Association of body size metrics with left atrial phasic volumes and reservoir function in the elderly

Aylin Tugcu, Cesare Russo, Zhezhen Jin, Shunichi Homma, Koki Nakanishi, Mitchell S.V. Elkind, Tatjana Rundek, Ralph L Sacco, Marco R. Di Tullio

Research output: Contribution to journalArticle

Abstract

Aims General obesity, defined by increased body mass index (BMI), is associated with left atrial (LA) enlargement, a marker of cardiovascular risk in the general population. The association between abdominal adiposity, defined by increased waist circumference (WC) or waist-to-hip ratio (WHR), and LA phasic volumes and reservoir function is not well known. The aim of this study was to evaluate the association between different body size metrics and LA phasic volumes and reservoir function in the elderly. Methods and results Participants from the CABL (Cardiovascular Abnormalities and Brain Lesions) study underwent measurement of BMI, WC, and WHR. The LA maximum (LAV max) and minimum (LAV min) volumes, and LA reservoir function, measured as total emptying volume index (LAEVI), total emptying fraction (LAEF), and expansion index (LAEI), were assessed by real-time 3D echocardiography. The study population included 629 participants (mean age 71 ± 9 years, 61% women). Mean BMI was 27.9 ± 4.6 kg/m 2, WC was 95.0 ± 11.7 cm, WHR was 0.91 ± 0.08. After adjusting for multiple potential confounders (demographics, cardiovascular risk factors, left ventricular mass index, and diastolic function), higher WC was significantly associated with higher LA phasic volumes (LAV max, β = 0.10, P = 0.007 and LAV min, β = 0.12, P = 0.002) and reduced reservoir function (LAEVI, β = 0.15, P = 0.001 and LAEI, β = 0.09, P = 0.027). WHR was significantly associated only with reduced reservoir function (LAEVI, β = 0.11, P = 0.012), whereas BMI was not associated with either LA phasic volumes or reservoir function. Conclusion In the elderly, WC may have more impact on LA phasic volumes and reservoir function, and therefore risk for cardiovascular events, than WHR and BMI.

Original languageEnglish (US)
Pages (from-to)1157-1164
Number of pages8
JournalEuropean Heart Journal Cardiovascular Imaging
Volume19
Issue number10
DOIs
StatePublished - Oct 1 2018

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Waist-Hip Ratio
Body Size
Waist Circumference
Body Mass Index
Left Atrial Function
Cardiovascular Abnormalities
Three-Dimensional Echocardiography
Adiposity
Population
Obesity
Demography
Brain

Keywords

  • abdominal adiposity
  • left atrial volume
  • obesity
  • reservoir function
  • three-dimensional echocardiography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Tugcu, A., Russo, C., Jin, Z., Homma, S., Nakanishi, K., Elkind, M. S. V., ... Di Tullio, M. R. (2018). Association of body size metrics with left atrial phasic volumes and reservoir function in the elderly. European Heart Journal Cardiovascular Imaging, 19(10), 1157-1164. https://doi.org/10.1093/ehjci/jex236

Association of body size metrics with left atrial phasic volumes and reservoir function in the elderly. / Tugcu, Aylin; Russo, Cesare; Jin, Zhezhen; Homma, Shunichi; Nakanishi, Koki; Elkind, Mitchell S.V.; Rundek, Tatjana; Sacco, Ralph L; Di Tullio, Marco R.

In: European Heart Journal Cardiovascular Imaging, Vol. 19, No. 10, 01.10.2018, p. 1157-1164.

Research output: Contribution to journalArticle

Tugcu, Aylin ; Russo, Cesare ; Jin, Zhezhen ; Homma, Shunichi ; Nakanishi, Koki ; Elkind, Mitchell S.V. ; Rundek, Tatjana ; Sacco, Ralph L ; Di Tullio, Marco R. / Association of body size metrics with left atrial phasic volumes and reservoir function in the elderly. In: European Heart Journal Cardiovascular Imaging. 2018 ; Vol. 19, No. 10. pp. 1157-1164.
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abstract = "Aims General obesity, defined by increased body mass index (BMI), is associated with left atrial (LA) enlargement, a marker of cardiovascular risk in the general population. The association between abdominal adiposity, defined by increased waist circumference (WC) or waist-to-hip ratio (WHR), and LA phasic volumes and reservoir function is not well known. The aim of this study was to evaluate the association between different body size metrics and LA phasic volumes and reservoir function in the elderly. Methods and results Participants from the CABL (Cardiovascular Abnormalities and Brain Lesions) study underwent measurement of BMI, WC, and WHR. The LA maximum (LAV max) and minimum (LAV min) volumes, and LA reservoir function, measured as total emptying volume index (LAEVI), total emptying fraction (LAEF), and expansion index (LAEI), were assessed by real-time 3D echocardiography. The study population included 629 participants (mean age 71 ± 9 years, 61{\%} women). Mean BMI was 27.9 ± 4.6 kg/m 2, WC was 95.0 ± 11.7 cm, WHR was 0.91 ± 0.08. After adjusting for multiple potential confounders (demographics, cardiovascular risk factors, left ventricular mass index, and diastolic function), higher WC was significantly associated with higher LA phasic volumes (LAV max, β = 0.10, P = 0.007 and LAV min, β = 0.12, P = 0.002) and reduced reservoir function (LAEVI, β = 0.15, P = 0.001 and LAEI, β = 0.09, P = 0.027). WHR was significantly associated only with reduced reservoir function (LAEVI, β = 0.11, P = 0.012), whereas BMI was not associated with either LA phasic volumes or reservoir function. Conclusion In the elderly, WC may have more impact on LA phasic volumes and reservoir function, and therefore risk for cardiovascular events, than WHR and BMI.",
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T1 - Association of body size metrics with left atrial phasic volumes and reservoir function in the elderly

