TY - JOUR
T1 - Association between the mediterranean diet and metabolic syndrome with serum levels of mirna in morbid obesity
AU - Fontalba-Romero, María I.
AU - López-Enriquez, Soledad
AU - Lago-Sampedro, Ana
AU - Garcia-Escobar, Eva
AU - Pastori, Ricardo L.
AU - Domínguez-Bendala, Juan
AU - Alvarez-Cubela, Silvia
AU - Valdés, Sergio
AU - Rojo-Martinez, Gemma
AU - García-Fuentes, Eduardo
AU - Labajos-Manzanares, María T.
AU - García-Serrano, Sara
N1 - Funding Information:
Funding: This work was supported in part by a grant from the Instituto de Salud Carlos III (PI18/01165) (Spain) and the Consejería de Salud de la Junta de Andalucía (PI-0337-2016) (Spain). This study has been co-funded by FEDER funds (“A way to make Europe”) (“Andalucía se mueve con Europa”).
Funding Information:
This work was supported in part by a grant from the Instituto de Salud Carlos III (PI18/01165) (Spain) and the Consejer?a de Salud de la Junta de Andaluc?a (PI-0337-2016) (Spain). This study has been co-funded by FEDER funds (?A way to make Europe?) (?Andaluc?a se mueve con Europa?).
Funding Information:
Acknowledgments: CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) is an ISCIII project (Spain). E.G.F. and G.R.M. are supported by the Nicolas Monardes program from the Consejería de Salud de Andalucía (Spain) (C-0031-2016 and C-0060-2012, respectively). We thank Gómez-Zumaquero, JM, coordinator of the Genomic ECAI, Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain, for his assistance in molecular biology techniques.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/2
Y1 - 2021/2
N2 - Background: The Mediterranean diet (MD) could be involved in the regulation of different miRNAs related to metabolic syndrome (MS). Methods: We analyzed the serum level of mir-let7a-5p, mir-21, mir-590, mir-107 and mir-192 in patients with morbid obesity and its association with the MD and MS. Results: There is an association between the adherence to MD and higher serum levels of mir-590. Mir-590 was lower in those patients who consumed >2 commercial pastries/week. Mir-let7a was lower in those who consumed ≥1 sweetened drinks, in those who consumed ≥3 pieces of fruit/day and in those who consumed less red than white meat. A lower mir-590 and mir-let7a, and a higher mir-192 level, were found in patients who met the high-density lipoprotein cholesterol (HDL) criterion of MS. A higher mir-192 was found in those patients who met the triglyceride criterion of MS and in those with type 2 diabetes (T2DM). Conclusions: There is an association between specific serum levels of miRNAs and the amount and kind of food intake related to MD. Mir-590 was positively associated with a healthy metabolic profile and type of diet, while mir-192 was positively associated with a worse metabolic profile. These associations could be suggestive of a possible modulation of these miRNAs by food.
AB - Background: The Mediterranean diet (MD) could be involved in the regulation of different miRNAs related to metabolic syndrome (MS). Methods: We analyzed the serum level of mir-let7a-5p, mir-21, mir-590, mir-107 and mir-192 in patients with morbid obesity and its association with the MD and MS. Results: There is an association between the adherence to MD and higher serum levels of mir-590. Mir-590 was lower in those patients who consumed >2 commercial pastries/week. Mir-let7a was lower in those who consumed ≥1 sweetened drinks, in those who consumed ≥3 pieces of fruit/day and in those who consumed less red than white meat. A lower mir-590 and mir-let7a, and a higher mir-192 level, were found in patients who met the high-density lipoprotein cholesterol (HDL) criterion of MS. A higher mir-192 was found in those patients who met the triglyceride criterion of MS and in those with type 2 diabetes (T2DM). Conclusions: There is an association between specific serum levels of miRNAs and the amount and kind of food intake related to MD. Mir-590 was positively associated with a healthy metabolic profile and type of diet, while mir-192 was positively associated with a worse metabolic profile. These associations could be suggestive of a possible modulation of these miRNAs by food.
KW - Mediterranean diet
KW - Metabolic syndrome
KW - MiRNA
KW - Morbid obesity
KW - Type 2 diabetes mellitus
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U2 - 10.3390/nu13020436
DO - 10.3390/nu13020436
M3 - Article
C2 - 33572759
AN - SCOPUS:85099909180
VL - 13
SP - 1
EP - 12
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 2
M1 - 436
ER -