Association of Household Food- and Drink-Sharing Practices with Human Herpesvirus 8 Seroconversion in a Cohort of Zambian Children

Kay L. Crabtree, Janet M. Wojcicki, Veenu Minhas, Chipepo Kankasa, Charles D Mitchell, Charles Wood

Research output: Contribution to journalArticle

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Abstract

Background Human herpesvirus 8 (HHV-8) infection occurs in early childhood and is associated with human immunodeficiency virus type 1 (HIV-1) infection and risk for Kaposi sarcoma, but behaviors associated with HHV-8 transmission are not well described. Methods We enrolled and followed a prospective cohort of 270 children and their household members to investigate risk factors for HHV-8 transmission in Lusaka, Zambia. Results We report an incidence of 30.07 seroconversions per 100 child-years. Independent risk factors for HHV-8 incident infection included having a child who shared utensils with a primary caregiver (hazards ratio [HR], 2.33; 95% confidence interval [CI], 1.49-7.14), having an increasing number of HHV-8-infected household members (HR, 1.27; 95% CI, 1.09-2.79), and having ≥5 siblings/children in the household (HR, 2.24; 95% CI, 1.03-4.88). Playing with >5 children a day was protective against infection (HR, 0.54; 95% CI,.33-0.89), as was increasing child age (HR, 0.96; 95% CI,.93-.99). Conclusions This is the first study to find a temporal association between limited child feeding behaviors and risk for HHV-8 infection. Child food- and drink-sharing behaviors should be included in efforts to minimize HHV-8 transmission, and households with a large number of siblings should receive additional counseling as childhood infections occur in the home context.

Original languageEnglish (US)
Pages (from-to)842-849
Number of pages8
JournalJournal of Infectious Diseases
Volume216
Issue number7
DOIs
StatePublished - Jan 1 2017

Fingerprint

Human Herpesvirus 8
Food
Confidence Intervals
Herpesviridae Infections
Siblings
Infection
Zambia
Kaposi's Sarcoma
Child Behavior
Feeding Behavior
Virus Diseases
Seroconversion
Caregivers
HIV-1
Counseling
Incidence

Keywords

  • human herpesvirus 8
  • Kaposi's sarcoma-associated herpesvirus
  • premastication
  • sub-Saharan Africa

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Association of Household Food- and Drink-Sharing Practices with Human Herpesvirus 8 Seroconversion in a Cohort of Zambian Children. / Crabtree, Kay L.; Wojcicki, Janet M.; Minhas, Veenu; Kankasa, Chipepo; Mitchell, Charles D; Wood, Charles.

In: Journal of Infectious Diseases, Vol. 216, No. 7, 01.01.2017, p. 842-849.

Research output: Contribution to journalArticle

Crabtree, Kay L. ; Wojcicki, Janet M. ; Minhas, Veenu ; Kankasa, Chipepo ; Mitchell, Charles D ; Wood, Charles. / Association of Household Food- and Drink-Sharing Practices with Human Herpesvirus 8 Seroconversion in a Cohort of Zambian Children. In: Journal of Infectious Diseases. 2017 ; Vol. 216, No. 7. pp. 842-849.
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abstract = "Background Human herpesvirus 8 (HHV-8) infection occurs in early childhood and is associated with human immunodeficiency virus type 1 (HIV-1) infection and risk for Kaposi sarcoma, but behaviors associated with HHV-8 transmission are not well described. Methods We enrolled and followed a prospective cohort of 270 children and their household members to investigate risk factors for HHV-8 transmission in Lusaka, Zambia. Results We report an incidence of 30.07 seroconversions per 100 child-years. Independent risk factors for HHV-8 incident infection included having a child who shared utensils with a primary caregiver (hazards ratio [HR], 2.33; 95{\%} confidence interval [CI], 1.49-7.14), having an increasing number of HHV-8-infected household members (HR, 1.27; 95{\%} CI, 1.09-2.79), and having ≥5 siblings/children in the household (HR, 2.24; 95{\%} CI, 1.03-4.88). Playing with >5 children a day was protective against infection (HR, 0.54; 95{\%} CI,.33-0.89), as was increasing child age (HR, 0.96; 95{\%} CI,.93-.99). Conclusions This is the first study to find a temporal association between limited child feeding behaviors and risk for HHV-8 infection. Child food- and drink-sharing behaviors should be included in efforts to minimize HHV-8 transmission, and households with a large number of siblings should receive additional counseling as childhood infections occur in the home context.",
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