Abstract
Purpose: To evaluate the relationships among age-related macular degeneration (AMD), mortality, and biomarkers of systemic inflammation in patients with acquired immunodeficiency syndrome (AIDS). Design: Case-control study. Methods: In participants with intermediate-stage AMD at enrollment in the Longitudinal Study of the Ocular Complications of AIDS (LSOCA) and 2:1 controls matched for age and sex, cryopreserved baseline plasma specimens were assayed for biomarkers of inflammation, including high-sensitivity C-reactive protein (CRP), interleukin (IL)-6, interferon-γ inducible protein (IP)-10, soluble CD14 (sCD14), soluble CD163 (sCD163), kynurenine/tryptophan (KT) ratio, and intestinal fatty acid binding protein (I-FABP). Main outcome measure was mortality. Results: The study included 189 patients with AMD and 385 controls. In the unadjusted analysis, AMD was associated with mortality (hazard ratio [HR] 1.48; 95% confidence interval [CI] 1.02, 2.15; P =.04). In an adjusted analysis, CRP (HR 1.36; 95% CI 1.08, 1.71; P =.009), IL-6 (HR 1.45; 95% CI 1.11, 1.90; P =.006), and IP-10 (HR 1.41; 95% CI 1.08, 1.84; P =.01) were associated with mortality. In a Cox regression analysis adjusted for human immunodeficiency virus load, blood CD4+ T cell level, CRP, IL-6, and IP-10, the association of AMD with mortality was attenuated (HR 1.08; 95% CI 0.73, 1.59; P =.70), primarily by the addition of the inflammatory biomarkers. Conclusions: These data suggest that the increased mortality observed in patients with AIDS with AMD is, at least in part, a result of systemic inflammation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 230-237 |
| Number of pages | 8 |
| Journal | American Journal of Ophthalmology |
| Volume | 199 |
| DOIs | |
| State | Published - Mar 1 2019 |
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ASJC Scopus subject areas
- Ophthalmology
Cite this
Association of Age-related Macular Degeneration With Mortality in Patients With Acquired Immunodeficiency Syndrome; Role of Systemic Inflammation. / Jabs, Douglas A.; Van Natta, Mark L.; Trang, Garrett; Jones, Norman G.; Milush, Jeffrey M.; Cheu, Ryan; Klatt, Nichole; Danis, Ronald P.; Hunt, Peter W.
In: American Journal of Ophthalmology, Vol. 199, 01.03.2019, p. 230-237.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association of Age-related Macular Degeneration With Mortality in Patients With Acquired Immunodeficiency Syndrome; Role of Systemic Inflammation
AU - Jabs, Douglas A.
AU - Van Natta, Mark L.
AU - Trang, Garrett
AU - Jones, Norman G.
AU - Milush, Jeffrey M.
AU - Cheu, Ryan
AU - Klatt, Nichole
AU - Danis, Ronald P.
AU - Hunt, Peter W.
PY - 2019/3/1
Y1 - 2019/3/1
N2 - Purpose: To evaluate the relationships among age-related macular degeneration (AMD), mortality, and biomarkers of systemic inflammation in patients with acquired immunodeficiency syndrome (AIDS). Design: Case-control study. Methods: In participants with intermediate-stage AMD at enrollment in the Longitudinal Study of the Ocular Complications of AIDS (LSOCA) and 2:1 controls matched for age and sex, cryopreserved baseline plasma specimens were assayed for biomarkers of inflammation, including high-sensitivity C-reactive protein (CRP), interleukin (IL)-6, interferon-γ inducible protein (IP)-10, soluble CD14 (sCD14), soluble CD163 (sCD163), kynurenine/tryptophan (KT) ratio, and intestinal fatty acid binding protein (I-FABP). Main outcome measure was mortality. Results: The study included 189 patients with AMD and 385 controls. In the unadjusted analysis, AMD was associated with mortality (hazard ratio [HR] 1.48; 95% confidence interval [CI] 1.02, 2.15; P =.04). In an adjusted analysis, CRP (HR 1.36; 95% CI 1.08, 1.71; P =.009), IL-6 (HR 1.45; 95% CI 1.11, 1.90; P =.006), and IP-10 (HR 1.41; 95% CI 1.08, 1.84; P =.01) were associated with mortality. In a Cox regression analysis adjusted for human immunodeficiency virus load, blood CD4+ T cell level, CRP, IL-6, and IP-10, the association of AMD with mortality was attenuated (HR 1.08; 95% CI 0.73, 1.59; P =.70), primarily by the addition of the inflammatory biomarkers. Conclusions: These data suggest that the increased mortality observed in patients with AIDS with AMD is, at least in part, a result of systemic inflammation.
AB - Purpose: To evaluate the relationships among age-related macular degeneration (AMD), mortality, and biomarkers of systemic inflammation in patients with acquired immunodeficiency syndrome (AIDS). Design: Case-control study. Methods: In participants with intermediate-stage AMD at enrollment in the Longitudinal Study of the Ocular Complications of AIDS (LSOCA) and 2:1 controls matched for age and sex, cryopreserved baseline plasma specimens were assayed for biomarkers of inflammation, including high-sensitivity C-reactive protein (CRP), interleukin (IL)-6, interferon-γ inducible protein (IP)-10, soluble CD14 (sCD14), soluble CD163 (sCD163), kynurenine/tryptophan (KT) ratio, and intestinal fatty acid binding protein (I-FABP). Main outcome measure was mortality. Results: The study included 189 patients with AMD and 385 controls. In the unadjusted analysis, AMD was associated with mortality (hazard ratio [HR] 1.48; 95% confidence interval [CI] 1.02, 2.15; P =.04). In an adjusted analysis, CRP (HR 1.36; 95% CI 1.08, 1.71; P =.009), IL-6 (HR 1.45; 95% CI 1.11, 1.90; P =.006), and IP-10 (HR 1.41; 95% CI 1.08, 1.84; P =.01) were associated with mortality. In a Cox regression analysis adjusted for human immunodeficiency virus load, blood CD4+ T cell level, CRP, IL-6, and IP-10, the association of AMD with mortality was attenuated (HR 1.08; 95% CI 0.73, 1.59; P =.70), primarily by the addition of the inflammatory biomarkers. Conclusions: These data suggest that the increased mortality observed in patients with AIDS with AMD is, at least in part, a result of systemic inflammation.
UR - http://www.scopus.com/inward/record.url?scp=85059813993&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85059813993&partnerID=8YFLogxK
U2 - 10.1016/j.ajo.2018.12.002
DO - 10.1016/j.ajo.2018.12.002
M3 - Article
C2 - 30552890
AN - SCOPUS:85059813993
VL - 199
SP - 230
EP - 237
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
SN - 0002-9394
ER -