Association of occupational exposures with cardiovascular disease among US Hispanics/Latinos

Catherine M. Bulka, Martha L. Daviglus, Victoria W. Persky, Ramon A. Durazo-Arvizu, James P. Lash, Tali Elfassy, David J Lee, Alberto Ramos, Wassim Tarraf, Maria Argos

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: Cardiovascular disease (CVD) is a leading cause of mortality and morbidity in the USA. The role of occupational exposures to chemicals in the development of CVD has rarely been studied even though many agents possess cardiotoxic properties. We therefore evaluated associations of self-reported exposures to organic solvents, metals and pesticides in relation to CVD prevalence among diverse Hispanic/Latino workers. Methods: Cross-sectional data from 7404 employed individuals, aged 18-74 years, enrolled in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) were analysed. Participants from four US cities provided questionnaire data and underwent clinical examinations, including ECGs. CVD was defined as the presence of at least one of the following: coronary heart disease, atrial fibrillation, heart failure or cerebrovascular disease. Prevalence ratios reflecting the relationship between each occupational exposure and CVD as well as CVD subtypes were calculated using Poisson regression models. Results: Hispanic/Latino workers reported exposures to organic solvents (6.5%), metals (8.5%) and pesticides (4.7%) at their current jobs. Overall, 6.1% of participants had some form of CVD, with coronary heart disease as the most common (4.3%) followed by cerebrovascular disease (1.0%), heart failure (0.8%) and atrial fibrillation (0.7%). For individuals who reported working with pesticides, the prevalence ratios for any CVD were 2.18 (95% CI 1.34 to 3.55), coronary heart disease 2.20 (95% CI 1.31 to 3.71), cerebrovascular disease 1.38 (95% CI 0.62 3.03), heart failure 0.91 (95% CI 0.23 to 3.54) and atrial fibrillation 5.92 (95% CI 1.89 to 18.61) after adjustment for sociodemographic, acculturation, lifestyle and occupational characteristics. Metal exposures were associated with an almost fourfold (3.78, 95% CI 1.24 to 11.46) greater prevalence of atrial fibrillation. Null associations were observed for organic solvent exposures. Conclusions: Our results suggest that working with metals and pesticides could be risk factors for CVD among Hispanic/Latino workers. Further work is needed to evaluate these relationships prospectively.

Original languageEnglish (US)
JournalHeart
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Occupational Exposure
Hispanic Americans
Cardiovascular Diseases
Cerebrovascular Disorders
Pesticides
Atrial Fibrillation
Metals
Coronary Disease
Heart Failure
Cardiotoxins
Acculturation
Occupational Diseases
Life Style
Heart Diseases
Electrocardiography
Morbidity
Mortality
Health

Keywords

  • cardiac risk factors and prevention
  • epidemiology

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Bulka, C. M., Daviglus, M. L., Persky, V. W., Durazo-Arvizu, R. A., Lash, J. P., Elfassy, T., ... Argos, M. (Accepted/In press). Association of occupational exposures with cardiovascular disease among US Hispanics/Latinos. Heart. https://doi.org/10.1136/heartjnl-2018-313463

Association of occupational exposures with cardiovascular disease among US Hispanics/Latinos. / Bulka, Catherine M.; Daviglus, Martha L.; Persky, Victoria W.; Durazo-Arvizu, Ramon A.; Lash, James P.; Elfassy, Tali; Lee, David J; Ramos, Alberto; Tarraf, Wassim; Argos, Maria.

In: Heart, 01.01.2018.

Research output: Contribution to journalArticle

Bulka, CM, Daviglus, ML, Persky, VW, Durazo-Arvizu, RA, Lash, JP, Elfassy, T, Lee, DJ, Ramos, A, Tarraf, W & Argos, M 2018, 'Association of occupational exposures with cardiovascular disease among US Hispanics/Latinos', Heart. https://doi.org/10.1136/heartjnl-2018-313463
Bulka CM, Daviglus ML, Persky VW, Durazo-Arvizu RA, Lash JP, Elfassy T et al. Association of occupational exposures with cardiovascular disease among US Hispanics/Latinos. Heart. 2018 Jan 1. https://doi.org/10.1136/heartjnl-2018-313463
Bulka, Catherine M. ; Daviglus, Martha L. ; Persky, Victoria W. ; Durazo-Arvizu, Ramon A. ; Lash, James P. ; Elfassy, Tali ; Lee, David J ; Ramos, Alberto ; Tarraf, Wassim ; Argos, Maria. / Association of occupational exposures with cardiovascular disease among US Hispanics/Latinos. In: Heart. 2018.
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abstract = "Objective: Cardiovascular disease (CVD) is a leading cause of mortality and morbidity in the USA. The role of occupational exposures to chemicals in the development of CVD has rarely been studied even though many agents possess cardiotoxic properties. We therefore evaluated associations of self-reported exposures to organic solvents, metals and pesticides in relation to CVD prevalence among diverse Hispanic/Latino workers. Methods: Cross-sectional data from 7404 employed individuals, aged 18-74 years, enrolled in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) were analysed. Participants from four US cities provided questionnaire data and underwent clinical examinations, including ECGs. CVD was defined as the presence of at least one of the following: coronary heart disease, atrial fibrillation, heart failure or cerebrovascular disease. Prevalence ratios reflecting the relationship between each occupational exposure and CVD as well as CVD subtypes were calculated using Poisson regression models. Results: Hispanic/Latino workers reported exposures to organic solvents (6.5{\%}), metals (8.5{\%}) and pesticides (4.7{\%}) at their current jobs. Overall, 6.1{\%} of participants had some form of CVD, with coronary heart disease as the most common (4.3{\%}) followed by cerebrovascular disease (1.0{\%}), heart failure (0.8{\%}) and atrial fibrillation (0.7{\%}). For individuals who reported working with pesticides, the prevalence ratios for any CVD were 2.18 (95{\%} CI 1.34 to 3.55), coronary heart disease 2.20 (95{\%} CI 1.31 to 3.71), cerebrovascular disease 1.38 (95{\%} CI 0.62 3.03), heart failure 0.91 (95{\%} CI 0.23 to 3.54) and atrial fibrillation 5.92 (95{\%} CI 1.89 to 18.61) after adjustment for sociodemographic, acculturation, lifestyle and occupational characteristics. Metal exposures were associated with an almost fourfold (3.78, 95{\%} CI 1.24 to 11.46) greater prevalence of atrial fibrillation. Null associations were observed for organic solvent exposures. Conclusions: Our results suggest that working with metals and pesticides could be risk factors for CVD among Hispanic/Latino workers. Further work is needed to evaluate these relationships prospectively.",
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AU - Daviglus, Martha L.

