Association of a functional μ-opioid receptor allele (+118A) with alcohol dependency

Terrence Town, Laila Abdullah, Fiona Crawford, John Schinka, Patricia Isbell Ordorica, Elie Francis, Patrick Hughes, Ranjan Duara, Michael Mullan

Research output: Contribution to journalArticle

98 Scopus citations

Abstract

Genetic association studies have implicated the TaqI A1 allele of the human dopamine D2 receptor gene (DRD2) as a risk-determining factor for alcohol dependency. However, as alcoholism is a disease of polygenic inheritance, the percentage of overall disease variance explained by the TaqI A1 allele is small. In searching for other genetic loci that may, either alone or in combination with DRD2, enhance prediction of alcoholism, we have found a novel association between a functional coding variant (+118A) within the human μ-opioid receptor gene and alcohol dependency. However, no association was detected between the DRD2 TaqI A1 allele and alcoholism in our sample nor did we find synergy between +118A and TaqI A1 alleles on prediction of risk for the disease. These results suggest that, at the molecular level, the endogenous μ-opioid receptor system is a contributing factor to the etiology of alcoholism.

Original languageEnglish (US)
Pages (from-to)458-461
Number of pages4
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume88
Issue number5
DOIs
StatePublished - Oct 15 1999

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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