TY - JOUR
T1 - Association of aging and obesity with decreased 17-hydroxyprogesterone, a serum biomarker of intratesticular testosterone
AU - Lima, Thiago Fernandes Negris
AU - Frech, Fabio Stefano
AU - Blachman-Braun, Ruben
AU - Rakitina, Evgeniya
AU - Patel, Premal
AU - Ramasamy, Ranjith
N1 - Publisher Copyright:
© 2020, The Author(s), under exclusive licence to Springer Nature Limited.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020
Y1 - 2020
N2 - Obesity’s negative association with serum testosterone can be explained by either decreasing luteinizing hormone (LH) production from the pituitary gland and/or directly impacting intratesticular testosterone production. We hypothesize that obesity will negatively impact intratesticular testosterone levels when compared to those of non-obese men. We performed a cross-sectional analysis of men with symptoms of testosterone deficiency and male infertility between July 2018 and April 2020 to evaluate the association between body mass index (BMI) and age with intratesticular testosterone (using serum 17-hydroxyprogesterone (17-OHP) as a biomarker), and between BMI with LH. Univariable and multiple linear regression analysis were performed using confounding variables to predict 17-OHP and testosterone. A total of 340 men were selected. Median age was 38 [33–44] years, BMI 27.8 [25.4–31.1] kg/m2, serum testosterone 363 [256.3–469.6] ng/dl, 17-OHP 60.5 [39.3–85.8] ng/dl, and LH 4.2 [2.8–5.7] mIU/ml. Older and obese men had lower testosterone compared to younger and non-obese men. Interestingly, increasing age and higher BMI were associated with lower 17-OHP (p < 0.001). Contrarily, age and BMI were not associated with LH levels (p = 0.478). In conclusion, obesity and aging negatively affected 17-OHP independent of LH, suggesting a possible direct effect on testicular function, rather than a secondary effect from a decline in pituitary signaling.
AB - Obesity’s negative association with serum testosterone can be explained by either decreasing luteinizing hormone (LH) production from the pituitary gland and/or directly impacting intratesticular testosterone production. We hypothesize that obesity will negatively impact intratesticular testosterone levels when compared to those of non-obese men. We performed a cross-sectional analysis of men with symptoms of testosterone deficiency and male infertility between July 2018 and April 2020 to evaluate the association between body mass index (BMI) and age with intratesticular testosterone (using serum 17-hydroxyprogesterone (17-OHP) as a biomarker), and between BMI with LH. Univariable and multiple linear regression analysis were performed using confounding variables to predict 17-OHP and testosterone. A total of 340 men were selected. Median age was 38 [33–44] years, BMI 27.8 [25.4–31.1] kg/m2, serum testosterone 363 [256.3–469.6] ng/dl, 17-OHP 60.5 [39.3–85.8] ng/dl, and LH 4.2 [2.8–5.7] mIU/ml. Older and obese men had lower testosterone compared to younger and non-obese men. Interestingly, increasing age and higher BMI were associated with lower 17-OHP (p < 0.001). Contrarily, age and BMI were not associated with LH levels (p = 0.478). In conclusion, obesity and aging negatively affected 17-OHP independent of LH, suggesting a possible direct effect on testicular function, rather than a secondary effect from a decline in pituitary signaling.
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U2 - 10.1038/s41443-020-00358-8
DO - 10.1038/s41443-020-00358-8
M3 - Article
AN - SCOPUS:85091860211
JO - International Journal of Impotence Research
JF - International Journal of Impotence Research
SN - 0955-9930
ER -