Association between the mediterranean diet and metabolic syndrome with serum levels of mirna in morbid obesity

María I. Fontalba-Romero, Soledad López-Enriquez, Ana Lago-Sampedro, Eva Garcia-Escobar, Ricardo L. Pastori, Juan Domínguez-Bendala, Silvia Alvarez-Cubela, Sergio Valdés, Gemma Rojo-Martinez, Eduardo García-Fuentes, María T. Labajos-Manzanares, Sara García-Serrano

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Background: The Mediterranean diet (MD) could be involved in the regulation of different miRNAs related to metabolic syndrome (MS). Methods: We analyzed the serum level of mir-let7a-5p, mir-21, mir-590, mir-107 and mir-192 in patients with morbid obesity and its association with the MD and MS. Results: There is an association between the adherence to MD and higher serum levels of mir-590. Mir-590 was lower in those patients who consumed >2 commercial pastries/week. Mir-let7a was lower in those who consumed ≥1 sweetened drinks, in those who consumed ≥3 pieces of fruit/day and in those who consumed less red than white meat. A lower mir-590 and mir-let7a, and a higher mir-192 level, were found in patients who met the high-density lipoprotein cholesterol (HDL) criterion of MS. A higher mir-192 was found in those patients who met the triglyceride criterion of MS and in those with type 2 diabetes (T2DM). Conclusions: There is an association between specific serum levels of miRNAs and the amount and kind of food intake related to MD. Mir-590 was positively associated with a healthy metabolic profile and type of diet, while mir-192 was positively associated with a worse metabolic profile. These associations could be suggestive of a possible modulation of these miRNAs by food.

Original languageEnglish (US)
Article number436
Pages (from-to)1-12
Number of pages12
Issue number2
StatePublished - Feb 2021


  • Mediterranean diet
  • Metabolic syndrome
  • MiRNA
  • Morbid obesity
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics


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