Association of neurogranin gene expression with Alzheimer's disease pathology in the perirhinal cortex

Xiaoyan Sun, Qian Wang, Kaj Blennow, Henrik Zetterberg, Micheline McCarthy, David A. Loewenstein, Regina Vontell, Zhenyu Yue, Bin Zhang

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Synaptic damage is a key pathology of Alzheimer's disease (AD). The mechanism underlying synaptic vulnerability in AD remains elusive. Methods: Using a large-scale transcriptomic dataset, we analyzed the neurogranin-centered integrative gene network and assessed the correlation of neurogranin (NRGN) gene expression with AD pathology in post mortem brains. We studied the association of NRGN expression with Clinical Dementia Rating (CDR) and neuropathological diagnosis of AD. Results: We find that the genes positively correlated with NRGN expression in AD are involved in synaptic transmission and cation channel pathways. NRGN expression is correlated with amyloid and tau pathology in the perirhinal cortex of post mortem brains. NRGN expression is associated with the diagnosis of AD and correlated with CDR. Discussion: Transcriptional regulation of the gene encoding for synaptic protein is involved in selective synaptic damage in AD. Identifying the genes associated with synaptic damage pathways in AD may provide targets for intervention.

Original languageEnglish (US)
Article numbere12162
JournalAlzheimer's and Dementia: Translational Research and Clinical Interventions
Volume7
Issue number1
DOIs
StatePublished - 2021
Externally publishedYes

Keywords

  • Alzheimer's disease
  • amyloid
  • integrative gene network
  • neurogranin
  • perirhinal cortex
  • synapse
  • tau

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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