reflecting the relationship between each occupational exposure and CVD as well as CVD subtypes were calculated using Poisson regression models. Results Hispanic/Latino workers reported exposures to organic solvents (6.5%), metals (8.5%) and pesticides (4.7%) at their current jobs. Overall, 6.1% of participants had some form of CVD, with coronary heart disease as the most common (4.3%) followed by cerebrovascular disease (1.0%), heart failure (0.8%) and atrial fibrillation (0.7%). For individuals who reported working with pesticides, the prevalence ratios for any CVD were 2.18 (95% CI 1.34 to 3.55), coronary heart disease 2.20 (95% CI 1.31 to 3.71), cerebrovascular disease 1.38 (95% CI 0.62 3.03), heart failure 0.91 (95% CI 0.23 to 3.54) and atrial fibrillation 5.92 (95% CI 1.89 to 18.61) after adjustment for sociodemographic, acculturation, lifestyle and occupational characteristics. Metal exposures were associated with an almost fourfold (3.78, 95% CI 1.24 to 11.46) greater prevalence of atrial fibrillation. Null associations were observed for organic solvent exposures. Conclusions Our results suggest that working with metals and pesticides could be risk factors for CVD among Hispanic/Latino workers. Further work is needed to evaluate these relationships prospectively.
AB - Objective Cardiovascular disease (CVD) is a leading cause of mortality and morbidity in the USA. The role of occupational exposures to chemicals in the development of CVD has rarely been studied even though many agents possess cardiotoxic properties. We therefore evaluated associations of self-reported exposures to organic solvents, metals and pesticides in relation to CVD prevalence among diverse Hispanic/Latino workers. Methods Cross-sectional data from 7404 employed individuals, aged 18-74 years, enrolled in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) were analysed. Participants from four US cities provided questionnaire data and underwent clinical examinations, including ECGs. CVD was defined as the presence of at least one of the following: Coronary heart disease, atrial fibrillation, heart failure or cerebrovascular disease. Prevalence ratios reflecting the relationship between each occupational exposure and CVD as well as CVD subtypes were calculated using Poisson regression models. Results Hispanic/Latino workers reported exposures to organic solvents (6.5%), metals (8.5%) and pesticides (4.7%) at their current jobs. Overall, 6.1% of participants had some form of CVD, with coronary heart disease as the most common (4.3%) followed by cerebrovascular disease (1.0%), heart failure (0.8%) and atrial fibrillation (0.7%). For individuals who reported working with pesticides, the prevalence ratios for any CVD were 2.18 (95% CI 1.34 to 3.55), coronary heart disease 2.20 (95% CI 1.31 to 3.71), cerebrovascular disease 1.38 (95% CI 0.62 3.03), heart failure 0.91 (95% CI 0.23 to 3.54) and atrial fibrillation 5.92 (95% CI 1.89 to 18.61) after adjustment for sociodemographic, acculturation, lifestyle and occupational characteristics. Metal exposures were associated with an almost fourfold (3.78, 95% CI 1.24 to 11.46) greater prevalence of atrial fibrillation. Null associations were observed for organic solvent exposures. Conclusions Our results suggest that working with metals and pesticides could be risk factors for CVD among Hispanic/Latino workers. Further work is needed to evaluate these relationships prospectively.
KW - cardiac risk factors and prevention
KW - epidemiology
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U2 - 10.1136/heartjnl-2018-313463
DO - 10.1136/heartjnl-2018-313463
M3 - Article
C2 - 30538094
AN - SCOPUS:85058302112
VL - 105
SP - 439
EP - 448
JO - Heart
JF - Heart
SN - 1355-6037
IS - 6
ER -