Association of Dementia and Vascular Risk Scores with Cortical Thickness and Cognition in Low-risk Middle-aged Adults

Drew Gourley, Evan P. Pasha, Sonya S. Kaur, Andreana P. Haley, Hirofumi Tanaka

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Background:Increased risk for the future development of Alzheimer disease begins as early as midlife. Algorithm-based scores, such as the Cardiovascular Risk Factors, Aging and Incidence of Dementia (CAIDE) dementia risk score, and the Framingham general cardiovascular disease (CVD) risk score, have been used to determine future risk for the development of cognitive decline and dementia. We evaluated the association between neuroimaging and cognitive measures with the 2 risk scores in middle-aged, cognitively intact adults (49±6 y).Methods:In a cohort of 132 participants collected in 2014, magnetic resonance imaging was used to determine measures of cortical thickness in a priori regions of interest and a neuropsychological battery to assess memory and executive function.Results:The CAIDE dementia risk score was significantly and inversely associated with the cortical thickness of the parahippocampal (r=-0.266; P=0.002) and superior frontal gyrus (r=-0.261; P=0.002) despite a considerable percentage of individuals (99.3%) at low risk for CVD. There was a significant negative association between CAIDE and memory (r=-0.251; P=0.003). Framingham general CVD score was not associated with brain structure or cognitive function.Conclusions:These results indicate that the CAIDE dementia risk score is associated with cortical thickness and cognitive function at midlife in a low-risk population. These data provide insight into subclinical structural and functional changes occurring during midlife associated with future risk for the development of dementia.

Original languageEnglish (US)
Pages (from-to)313-317
Number of pages5
JournalAlzheimer disease and associated disorders
Issue number4
StatePublished - 2020
Externally publishedYes


  • aging
  • CAIDE dementia score
  • Framingham Risk Score
  • magnetic resonance imaging
  • memory

ASJC Scopus subject areas

  • Clinical Psychology
  • Gerontology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


Dive into the research topics of 'Association of Dementia and Vascular Risk Scores with Cortical Thickness and Cognition in Low-risk Middle-aged Adults'. Together they form a unique fingerprint.

Cite this