Association between Testosterone Supplementation Therapy and Thrombotic Events in Elderly Men

Ranjith Ramasamy, Jason Scovell, Michael Mederos, Renzhong Ren, Lakshay Jain, Larry Lipshultz

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Objective To determine the prevalence of thrombotic events and all-cause mortality in men older than 65 years with hypogonadism treated with testosterone therapy (TST). Patients and Methods We retrospectively reviewed the charts of 217 hypogonadal men >65 years. We compared men who received TST (n = 153) to hypogonadal men (n = 64) who did not receive TST. We evaluated all-cause mortality, prevalence of myocardial infarction (MI), transient ischemic attack (TIA), cerebrovascular accident (CVA or "stroke"), and deep vein thrombosis/pulmonary embolism (DVT/PE). All events were verified by contacting patients. We excluded men with previous thrombotic events, men previously on androgen deprivation therapy, and men who had used TST before age of 65 years. Results Median age and Charlson Comorbidity Index of men on TST (74y; 5.1) was similar to hypogonadal men not on TST (73y, P =.48; 5.3, P =.36). Median follow-up was 3.8 vs 3.5 years (TST vs no TST). No man on TST died, whereas 5 hypogonadal men who did not receive TST died (P =.007). There were 4 thrombotic events (1 MI, 2 CVA/TIA, and 1 PE) in men who received TST and 1 event (CVA/TIA) among men who did not receive TST (P =.8). All events (1 death, 6-month follow-up) occurred at least after 2 years of follow-up. Conclusion There was increased all-cause mortality in hypogonadal men not treated with testosterone compared to men who received TST. There was no difference in prevalence of MI, TIA/CVA, or PE between patients treated with testosterone and hypogonadal men not treated with testosterone.

Original languageEnglish (US)
Pages (from-to)283-286
Number of pages4
JournalUrology
Volume86
Issue number2
DOIs
StatePublished - Aug 1 2015

ASJC Scopus subject areas

  • Urology

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