Abstract
Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency of the neonate. NEC is predominantly seen in premature infants; however, in rare instances it can affect full-term infants as well. Although the pathogenesis of NEC remains elusive, it is well established that bacterial colonization is required for development of this disease. In this report, we present a case of a full-term infant, who developed a very aggressive form of NEC and was found to have Escherichia coli (E. coli) O157:H7 both in stool and blood cultures. Unfortunately, despite aggressive surgical and intensive care management, this infant suffered pan-intestinal necrosis and expired. We were not able to establish the route of transmission. To our knowledge, this is the first report of the association of E. coli O157:H7 with NEC.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 459-463 |
| Number of pages | 5 |
| Journal | Pediatric Surgery International |
| Volume | 25 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1 2009 |
| Externally published | Yes |
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Keywords
- Bacteria
- HUS
- Mortality
- NEC
- Neonate
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Surgery
Cite this
Association of Escherichia coli O157:H7 with necrotizing enterocolitis in a full-term infant. / Guner, Yigit S.; Malhotra, Ajay; Ford, Henri; Stein, James E.; Kelly, Lisa K.
In: Pediatric Surgery International, Vol. 25, No. 5, 01.05.2009, p. 459-463.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association of Escherichia coli O157:H7 with necrotizing enterocolitis in a full-term infant
AU - Guner, Yigit S.
AU - Malhotra, Ajay
AU - Ford, Henri
AU - Stein, James E.
AU - Kelly, Lisa K.
PY - 2009/5/1
Y1 - 2009/5/1
N2 - Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency of the neonate. NEC is predominantly seen in premature infants; however, in rare instances it can affect full-term infants as well. Although the pathogenesis of NEC remains elusive, it is well established that bacterial colonization is required for development of this disease. In this report, we present a case of a full-term infant, who developed a very aggressive form of NEC and was found to have Escherichia coli (E. coli) O157:H7 both in stool and blood cultures. Unfortunately, despite aggressive surgical and intensive care management, this infant suffered pan-intestinal necrosis and expired. We were not able to establish the route of transmission. To our knowledge, this is the first report of the association of E. coli O157:H7 with NEC.
AB - Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency of the neonate. NEC is predominantly seen in premature infants; however, in rare instances it can affect full-term infants as well. Although the pathogenesis of NEC remains elusive, it is well established that bacterial colonization is required for development of this disease. In this report, we present a case of a full-term infant, who developed a very aggressive form of NEC and was found to have Escherichia coli (E. coli) O157:H7 both in stool and blood cultures. Unfortunately, despite aggressive surgical and intensive care management, this infant suffered pan-intestinal necrosis and expired. We were not able to establish the route of transmission. To our knowledge, this is the first report of the association of E. coli O157:H7 with NEC.
KW - Bacteria
KW - HUS
KW - Mortality
KW - NEC
KW - Neonate
UR - http://www.scopus.com/inward/record.url?scp=67349150121&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67349150121&partnerID=8YFLogxK
U2 - 10.1007/s00383-009-2365-3
DO - 10.1007/s00383-009-2365-3
M3 - Article
VL - 25
SP - 459
EP - 463
JO - Pediatric Surgery International
JF - Pediatric Surgery International
SN - 0179-0358
IS - 5
ER -