Association between ruptured membranes tocolytic therapy, and respiratory distress syndrome

Luis B. Curet, A. Vijaya Rao, Richard D. Zachman, John C. Morrison, Gene Burkett, W. Kenneth Poole, C. Bauer, Richard Depp, John Boehm, Richard Zachman, Luis Curet, Charles R. Bauer, Louis Fernandez-Roche, Sheldon Korones, John Morrison, Jack Schneider, Garland Anderson, Henrique Rigatto, Leo Peddle, Frank ManningVijaya Rao, David Fukushima, John O'Conner, Jack Kream

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Two hundred ninety-seven patients from the placebo group of the National Institutes of Health Collaborative Study on Antenatal Steroid Therapy for prevention of respiratory distress syndrome were selected for analysis to investigate a possible association between premature rupture of the membranes, tocolytic therapy, and respiratory distress syndrome. Both premature rupture of the membranes and tocolytic therapy with isoxsuprine were individually associated with a lowered incidence of respiratory distress syndrome. However, when present together, their protective effect was not additive and resulted in a higher incidence of respiratory distress syndrome. It is suggested that the use of tocolytic therapy with -adrenergic agents be restricted to patients with intact membranes.

Original languageEnglish (US)
Pages (from-to)263-268
Number of pages6
JournalAmerican journal of obstetrics and gynecology
Volume148
Issue number3
DOIs
StatePublished - 1984

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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