Abstract
Certain cytokines, particularly γ-interferon (IFN) and interleukin (IL)- 2 associated with T(H)1 cell function, have been shown to play a role in allograft rejection. One paradigm for long-term allograft acceptance involves T(H)2 cytokine predominance (IL-4 and IL-10). We describe two renal allograft recipients for whom immunosuppression was discontinued due to serious sepsis and who maintained stable renal function over 2-6 months without immunosuppression. During this time, there were higher levels of both IFN-γ and IL-10 in the peripheral blood than in stable control kidney transplant recipients on immunosuppression. In one of the patients, levels of IL-10 fell, while those of IFN-γ remained persistently elevated. This was associated with biopsy-proven rejection. Although peripheral blood cytokine levels may not reflect intragraft events, these data are consistent with an allograft protective role for IL-10 offsetting that of IFN-γ in bath patients off immunosuppression.
| Original language | English |
|---|---|
| Pages (from-to) | 1114-1116 |
| Number of pages | 3 |
| Journal | Transplantation |
| Volume | 61 |
| Issue number | 7 |
| DOIs | |
| State | Published - Apr 15 1996 |
Fingerprint
ASJC Scopus subject areas
- Transplantation
- Immunology
Cite this
Association of interleukin-10 with rejection-sparing effect in septic kidney transplant recipients. / Burke, George W; Ciancio, Gaetano; Cirocco, Robert; Markou, Michael; Coker, Donald; Roth, David; Nery, Jose; Esquenazi, Violet; Miller, Joshua.
In: Transplantation, Vol. 61, No. 7, 15.04.1996, p. 1114-1116.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association of interleukin-10 with rejection-sparing effect in septic kidney transplant recipients
AU - Burke, George W
AU - Ciancio, Gaetano
AU - Cirocco, Robert
AU - Markou, Michael
AU - Coker, Donald
AU - Roth, David
AU - Nery, Jose
AU - Esquenazi, Violet
AU - Miller, Joshua
PY - 1996/4/15
Y1 - 1996/4/15
N2 - Certain cytokines, particularly γ-interferon (IFN) and interleukin (IL)- 2 associated with T(H)1 cell function, have been shown to play a role in allograft rejection. One paradigm for long-term allograft acceptance involves T(H)2 cytokine predominance (IL-4 and IL-10). We describe two renal allograft recipients for whom immunosuppression was discontinued due to serious sepsis and who maintained stable renal function over 2-6 months without immunosuppression. During this time, there were higher levels of both IFN-γ and IL-10 in the peripheral blood than in stable control kidney transplant recipients on immunosuppression. In one of the patients, levels of IL-10 fell, while those of IFN-γ remained persistently elevated. This was associated with biopsy-proven rejection. Although peripheral blood cytokine levels may not reflect intragraft events, these data are consistent with an allograft protective role for IL-10 offsetting that of IFN-γ in bath patients off immunosuppression.
AB - Certain cytokines, particularly γ-interferon (IFN) and interleukin (IL)- 2 associated with T(H)1 cell function, have been shown to play a role in allograft rejection. One paradigm for long-term allograft acceptance involves T(H)2 cytokine predominance (IL-4 and IL-10). We describe two renal allograft recipients for whom immunosuppression was discontinued due to serious sepsis and who maintained stable renal function over 2-6 months without immunosuppression. During this time, there were higher levels of both IFN-γ and IL-10 in the peripheral blood than in stable control kidney transplant recipients on immunosuppression. In one of the patients, levels of IL-10 fell, while those of IFN-γ remained persistently elevated. This was associated with biopsy-proven rejection. Although peripheral blood cytokine levels may not reflect intragraft events, these data are consistent with an allograft protective role for IL-10 offsetting that of IFN-γ in bath patients off immunosuppression.
UR - http://www.scopus.com/inward/record.url?scp=0029925478&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029925478&partnerID=8YFLogxK
U2 - 10.1097/00007890-199604150-00023
DO - 10.1097/00007890-199604150-00023
M3 - Article
C2 - 8623196
AN - SCOPUS:0029925478
VL - 61
SP - 1114
EP - 1116
JO - Transplantation
JF - Transplantation
SN - 0041-1337
IS - 7
ER -