Association of neutrophil to lymphocyte ratio and pulmonary hypertension in sarcoidosis patients

Mehdi Mirsaeidi, Esmaeil Mortaz, Hesham R. Omar, Enrico M. Camporesi, Nadera Sweiss

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: The neutrophil-to-lymphocyte ratio (NLR) has emerged as a new marker of inflammation associated with the severity of several respiratory and cardiac diseases. Materials and Methods: We investigated whether the degree of systemic inflammation in sarcoidosis patients as measured by the NLR is associated with pulmonary hypertension (PH). Results: A NLR > 3.5 occurred with a significantly higher frequency in sarcoidosis patients with PH (50% vs. 24%, P=0.016) yielding a sensitivity of 50%, specificity of 78%, positive predictive value (PPV) of 41.9% and negative predictive value (NPV) of 81.4% and remained independently associated with PH in multivariate analysis (OR: 3.254, 95% CI: 1.094-9.678, P=0.034). Conclusion: We conclude that level of inflammation in sarcoidosis patients may be associated with the development of PH. Owing to the relatively good specificity and NPV, NLR may be a good negative test, which is a simple, inexpensive and widely available in office-based setting to predict the risk of PH in sarcoidosis patients.

Original languageEnglish (US)
Pages (from-to)44-47
Number of pages4
JournalTanaffos
Volume15
Issue number1
StatePublished - 2016

Fingerprint

Sarcoidosis
Pulmonary Hypertension
Neutrophils
Lymphocytes
Inflammation
Heart Diseases
Multivariate Analysis
Sensitivity and Specificity

Keywords

  • Blood
  • Diagnosis
  • Marker
  • Pulmonary hypertension
  • Sarcoidosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Mirsaeidi, M., Mortaz, E., Omar, H. R., Camporesi, E. M., & Sweiss, N. (2016). Association of neutrophil to lymphocyte ratio and pulmonary hypertension in sarcoidosis patients. Tanaffos, 15(1), 44-47.

Association of neutrophil to lymphocyte ratio and pulmonary hypertension in sarcoidosis patients. / Mirsaeidi, Mehdi; Mortaz, Esmaeil; Omar, Hesham R.; Camporesi, Enrico M.; Sweiss, Nadera.

In: Tanaffos, Vol. 15, No. 1, 2016, p. 44-47.

Research output: Contribution to journalArticle

Mirsaeidi, M, Mortaz, E, Omar, HR, Camporesi, EM & Sweiss, N 2016, 'Association of neutrophil to lymphocyte ratio and pulmonary hypertension in sarcoidosis patients', Tanaffos, vol. 15, no. 1, pp. 44-47.
Mirsaeidi, Mehdi ; Mortaz, Esmaeil ; Omar, Hesham R. ; Camporesi, Enrico M. ; Sweiss, Nadera. / Association of neutrophil to lymphocyte ratio and pulmonary hypertension in sarcoidosis patients. In: Tanaffos. 2016 ; Vol. 15, No. 1. pp. 44-47.
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