Association between Serum Tumor Necrosis Factor Receptor 1 and Trajectories of Functional Status

Mandip S. Dhamoon, Ying Kuen Cheung, Yeseon P. Moon, Clinton B Wright, Joshua Z. Willey, Ralph L Sacco, Mitchell S.V. Elkind

Research output: Contribution to journalArticle

Abstract

We hypothesized that tumor necrosis factor receptor 1 (TNFR1) levels are associated with long-term trajectories of functional status independently of vascular risk factors and the occurrence of stroke and myocardial infarction (MI) during follow-up. In the Northern Manhattan Study, stroke-free persons aged .40 years in northern Manhattan (New York, New York) had annual assessments with the Barthel index (BI) for a median of 13 years (1993-2015). Assessment of baseline demographic factors, risk factors, and laboratory studies included measurement of TNFR1 (n = 1,863). Generalized estimating equations models were used to estimate standardized associations between TNFR1 and 1) baseline functional status and 2) change in function over time, adjusting for demographic factors, vascular risk factors, social variables, cognition, and depression, as well as stroke and MI occurrence during follow-up. The mean age of participants was 70 (standard deviation (SD), 10) years; 66% were women, and 55% were Hispanic. The mean TNFR1 level was 2.57 mg/L. TNFR1 was associated with baseline BI (-0.93 BI points per SD increment in TNFR1; 95% confidence interval:-1.59,-0.26) and change over time (.0.36 BI points per year per SD increment in TNFR1; 95% confidence interval:-0.69,-0.03). In this large population-based study, higher TNFR1 levels were associated with greater baseline disability and disability over time, even with adjustment for baseline covariates and stroke and MI occurrence during follow-up.

Original languageEnglish (US)
Pages (from-to)11-20
Number of pages10
JournalAmerican Journal of Epidemiology
Volume186
Issue number1
DOIs
StatePublished - Jul 1 2017

Fingerprint

Tumor Necrosis Factor Receptors
Serum
Stroke
Myocardial Infarction
Demography
Confidence Intervals
Hispanic Americans
Cognition
Depression
Population

Keywords

  • biomarkers
  • Disability
  • functional status
  • inflammation
  • tumor necrosis factor receptor 1

ASJC Scopus subject areas

  • Epidemiology

Cite this

Dhamoon, M. S., Cheung, Y. K., Moon, Y. P., Wright, C. B., Willey, J. Z., Sacco, R. L., & Elkind, M. S. V. (2017). Association between Serum Tumor Necrosis Factor Receptor 1 and Trajectories of Functional Status. American Journal of Epidemiology, 186(1), 11-20. https://doi.org/10.1093/aje/kwx035

Association between Serum Tumor Necrosis Factor Receptor 1 and Trajectories of Functional Status. / Dhamoon, Mandip S.; Cheung, Ying Kuen; Moon, Yeseon P.; Wright, Clinton B; Willey, Joshua Z.; Sacco, Ralph L; Elkind, Mitchell S.V.

In: American Journal of Epidemiology, Vol. 186, No. 1, 01.07.2017, p. 11-20.

Research output: Contribution to journalArticle

Dhamoon, Mandip S. ; Cheung, Ying Kuen ; Moon, Yeseon P. ; Wright, Clinton B ; Willey, Joshua Z. ; Sacco, Ralph L ; Elkind, Mitchell S.V. / Association between Serum Tumor Necrosis Factor Receptor 1 and Trajectories of Functional Status. In: American Journal of Epidemiology. 2017 ; Vol. 186, No. 1. pp. 11-20.
@article{992eba7bde164b9eab12aeed887d75b5,
title = "Association between Serum Tumor Necrosis Factor Receptor 1 and Trajectories of Functional Status",
abstract = "We hypothesized that tumor necrosis factor receptor 1 (TNFR1) levels are associated with long-term trajectories of functional status independently of vascular risk factors and the occurrence of stroke and myocardial infarction (MI) during follow-up. In the Northern Manhattan Study, stroke-free persons aged .40 years in northern Manhattan (New York, New York) had annual assessments with the Barthel index (BI) for a median of 13 years (1993-2015). Assessment of baseline demographic factors, risk factors, and laboratory studies included measurement of TNFR1 (n = 1,863). Generalized estimating equations models were used to estimate standardized associations between TNFR1 and 1) baseline functional status and 2) change in function over time, adjusting for demographic factors, vascular risk factors, social variables, cognition, and depression, as well as stroke and MI occurrence during follow-up. The mean age of participants was 70 (standard deviation (SD), 10) years; 66{\%} were women, and 55{\%} were Hispanic. The mean TNFR1 level was 2.57 mg/L. TNFR1 was associated with baseline BI (-0.93 BI points per SD increment in TNFR1; 95{\%} confidence interval:-1.59,-0.26) and change over time (.0.36 BI points per year per SD increment in TNFR1; 95{\%} confidence interval:-0.69,-0.03). In this large population-based study, higher TNFR1 levels were associated with greater baseline disability and disability over time, even with adjustment for baseline covariates and stroke and MI occurrence during follow-up.",
keywords = "biomarkers, Disability, functional status, inflammation, tumor necrosis factor receptor 1",
author = "Dhamoon, {Mandip S.} and Cheung, {Ying Kuen} and Moon, {Yeseon P.} and Wright, {Clinton B} and Willey, {Joshua Z.} and Sacco, {Ralph L} and Elkind, {Mitchell S.V.}",
year = "2017",
month = "7",
day = "1",
doi = "10.1093/aje/kwx035",
language = "English (US)",
volume = "186",
pages = "11--20",
journal = "American Journal of Epidemiology",
issn = "0002-9262",
publisher = "Oxford University Press",
number = "1",

