Abstract
The relationship between a premorbid history of depression and the depressive syndrome in Alzheimer's disease (AD) remains equivocal. In the current study, we compared the prevalence of depression among patients with and without a history of mood disturbance prior to the onset of dementia. The sample comprised 243 AD outpatients evaluated consecutively at a university-affiliated memory disorders center. The results indicated that a positive history of depression was more common among patients with current depression compared to those without current depression (23% vs 11%, Fisher's Exact Test, P = .03). This relationship remained significant after controlling for the effects of age, education, gender, ethnicity, and level of cognitive impairment (odds ratio = 2.6, 95% confidence interval = 1.01-6.61, P = .04). Neither gender nor the interaction of gender and history of depression was shown to confer risk for current depressive symptoms. The present investigation suggests that premorbid depression may alter the risk for mood disturbance in AD.
| Original language | English |
|---|---|
| Pages (from-to) | 72-75 |
| Number of pages | 4 |
| Journal | Journal of Geriatric Psychiatry and Neurology |
| Volume | 12 |
| Issue number | 2 |
| DOIs | |
| State | Published - Sep 8 1999 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Neuropsychology and Physiological Psychology
- Geriatrics and Gerontology
- Neuroscience(all)
Cite this
Association between premorbid history of depression and current depression in Alzheimer's disease. / Harwood, Dylan G.; Barker, Warren W.; Ownby, Raymond L.; Duara, Ranjan.
In: Journal of Geriatric Psychiatry and Neurology, Vol. 12, No. 2, 08.09.1999, p. 72-75.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association between premorbid history of depression and current depression in Alzheimer's disease
AU - Harwood, Dylan G.
AU - Barker, Warren W.
AU - Ownby, Raymond L.
AU - Duara, Ranjan
PY - 1999/9/8
Y1 - 1999/9/8
N2 - The relationship between a premorbid history of depression and the depressive syndrome in Alzheimer's disease (AD) remains equivocal. In the current study, we compared the prevalence of depression among patients with and without a history of mood disturbance prior to the onset of dementia. The sample comprised 243 AD outpatients evaluated consecutively at a university-affiliated memory disorders center. The results indicated that a positive history of depression was more common among patients with current depression compared to those without current depression (23% vs 11%, Fisher's Exact Test, P = .03). This relationship remained significant after controlling for the effects of age, education, gender, ethnicity, and level of cognitive impairment (odds ratio = 2.6, 95% confidence interval = 1.01-6.61, P = .04). Neither gender nor the interaction of gender and history of depression was shown to confer risk for current depressive symptoms. The present investigation suggests that premorbid depression may alter the risk for mood disturbance in AD.
AB - The relationship between a premorbid history of depression and the depressive syndrome in Alzheimer's disease (AD) remains equivocal. In the current study, we compared the prevalence of depression among patients with and without a history of mood disturbance prior to the onset of dementia. The sample comprised 243 AD outpatients evaluated consecutively at a university-affiliated memory disorders center. The results indicated that a positive history of depression was more common among patients with current depression compared to those without current depression (23% vs 11%, Fisher's Exact Test, P = .03). This relationship remained significant after controlling for the effects of age, education, gender, ethnicity, and level of cognitive impairment (odds ratio = 2.6, 95% confidence interval = 1.01-6.61, P = .04). Neither gender nor the interaction of gender and history of depression was shown to confer risk for current depressive symptoms. The present investigation suggests that premorbid depression may alter the risk for mood disturbance in AD.
UR - http://www.scopus.com/inward/record.url?scp=0032824784&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032824784&partnerID=8YFLogxK
U2 - 10.1177/089198879901200206
DO - 10.1177/089198879901200206
M3 - Article
C2 - 10483928
AN - SCOPUS:0032824784
VL - 12
SP - 72
EP - 75
JO - Journal of Geriatric Psychiatry and Neurology
JF - Journal of Geriatric Psychiatry and Neurology
SN - 0891-9887
IS - 2
ER -