The purpose of this study was to identify an association between mitral valve prolapse (MVP) and régurgitation in other cardiac valves. 37,705 consecutive patients who underwent echocardiography at Mount Sinai Medical Center between 1987-1994 were screened for inclusion in this study. MVP was identified in 2783 patients (7.4%). Patients with confounding conditions which could also cause valvular régurgitation such as left ventricular (LV) dysfunction, mitral annular calcification, pulmonary hypertension, pericardial effijsion, and LV hypertrophy were excluded from the study (n=1317). Patients with MVP (n=1366) were compared to an age-sex matched control population (n=1366). The mean age in each group was 56±20 years . The percentage of females was 58.3% in each group There was no difference in LV ejection fraction between the MVP (59.5%±4) and control group (59.2%±5). Aortic régurgitation (AR) occurred more frequently in the MVP group (18%) than the control group (13%) (p < 0.001). The percentage of patients with moderate to severe tricuspid régurgitation (TR) was greater in the MVP group (21%) than the control population (10%) (p <0.0001). The incidence of combined AR and MR was also significantly higher in the MVP group (14%) than the control population (6%) (p<0.0001). MVP is a common finding which is associated with other régurgitant valvular lesions. In a subgroup of patients in this database, there may be a common etiology for MVP, TR, and AR.
|Original language||English (US)|
|Journal||Journal of Investigative Medicine|
|State||Published - Jan 1 1996|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)