}

TY - JOUR

T1 - Association between Serum Tumor Necrosis Factor Receptor 1 and Trajectories of Functional Status

AU - Dhamoon, Mandip S.

AU - Cheung, Ying Kuen

AU - Moon, Yeseon P.

AU - Wright, Clinton B

AU - Willey, Joshua Z.

AU - Sacco, Ralph L

AU - Elkind, Mitchell S.V.

PY - 2017/7/1

Y1 - 2017/7/1

N2 - We hypothesized that tumor necrosis factor receptor 1 (TNFR1) levels are associated with long-term trajectories of functional status independently of vascular risk factors and the occurrence of stroke and myocardial infarction (MI) during follow-up. In the Northern Manhattan Study, stroke-free persons aged .40 years in northern Manhattan (New York, New York) had annual assessments with the Barthel index (BI) for a median of 13 years (1993-2015). Assessment of baseline demographic factors, risk factors, and laboratory studies included measurement of TNFR1 (n = 1,863). Generalized estimating equations models were used to estimate standardized associations between TNFR1 and 1) baseline functional status and 2) change in function over time, adjusting for demographic factors, vascular risk factors, social variables, cognition, and depression, as well as stroke and MI occurrence during follow-up. The mean age of participants was 70 (standard deviation (SD), 10) years; 66% were women, and 55% were Hispanic. The mean TNFR1 level was 2.57 mg/L. TNFR1 was associated with baseline BI (-0.93 BI points per SD increment in TNFR1; 95% confidence interval:-1.59,-0.26) and change over time (.0.36 BI points per year per SD increment in TNFR1; 95% confidence interval:-0.69,-0.03). In this large population-based study, higher TNFR1 levels were associated with greater baseline disability and disability over time, even with adjustment for baseline covariates and stroke and MI occurrence during follow-up.

AB - We hypothesized that tumor necrosis factor receptor 1 (TNFR1) levels are associated with long-term trajectories of functional status independently of vascular risk factors and the occurrence of stroke and myocardial infarction (MI) during follow-up. In the Northern Manhattan Study, stroke-free persons aged .40 years in northern Manhattan (New York, New York) had annual assessments with the Barthel index (BI) for a median of 13 years (1993-2015). Assessment of baseline demographic factors, risk factors, and laboratory studies included measurement of TNFR1 (n = 1,863). Generalized estimating equations models were used to estimate standardized associations between TNFR1 and 1) baseline functional status and 2) change in function over time, adjusting for demographic factors, vascular risk factors, social variables, cognition, and depression, as well as stroke and MI occurrence during follow-up. The mean age of participants was 70 (standard deviation (SD), 10) years; 66% were women, and 55% were Hispanic. The mean TNFR1 level was 2.57 mg/L. TNFR1 was associated with baseline BI (-0.93 BI points per SD increment in TNFR1; 95% confidence interval:-1.59,-0.26) and change over time (.0.36 BI points per year per SD increment in TNFR1; 95% confidence interval:-0.69,-0.03). In this large population-based study, higher TNFR1 levels were associated with greater baseline disability and disability over time, even with adjustment for baseline covariates and stroke and MI occurrence during follow-up.

KW - biomarkers

KW - Disability

KW - functional status

KW - inflammation

KW - tumor necrosis factor receptor 1

UR - http://www.scopus.com/inward/record.url?scp=85024362284&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85024362284&partnerID=8YFLogxK

U2 - 10.1093/aje/kwx035

DO - 10.1093/aje/kwx035

M3 - Article

C2 - 28453789

AN - SCOPUS:85024362284

VL - 186

SP - 11

EP - 20

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

IS - 1

ER -