Association between steroid hormone receptors and response rate to cytotoxic chemotherapy in metastatic breast cancer

J. C. Allegra, Marc E Lippman, E. B. Thompson, R. Simon, A. Barlock, L. Green, K. K. Huff, H. M. Do, S. C. Aitken, R. Warren

Research output: Contribution to journalArticle

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Abstract

The influence of steroid hormone receptors on response rate to cytotoxic chemotherapy in 70 patients with metastatic breast cancer was determined in a retrospective study. We have previously reported that 34 of 45 patients with tumors containing low or absent estrogen-receptor values had objective responses to chemotherapy while three of 25 patients with positive estrogen-receptor tumors responded. In the present study, 22 of 34 patients with low or absent progesterone-receptor tumors had an objective response to cytotoxic chemotherapy, while none of eight patients with a positive progesterone-receptor tumor responded (P<0.05). Patients having tumors with a negative estrogen receptor and a negative progesterone receptor had a response rate of 88% (21 of 24 patients). There were three patients whose tumors were estrogen-receptor negative but progesterone-receptor positive; none had a response to chemotherapy. Chemotherapy response was not associated with the presence or absence of either androgen or glucocorticoid receptor. We conclude that progesterone-receptor values in addition to estrogen-receptor status may prove to be important correlates of response to cytotoxic chemotherapy in metastatic breast cancer. Androgen- and glucocorticoid-receptor analyses are not helpful in predicting response to chemotherapy.

Original languageEnglish
Pages (from-to)1281-1286
Number of pages6
JournalCancer Treatment Reports
Volume62
Issue number9
StatePublished - Dec 1 1978
Externally publishedYes

Fingerprint

Steroid Receptors
Hormones
Breast Neoplasms
Progesterone Receptors
Drug Therapy
Estrogen Receptors
Neoplasms
Glucocorticoid Receptors
Androgen Receptors
Retrospective Studies

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Allegra, J. C., Lippman, M. E., Thompson, E. B., Simon, R., Barlock, A., Green, L., ... Warren, R. (1978). Association between steroid hormone receptors and response rate to cytotoxic chemotherapy in metastatic breast cancer. Cancer Treatment Reports, 62(9), 1281-1286.

Association between steroid hormone receptors and response rate to cytotoxic chemotherapy in metastatic breast cancer. / Allegra, J. C.; Lippman, Marc E; Thompson, E. B.; Simon, R.; Barlock, A.; Green, L.; Huff, K. K.; Do, H. M.; Aitken, S. C.; Warren, R.

In: Cancer Treatment Reports, Vol. 62, No. 9, 01.12.1978, p. 1281-1286.

Research output: Contribution to journalArticle

Allegra, JC, Lippman, ME, Thompson, EB, Simon, R, Barlock, A, Green, L, Huff, KK, Do, HM, Aitken, SC & Warren, R 1978, 'Association between steroid hormone receptors and response rate to cytotoxic chemotherapy in metastatic breast cancer', Cancer Treatment Reports, vol. 62, no. 9, pp. 1281-1286.
Allegra JC, Lippman ME, Thompson EB, Simon R, Barlock A, Green L et al. Association between steroid hormone receptors and response rate to cytotoxic chemotherapy in metastatic breast cancer. Cancer Treatment Reports. 1978 Dec 1;62(9):1281-1286.
Allegra, J. C. ; Lippman, Marc E ; Thompson, E. B. ; Simon, R. ; Barlock, A. ; Green, L. ; Huff, K. K. ; Do, H. M. ; Aitken, S. C. ; Warren, R. / Association between steroid hormone receptors and response rate to cytotoxic chemotherapy in metastatic breast cancer. In: Cancer Treatment Reports. 1978 ; Vol. 62, No. 9. pp. 1281-1286.
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