AU - Tugcu, Aylin

AU - Russo, Cesare

AU - Jin, Zhezhen

AU - Homma, Shunichi

AU - Nakanishi, Koki

AU - Elkind, Mitchell S.V.

AU - Rundek, Tatjana

AU - Sacco, Ralph L

AU - Di Tullio, Marco R.

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Aims General obesity, defined by increased body mass index (BMI), is associated with left atrial (LA) enlargement, a marker of cardiovascular risk in the general population. The association between abdominal adiposity, defined by increased waist circumference (WC) or waist-to-hip ratio (WHR), and LA phasic volumes and reservoir function is not well known. The aim of this study was to evaluate the association between different body size metrics and LA phasic volumes and reservoir function in the elderly. Methods and results Participants from the CABL (Cardiovascular Abnormalities and Brain Lesions) study underwent measurement of BMI, WC, and WHR. The LA maximum (LAV max) and minimum (LAV min) volumes, and LA reservoir function, measured as total emptying volume index (LAEVI), total emptying fraction (LAEF), and expansion index (LAEI), were assessed by real-time 3D echocardiography. The study population included 629 participants (mean age 71 ± 9 years, 61% women). Mean BMI was 27.9 ± 4.6 kg/m 2, WC was 95.0 ± 11.7 cm, WHR was 0.91 ± 0.08. After adjusting for multiple potential confounders (demographics, cardiovascular risk factors, left ventricular mass index, and diastolic function), higher WC was significantly associated with higher LA phasic volumes (LAV max, β = 0.10, P = 0.007 and LAV min, β = 0.12, P = 0.002) and reduced reservoir function (LAEVI, β = 0.15, P = 0.001 and LAEI, β = 0.09, P = 0.027). WHR was significantly associated only with reduced reservoir function (LAEVI, β = 0.11, P = 0.012), whereas BMI was not associated with either LA phasic volumes or reservoir function. Conclusion In the elderly, WC may have more impact on LA phasic volumes and reservoir function, and therefore risk for cardiovascular events, than WHR and BMI.

AB - Aims General obesity, defined by increased body mass index (BMI), is associated with left atrial (LA) enlargement, a marker of cardiovascular risk in the general population. The association between abdominal adiposity, defined by increased waist circumference (WC) or waist-to-hip ratio (WHR), and LA phasic volumes and reservoir function is not well known. The aim of this study was to evaluate the association between different body size metrics and LA phasic volumes and reservoir function in the elderly. Methods and results Participants from the CABL (Cardiovascular Abnormalities and Brain Lesions) study underwent measurement of BMI, WC, and WHR. The LA maximum (LAV max) and minimum (LAV min) volumes, and LA reservoir function, measured as total emptying volume index (LAEVI), total emptying fraction (LAEF), and expansion index (LAEI), were assessed by real-time 3D echocardiography. The study population included 629 participants (mean age 71 ± 9 years, 61% women). Mean BMI was 27.9 ± 4.6 kg/m 2, WC was 95.0 ± 11.7 cm, WHR was 0.91 ± 0.08. After adjusting for multiple potential confounders (demographics, cardiovascular risk factors, left ventricular mass index, and diastolic function), higher WC was significantly associated with higher LA phasic volumes (LAV max, β = 0.10, P = 0.007 and LAV min, β = 0.12, P = 0.002) and reduced reservoir function (LAEVI, β = 0.15, P = 0.001 and LAEI, β = 0.09, P = 0.027). WHR was significantly associated only with reduced reservoir function (LAEVI, β = 0.11, P = 0.012), whereas BMI was not associated with either LA phasic volumes or reservoir function. Conclusion In the elderly, WC may have more impact on LA phasic volumes and reservoir function, and therefore risk for cardiovascular events, than WHR and BMI.

KW - abdominal adiposity

KW - left atrial volume

KW - obesity

KW - reservoir function

KW - three-dimensional echocardiography

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