Association of metabolic syndrome and change in Unified Parkinson's Disease Rating Scale scores

Maureen Leehey, Sheng Luo, Saloni Sharma, Anne Marie A. Wills, Jacquelyn L. Bainbridge, Pei Shieen Wong, David K. Simon, Jay Schneider, Yunxi Zhang, Adriana Pérez, Rohit Dhall, Chadwick W. Christine, Carlos Singer, Franca Cambi, James T. Boyd

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Objective: To explore the association between metabolic syndrome and the Unified Parkinson's Disease Rating Scale (UPDRS) scores and, secondarily, the Symbol Digit Modalities Test (SDMT). Methods: This is a secondary analysis of data from 1,022 of 1,741 participants of the National Institute of Neurological Disorders and Stroke Exploratory Clinical Trials in Parkinson Disease Long-Term Study 1, a randomized, placebo-controlled trial of creatine. Participants were categorized as having or not having metabolic syndrome on the basis of modified criteria from the National Cholesterol Education Program Adult Treatment Panel III. Those who had the same metabolic syndrome status at consecutive annual visits were included. The change in UPDRS and SDMT scores from randomization to 3 years was compared in participants with and without metabolic syndrome. Results: Participants with metabolic syndrome (n 5 396) compared to those without (n 5 626) were older (mean [SD] 63.9 [8.1] vs 59.9 [9.4] years; p<0.0001), were more likely to be male (75.3% vs 57.0%; p<0.0001), and had a higher mean uric acid level (men 5.7 [1.3] vs 5.3 [1.1] mg/dL, women 4.9 [1.3] vs 3.9 [0.9] mg/dL, p<0.0001). Participants with metabolic syndrome experienced an additional 0.6- (0.2) unit annual increase in total UPDRS (p 5 0.02) and 0.5- (0.2) unit increase in motor UPDRS (p 5 0.01) scores compared with participants without metabolic syndrome. There was no difference in the change in SDMT scores. Conclusions: Persons with Parkinson disease meeting modified criteria for metabolic syndrome experienced a greater increase in total UPDRS scores over time, mainly as a result of increases in motor scores, compared to those who did not. Further studies are needed to confirm this finding.

Original languageEnglish (US)
Pages (from-to)1789-1794
Number of pages6
Issue number17
StatePublished - Oct 24 2017

ASJC Scopus subject areas

  • Clinical Neurology


Dive into the research topics of 'Association of metabolic syndrome and change in Unified Parkinson's Disease Rating Scale scores'. Together they form a unique fingerprint.

Cite this