Association between premorbid history of depression and current depression in Alzheimer's disease

Dylan G. Harwood, Warren W. Barker, Raymond L. Ownby, Ranjan Duara

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The relationship between a premorbid history of depression and the depressive syndrome in Alzheimer's disease (AD) remains equivocal. In the current study, we compared the prevalence of depression among patients with and without a history of mood disturbance prior to the onset of dementia. The sample comprised 243 AD outpatients evaluated consecutively at a university-affiliated memory disorders center. The results indicated that a positive history of depression was more common among patients with current depression compared to those without current depression (23% vs 11%, Fisher's Exact Test, P = .03). This relationship remained significant after controlling for the effects of age, education, gender, ethnicity, and level of cognitive impairment (odds ratio = 2.6, 95% confidence interval = 1.01-6.61, P = .04). Neither gender nor the interaction of gender and history of depression was shown to confer risk for current depressive symptoms. The present investigation suggests that premorbid depression may alter the risk for mood disturbance in AD.

Original languageEnglish
Pages (from-to)72-75
Number of pages4
JournalJournal of Geriatric Psychiatry and Neurology
Volume12
Issue number2
DOIs
StatePublished - Sep 8 1999
Externally publishedYes

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Alzheimer Disease
Depression
Memory Disorders
Depressive Disorder
Dementia
Outpatients
Odds Ratio
Confidence Intervals
Education

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Geriatrics and Gerontology
  • Neuroscience(all)

Cite this

Association between premorbid history of depression and current depression in Alzheimer's disease. / Harwood, Dylan G.; Barker, Warren W.; Ownby, Raymond L.; Duara, Ranjan.

In: Journal of Geriatric Psychiatry and Neurology, Vol. 12, No. 2, 08.09.1999, p. 72-75.

Research output: Contribution to journalArticle

Harwood, Dylan G. ; Barker, Warren W. ; Ownby, Raymond L. ; Duara, Ranjan. / Association between premorbid history of depression and current depression in Alzheimer's disease. In: Journal of Geriatric Psychiatry and Neurology. 1999 ; Vol. 12, No. 2. pp. 72-75.
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