AU - Persky, Victoria W.

AU - Durazo-Arvizu, Ramon A.

AU - Lash, James P.

AU - Elfassy, Tali

AU - Lee, David J

AU - Ramos, Alberto

AU - Tarraf, Wassim

AU - Argos, Maria

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N2 - Objective: Cardiovascular disease (CVD) is a leading cause of mortality and morbidity in the USA. The role of occupational exposures to chemicals in the development of CVD has rarely been studied even though many agents possess cardiotoxic properties. We therefore evaluated associations of self-reported exposures to organic solvents, metals and pesticides in relation to CVD prevalence among diverse Hispanic/Latino workers. Methods: Cross-sectional data from 7404 employed individuals, aged 18-74 years, enrolled in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) were analysed. Participants from four US cities provided questionnaire data and underwent clinical examinations, including ECGs. CVD was defined as the presence of at least one of the following: coronary heart disease, atrial fibrillation, heart failure or cerebrovascular disease. Prevalence ratios reflecting the relationship between each occupational exposure and CVD as well as CVD subtypes were calculated using Poisson regression models. Results: Hispanic/Latino workers reported exposures to organic solvents (6.5%), metals (8.5%) and pesticides (4.7%) at their current jobs. Overall, 6.1% of participants had some form of CVD, with coronary heart disease as the most common (4.3%) followed by cerebrovascular disease (1.0%), heart failure (0.8%) and atrial fibrillation (0.7%). For individuals who reported working with pesticides, the prevalence ratios for any CVD were 2.18 (95% CI 1.34 to 3.55), coronary heart disease 2.20 (95% CI 1.31 to 3.71), cerebrovascular disease 1.38 (95% CI 0.62 3.03), heart failure 0.91 (95% CI 0.23 to 3.54) and atrial fibrillation 5.92 (95% CI 1.89 to 18.61) after adjustment for sociodemographic, acculturation, lifestyle and occupational characteristics. Metal exposures were associated with an almost fourfold (3.78, 95% CI 1.24 to 11.46) greater prevalence of atrial fibrillation. Null associations were observed for organic solvent exposures. Conclusions: Our results suggest that working with metals and pesticides could be risk factors for CVD among Hispanic/Latino workers. Further work is needed to evaluate these relationships prospectively.

AB - Objective: Cardiovascular disease (CVD) is a leading cause of mortality and morbidity in the USA. The role of occupational exposures to chemicals in the development of CVD has rarely been studied even though many agents possess cardiotoxic properties. We therefore evaluated associations of self-reported exposures to organic solvents, metals and pesticides in relation to CVD prevalence among diverse Hispanic/Latino workers. Methods: Cross-sectional data from 7404 employed individuals, aged 18-74 years, enrolled in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) were analysed. Participants from four US cities provided questionnaire data and underwent clinical examinations, including ECGs. CVD was defined as the presence of at least one of the following: coronary heart disease, atrial fibrillation, heart failure or cerebrovascular disease. Prevalence ratios reflecting the relationship between each occupational exposure and CVD as well as CVD subtypes were calculated using Poisson regression models. Results: Hispanic/Latino workers reported exposures to organic solvents (6.5%), metals (8.5%) and pesticides (4.7%) at their current jobs. Overall, 6.1% of participants had some form of CVD, with coronary heart disease as the most common (4.3%) followed by cerebrovascular disease (1.0%), heart failure (0.8%) and atrial fibrillation (0.7%). For individuals who reported working with pesticides, the prevalence ratios for any CVD were 2.18 (95% CI 1.34 to 3.55), coronary heart disease 2.20 (95% CI 1.31 to 3.71), cerebrovascular disease 1.38 (95% CI 0.62 3.03), heart failure 0.91 (95% CI 0.23 to 3.54) and atrial fibrillation 5.92 (95% CI 1.89 to 18.61) after adjustment for sociodemographic, acculturation, lifestyle and occupational characteristics. Metal exposures were associated with an almost fourfold (3.78, 95% CI 1.24 to 11.46) greater prevalence of atrial fibrillation. Null associations were observed for organic solvent exposures. Conclusions: Our results suggest that working with metals and pesticides could be risk factors for CVD among Hispanic/Latino workers. Further work is needed to evaluate these relationships prospectively.

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