Association between low testosterone and anaemia: Analysis of the National Health and Nutrition Examination Survey

David Valancy, Ruben Blachman-Braun, Manish Kuchakulla, Sirpi Nackeeran, Ranjith Ramasamy

Research output: Contribution to journalArticlepeer-review

Abstract

There is an androgen effect on haematopoiesis; however, the effect of low testosterone in anaemia has not been fully studied. In this study, we aim to explore the association of total serum testosterone, low testosterone (≤300 ng/dl), haemoglobin concentration and prevalence of anaemia in a nationally representative sample of men. We analysed data from the NHANES III database, and men between the age of 18–80 years of age were selected. We defined anaemia as haemoglobin ≤13.5 ng/dl and low serum testosterone as ≤300 ng/dl. After analysing 5,888 men, it was shown that those with anaemia had a higher prevalence of low serum testosterone (32.3%) compared to those without anaemia (24.1%) (p <.001), and in multivariable-adjusted analysis, it was shown that low testosterone was significantly associated with anaemia (OR = 1.44; 95% CI: 1.17–1.78; p =.001). Our findings suggest that men with low serum testosterone have a higher risk of anaemia, and there is a positive association between serum testosterone and serum Hb. Further prospective studies need to be performed to confirm our findings.

Original languageEnglish (US)
Article numbere14210
JournalAndrologia
Volume53
Issue number11
DOIs
StatePublished - Dec 2021

Keywords

  • anaemia
  • haemoglobin
  • low testosterone
  • testosterone

ASJC Scopus subject areas

  • Endocrinology
  • Urology

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