Association of interleukin-10 with rejection-sparing effect in septic kidney transplant recipients

George W Burke, Gaetano Ciancio, Robert Cirocco, Michael Markou, Donald Coker, David Roth, Jose Nery, Violet Esquenazi, Joshua Miller

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Certain cytokines, particularly γ-interferon (IFN) and interleukin (IL)- 2 associated with T(H)1 cell function, have been shown to play a role in allograft rejection. One paradigm for long-term allograft acceptance involves T(H)2 cytokine predominance (IL-4 and IL-10). We describe two renal allograft recipients for whom immunosuppression was discontinued due to serious sepsis and who maintained stable renal function over 2-6 months without immunosuppression. During this time, there were higher levels of both IFN-γ and IL-10 in the peripheral blood than in stable control kidney transplant recipients on immunosuppression. In one of the patients, levels of IL-10 fell, while those of IFN-γ remained persistently elevated. This was associated with biopsy-proven rejection. Although peripheral blood cytokine levels may not reflect intragraft events, these data are consistent with an allograft protective role for IL-10 offsetting that of IFN-γ in bath patients off immunosuppression.

Original languageEnglish
Pages (from-to)1114-1116
Number of pages3
JournalTransplantation
Volume61
Issue number7
DOIs
StatePublished - Apr 15 1996

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Interleukin-10
Immunosuppression
Interferons
Allografts
Kidney
Cytokines
Baths
Interleukin-4
Interleukin-2
Sepsis
Biopsy
Transplant Recipients

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Association of interleukin-10 with rejection-sparing effect in septic kidney transplant recipients. / Burke, George W; Ciancio, Gaetano; Cirocco, Robert; Markou, Michael; Coker, Donald; Roth, David; Nery, Jose; Esquenazi, Violet; Miller, Joshua.

In: Transplantation, Vol. 61, No. 7, 15.04.1996, p. 1114-1116.

Research output: Contribution to journalArticle

Burke, George W ; Ciancio, Gaetano ; Cirocco, Robert ; Markou, Michael ; Coker, Donald ; Roth, David ; Nery, Jose ; Esquenazi, Violet ; Miller, Joshua. / Association of interleukin-10 with rejection-sparing effect in septic kidney transplant recipients. In: Transplantation. 1996 ; Vol. 61, No. 7. pp. 1114-1116.
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AU - Roth, David

AU - Nery, Jose

AU - Esquenazi, Violet

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