Abstract
The incidence of patients with multiple primary tumors has been increasing in recent years. The association between non-Hodgkin lymphomas (NHL) and renal cell carcinoma (RCC) is unclear. The presentation of 10 patients with co-existent NHL and RCC at our institution in the past 3 years led us to explore whether this was a chance association or a statistically significant phenomenon. We used the US Surveillance, Epidemiology and End Results (SEER) program (www.seer.cancer.gov) from 1973 to 2006 to identify a total of 892 445 537 subjects aged 1884, with known values for race and gender at risk for NHL and RCC. Among these, 181 009 were diagnosed with NHL, 118 122 were diagnosed with RCC and 1039 had both NHL and RCC. This was significantly higher than the expected number of 24 with co-existent NHL and RCC (p < 0.0001). The observed number (O) of RCC after NHL was significantly higher than the expected number (E) (O/E: 1.51; 95% confidence interval [CI] 1.361.66), with the O/E ratio remaining elevated across the various follow-up time intervals. The observed number of NHL after RCC was not significantly different from the expected number (O/E: 1.09; 95% CI 0.981.22). In univariate analyses, race and gender were significantly associated with an increased cumulative incidence of RCC after NHL. Multivariate analysis with age, race and gender revealed that white males had a higher cumulative incidence of RCC after NHL. These findings suggest that patients with NHL are at increased risk for RCC.
| Original language | English |
|---|---|
| Pages (from-to) | 2254-2261 |
| Number of pages | 8 |
| Journal | Leukemia and Lymphoma |
| Volume | 52 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 1 2011 |
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Keywords
- Non-Hodgkin lymphoma
- Renal cell carcinoma
- SEER
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research
Cite this
Association between non-Hodgkin lymphoma and renal cell carcinoma. / Lossos, Chen; Ferrell, Annapoorna; Duncan, Robert; Lossos, Izidore.
In: Leukemia and Lymphoma, Vol. 52, No. 12, 01.12.2011, p. 2254-2261.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association between non-Hodgkin lymphoma and renal cell carcinoma
AU - Lossos, Chen
AU - Ferrell, Annapoorna
AU - Duncan, Robert
AU - Lossos, Izidore
PY - 2011/12/1
Y1 - 2011/12/1
N2 - The incidence of patients with multiple primary tumors has been increasing in recent years. The association between non-Hodgkin lymphomas (NHL) and renal cell carcinoma (RCC) is unclear. The presentation of 10 patients with co-existent NHL and RCC at our institution in the past 3 years led us to explore whether this was a chance association or a statistically significant phenomenon. We used the US Surveillance, Epidemiology and End Results (SEER) program (www.seer.cancer.gov) from 1973 to 2006 to identify a total of 892 445 537 subjects aged 1884, with known values for race and gender at risk for NHL and RCC. Among these, 181 009 were diagnosed with NHL, 118 122 were diagnosed with RCC and 1039 had both NHL and RCC. This was significantly higher than the expected number of 24 with co-existent NHL and RCC (p < 0.0001). The observed number (O) of RCC after NHL was significantly higher than the expected number (E) (O/E: 1.51; 95% confidence interval [CI] 1.361.66), with the O/E ratio remaining elevated across the various follow-up time intervals. The observed number of NHL after RCC was not significantly different from the expected number (O/E: 1.09; 95% CI 0.981.22). In univariate analyses, race and gender were significantly associated with an increased cumulative incidence of RCC after NHL. Multivariate analysis with age, race and gender revealed that white males had a higher cumulative incidence of RCC after NHL. These findings suggest that patients with NHL are at increased risk for RCC.
AB - The incidence of patients with multiple primary tumors has been increasing in recent years. The association between non-Hodgkin lymphomas (NHL) and renal cell carcinoma (RCC) is unclear. The presentation of 10 patients with co-existent NHL and RCC at our institution in the past 3 years led us to explore whether this was a chance association or a statistically significant phenomenon. We used the US Surveillance, Epidemiology and End Results (SEER) program (www.seer.cancer.gov) from 1973 to 2006 to identify a total of 892 445 537 subjects aged 1884, with known values for race and gender at risk for NHL and RCC. Among these, 181 009 were diagnosed with NHL, 118 122 were diagnosed with RCC and 1039 had both NHL and RCC. This was significantly higher than the expected number of 24 with co-existent NHL and RCC (p < 0.0001). The observed number (O) of RCC after NHL was significantly higher than the expected number (E) (O/E: 1.51; 95% confidence interval [CI] 1.361.66), with the O/E ratio remaining elevated across the various follow-up time intervals. The observed number of NHL after RCC was not significantly different from the expected number (O/E: 1.09; 95% CI 0.981.22). In univariate analyses, race and gender were significantly associated with an increased cumulative incidence of RCC after NHL. Multivariate analysis with age, race and gender revealed that white males had a higher cumulative incidence of RCC after NHL. These findings suggest that patients with NHL are at increased risk for RCC.
KW - Non-Hodgkin lymphoma
KW - Renal cell carcinoma
KW - SEER
UR - http://www.scopus.com/inward/record.url?scp=82255192994&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=82255192994&partnerID=8YFLogxK
U2 - 10.3109/10428194.2011.603443
DO - 10.3109/10428194.2011.603443
M3 - Article
C2 - 21740306
AN - SCOPUS:82255192994
VL - 52
SP - 2254
EP - 2261
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
SN - 1042-8194
IS - 12
ER -