TY - JOUR
T1 - Association between rs2303861 polymorphism in CD82 gene and nonalcoholic fatty liver disease
T2 - A preliminary case-control study
AU - Habibzadeh, Parham
AU - Honarvar, Behnam
AU - Silawi, Mohammad
AU - Bahramjahan, Shima
AU - Kazemi, Azar
AU - Faghihi, Mohammad Ali
AU - Lankarani, Kamran
N1 - Funding Information:
Funding This study was partly supported by a grant from National Institute for Medical Research Development (NIMAD) of Islamic Republic of Iran to KBL and the NIMAD research grant awarded to MAF. The funding agency had no role in the study design, data collection and analysis, and interpretation of results.
Publisher Copyright:
© 2019 Medicinska Naklada Zagreb. All rights reserved.
PY - 2019
Y1 - 2019
N2 - Aim To investigate the genetic factors involved in the development of non-alcoholic fatty liver disease (NAFLD) and its sequelae in a Middle Eastern population. Methods This genetic case-control association study, conducted in 2018, enrolled 30 patients with NAFLD and 30 control individuals matched for age, sex, and body mass index. After quality control measures, entire exonic regions of 3654 genes associated with human diseases were sequenced. Allelic association test and enrichment analysis of the significant genetic variants were performed. Results The association analysis was conducted on 27 NAFLD patients and 28 controls. When Bonferroni correction was applied, NAFLD was significantly associated with rs2303861, a variant located in the CD82 gene (P= 2.49 × 10−7, adjusted P= 0.0059). When we used Benjamini-Hochberg adjustment for correction, NAFLD was significantly associated with six more variants. Enrichment analysis of the genes corresponding to all the seven variants showed significant enrichment for miR-193b-5p (P= 0.00004, adjusted P= 0.00922). Conclusion A variant on CD82 gene and a miR-193b expression dysregulation may have a role in the development and progression of NAFLD and its sequelae.
AB - Aim To investigate the genetic factors involved in the development of non-alcoholic fatty liver disease (NAFLD) and its sequelae in a Middle Eastern population. Methods This genetic case-control association study, conducted in 2018, enrolled 30 patients with NAFLD and 30 control individuals matched for age, sex, and body mass index. After quality control measures, entire exonic regions of 3654 genes associated with human diseases were sequenced. Allelic association test and enrichment analysis of the significant genetic variants were performed. Results The association analysis was conducted on 27 NAFLD patients and 28 controls. When Bonferroni correction was applied, NAFLD was significantly associated with rs2303861, a variant located in the CD82 gene (P= 2.49 × 10−7, adjusted P= 0.0059). When we used Benjamini-Hochberg adjustment for correction, NAFLD was significantly associated with six more variants. Enrichment analysis of the genes corresponding to all the seven variants showed significant enrichment for miR-193b-5p (P= 0.00004, adjusted P= 0.00922). Conclusion A variant on CD82 gene and a miR-193b expression dysregulation may have a role in the development and progression of NAFLD and its sequelae.
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U2 - 10.3325/cmj.2019.60.361
DO - 10.3325/cmj.2019.60.361
M3 - Article
C2 - 31483122
AN - SCOPUS:85071765141
VL - 60
SP - 361
EP - 368
JO - Croatian Medical Journal
JF - Croatian Medical Journal
SN - 0353-9504
IS - 4
ER -