Association of heterotopic gray matter with seizures: MR imaging

A. S. Smith, M. A. Weinstein, R. M. Quencer, L. R. Muroff, K. J. Stonesifer, F. C. Li, L. Wener, M. A. Soloman, R. P. Cruse, L. H. Rosenberg, J. P. Berke

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


Heterotopic gray matter, which previously had been associated with severe congenital malformations of the brain and developmental delay, was found without these associated conditions. The authors found ten cases of heterotopic gray matter on magnetic resonance (MR) images. The lesions had a signal intensity that was isointense compared with that of gray matter on T1, spin-density, and T2-weighted images. Nine of the ten cases were associated with a seizure disorder. The tenth case, discovered during a workup for metastatic lung disease, was confirmed with pathologic studies. Heterotopic gray matter is the presence of cortical neurons in an abnormal location, which may be periventricular (nodular) or within the white matter (laminar). A knowledge of heterotopic gray matter and its association with seizures may prevent the misinterpretation of findings on MR images.

Original languageEnglish (US)
Pages (from-to)195-198
Number of pages4
Issue number1
StatePublished - Jan 1 1988
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Association of heterotopic gray matter with seizures: MR imaging'. Together they form a unique fingerprint.

Cite this