Association of Escherichia coli O157:H7 with necrotizing enterocolitis in a full-term infant

Yigit S. Guner; Ajay Malhotra; Henri R. Ford; James E. Stein; Lisa K. Kelly

doi:10.1007/s00383-009-2365-3

Association of Escherichia coli O157:H7 with necrotizing enterocolitis in a full-term infant

Yigit S. Guner, Ajay Malhotra, Henri R. Ford, James E. Stein, Lisa K. Kelly

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency of the neonate. NEC is predominantly seen in premature infants; however, in rare instances it can affect full-term infants as well. Although the pathogenesis of NEC remains elusive, it is well established that bacterial colonization is required for development of this disease. In this report, we present a case of a full-term infant, who developed a very aggressive form of NEC and was found to have Escherichia coli (E. coli) O157:H7 both in stool and blood cultures. Unfortunately, despite aggressive surgical and intensive care management, this infant suffered pan-intestinal necrosis and expired. We were not able to establish the route of transmission. To our knowledge, this is the first report of the association of E. coli O157:H7 with NEC.

Original language	English (US)
Pages (from-to)	459-463
Number of pages	5
Journal	Pediatric Surgery International
Volume	25
Issue number	5
DOIs	https://doi.org/10.1007/s00383-009-2365-3
State	Published - May 2009
Externally published	Yes

Keywords

Bacteria
HUS
Mortality
NEC
Neonate

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Surgery

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Cite this

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abstract = "Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency of the neonate. NEC is predominantly seen in premature infants; however, in rare instances it can affect full-term infants as well. Although the pathogenesis of NEC remains elusive, it is well established that bacterial colonization is required for development of this disease. In this report, we present a case of a full-term infant, who developed a very aggressive form of NEC and was found to have Escherichia coli (E. coli) O157:H7 both in stool and blood cultures. Unfortunately, despite aggressive surgical and intensive care management, this infant suffered pan-intestinal necrosis and expired. We were not able to establish the route of transmission. To our knowledge, this is the first report of the association of E. coli O157:H7 with NEC.",

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AU - Ford, Henri R.

AU - Stein, James E.

AU - Kelly, Lisa K.

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