Association of High-Density Lipoprotein Cholesterol With Cognitive Function: Findings From the PROspective Study of Pravastatin in the Elderly at Risk

Leslie Grasset, Roelof A.J. Smit, Michelle R. Caunca, Tali Elfassy, Michelle C. Odden, Jeroen van der Grond, Mark A. van Buchem, David J. Stott, Naveed Sattar, Stella Trompet, J. Wouter Jukema, Adina Zeki Al Hazzouri

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Objective: We aimed to examine whether variability in high-density lipoprotein cholesterol (HDL-c) over time was associated with cognitive function. Method: We conducted a post hoc analysis of the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) trial. Our sample included 4,428 participants with at least two repeated HDL-c measures between Months 3 and 24 postbaseline and with cognitive assessments at Month 30. HDL-c variability was defined as the intraindividual standard deviation over each person’s repeated measurements. Results: Higher HDL-c variability was associated with worse performance on the Letter-Digit Coding Test (β [95% confidence interval] [CI] = −4.39 [−7.36, −1.43], p =.004), immediate recall on the 15-Picture Learning Test (β [95% CI] = −0.98 [−1.86, −0.11], p =.027), and delayed recall on the 15-Picture Learning Test (β [95% CI] = −1.90 [−3.14, −0.67], p =.002). The associations did not vary by treatment group. Discussion: Our findings suggest that variability in HDL-c may be associated with poor cognitive function among older adults.

Original languageEnglish (US)
Pages (from-to)1267-1274
Number of pages8
JournalJournal of Aging and Health
Volume32
Issue number9
DOIs
StatePublished - Oct 2020

Keywords

  • cognition
  • homeostasis
  • lipid
  • variability
  • vascular

ASJC Scopus subject areas

  • Health(social science)
  • Sociology and Political Science
  • Life-span and Life-course Studies

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