Association of hypothyroidism with unruptured cerebral aneurysms: A case-control study

Kunakorn Atchaneeyasakul, Anita Tipirneni, Tony Zhang, Priyank Khandelwal, Sudheer Ambekar, Brian Snelling, Sushrut Dharmadhikari, Chuanhui Dong, Luis Guada, Kevin Ramdas, Seemant Chaturvedi, Tatjana Rundek, Dileep R. Yavagal

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


OBJECTIVE: Thyroid disorder has been known to affect vascular function and has been associated with aortic aneurysm formation in some cases; however, the connection has not been well studied. The authors hypothesized that hypothyroidism is associated with the formation of cerebral aneurysms. METHODS: The authors performed a retrospective case-control study of consecutive patients who had undergone cerebral angiography at an academic, tertiary care medical center in the period from April 2004 through April 2014. Patients with unruptured aneurysms were identified from among those who had undergone 3-vessel catheter angiography. Agematched controls without cerebral aneurysms on angiography were also identified from the same database. Patients with previous subarachnoid hemorrhage or intracranial hemorrhage were excluded. History of hypothyroidism and other risk factors were recorded. RESULTS: Two hundred forty-three patients with unruptured cerebral aneurysms were identified and age matched with 243 controls. Mean aneurysm size was 9.6 ± 0.8 mm. Hypothyroidism was present in 40 patients (16.5%) and 9 matched controls (3.7%; adjusted OR 3.2, 95% CI 1.3-7.8, p = 0.01). Subgroup analysis showed that men with hypothyroidism had higher odds of an unruptured cerebral aneurysm diagnosis than the women with hypothyroidism, with an adjusted OR of 12.7 (95% CI 1.3-121.9) versus an OR of 2.5 (95% CI 1.0-6.4) on multivariate analysis. CONCLUSIONS: Hypothyroidism appears to be independently associated with unruptured cerebral aneurysms, with a higher effect seen in men. Given the known pathophysiological associations between hypothyroidism and vascular dysfunction, this finding warrants further exploration.

Original languageEnglish (US)
Pages (from-to)511-514
Number of pages4
JournalJournal of neurosurgery
Issue number2
StatePublished - Feb 2018


  • Cerebral aneurysm
  • Cerebral angiography
  • Hypothyroidism
  • Subarachnoid hemorrhage
  • Vascular disorders

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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