Association of Escherichia coli O157:H7 with necrotizing enterocolitis in a full-term infant

Yigit S. Guner, Ajay Malhotra, Henri Ford, James E. Stein, Lisa K. Kelly

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency of the neonate. NEC is predominantly seen in premature infants; however, in rare instances it can affect full-term infants as well. Although the pathogenesis of NEC remains elusive, it is well established that bacterial colonization is required for development of this disease. In this report, we present a case of a full-term infant, who developed a very aggressive form of NEC and was found to have Escherichia coli (E. coli) O157:H7 both in stool and blood cultures. Unfortunately, despite aggressive surgical and intensive care management, this infant suffered pan-intestinal necrosis and expired. We were not able to establish the route of transmission. To our knowledge, this is the first report of the association of E. coli O157:H7 with NEC.

Original languageEnglish (US)
Pages (from-to)459-463
Number of pages5
JournalPediatric Surgery International
Volume25
Issue number5
DOIs
StatePublished - May 1 2009
Externally publishedYes

Fingerprint

Necrotizing Enterocolitis
Escherichia coli O157
Critical Care
Premature Infants
Emergencies
Necrosis
Newborn Infant

Keywords

  • Bacteria
  • HUS
  • Mortality
  • NEC
  • Neonate

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery

Cite this

Association of Escherichia coli O157:H7 with necrotizing enterocolitis in a full-term infant. / Guner, Yigit S.; Malhotra, Ajay; Ford, Henri; Stein, James E.; Kelly, Lisa K.

In: Pediatric Surgery International, Vol. 25, No. 5, 01.05.2009, p. 459-463.

Research output: Contribution to journalArticle

Guner, Yigit S. ; Malhotra, Ajay ; Ford, Henri ; Stein, James E. ; Kelly, Lisa K. / Association of Escherichia coli O157:H7 with necrotizing enterocolitis in a full-term infant. In: Pediatric Surgery International. 2009 ; Vol. 25, No. 5. pp. 459-463.
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