Abstract
This study assessed the association between hyaluronic acid (HA) injections and time-to-total knee replacement (TKR) surgery for patients with knee osteoarthritis (OA). Patients 18 to 64 years of age who had TKR surgery between January 1, 2006 and December 31, 2011 were identified from the MarketScan Commercial claims database. All patients had 6 years or more of continuous enrollment prior to TKR surgery. There were two cohorts (1) patients with HA injections prior to TKR surgery and (2) patients who did not have HA injections prior to TKR surgery. Time-to-TKR was defined as the total days from the date of diagnosis of knee OA on the patient's first visit to an orthopedic surgeon to the date of TKR surgery. Results included 22,555 patients who had TKR surgery: 14,132 in the non-HA and 8,423 in the HA cohort. In this retrospective analysis of patients undergoing TKR, the median Time-to-TKR surgery was 326 days for the non-HA and 908 days for the HA cohort, a difference of 582 days. Those receiving HA injections had a median 1.6-year longer Time-to-TKR surgery versus those who did not receive HA injections. These results have both clinical and economic implications.
| Original language | English (US) |
|---|---|
| Journal | The journal of knee surgery |
| DOIs | |
| State | Accepted/In press - Oct 10 2015 |
| Externally published | Yes |
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Keywords
- hyaluronic acid
- knee osteoarthritis
- total knee replacement surgery
- viscosupplementation
ASJC Scopus subject areas
- Surgery
- Orthopedics and Sports Medicine
Cite this
Association between Hyaluronic Acid Injections and Time-to-Total Knee Replacement Surgery. / Altman, Roy D; Fredericson, Michael; Bhattacharyya, Samir K.; Bisson, Brad; Abbott, Thomas; Yadalam, Sashidhar; Kim, Myoung.
In: The journal of knee surgery, 10.10.2015.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association between Hyaluronic Acid Injections and Time-to-Total Knee Replacement Surgery
AU - Altman, Roy D
AU - Fredericson, Michael
AU - Bhattacharyya, Samir K.
AU - Bisson, Brad
AU - Abbott, Thomas
AU - Yadalam, Sashidhar
AU - Kim, Myoung
PY - 2015/10/10
Y1 - 2015/10/10
N2 - This study assessed the association between hyaluronic acid (HA) injections and time-to-total knee replacement (TKR) surgery for patients with knee osteoarthritis (OA). Patients 18 to 64 years of age who had TKR surgery between January 1, 2006 and December 31, 2011 were identified from the MarketScan Commercial claims database. All patients had 6 years or more of continuous enrollment prior to TKR surgery. There were two cohorts (1) patients with HA injections prior to TKR surgery and (2) patients who did not have HA injections prior to TKR surgery. Time-to-TKR was defined as the total days from the date of diagnosis of knee OA on the patient's first visit to an orthopedic surgeon to the date of TKR surgery. Results included 22,555 patients who had TKR surgery: 14,132 in the non-HA and 8,423 in the HA cohort. In this retrospective analysis of patients undergoing TKR, the median Time-to-TKR surgery was 326 days for the non-HA and 908 days for the HA cohort, a difference of 582 days. Those receiving HA injections had a median 1.6-year longer Time-to-TKR surgery versus those who did not receive HA injections. These results have both clinical and economic implications.
AB - This study assessed the association between hyaluronic acid (HA) injections and time-to-total knee replacement (TKR) surgery for patients with knee osteoarthritis (OA). Patients 18 to 64 years of age who had TKR surgery between January 1, 2006 and December 31, 2011 were identified from the MarketScan Commercial claims database. All patients had 6 years or more of continuous enrollment prior to TKR surgery. There were two cohorts (1) patients with HA injections prior to TKR surgery and (2) patients who did not have HA injections prior to TKR surgery. Time-to-TKR was defined as the total days from the date of diagnosis of knee OA on the patient's first visit to an orthopedic surgeon to the date of TKR surgery. Results included 22,555 patients who had TKR surgery: 14,132 in the non-HA and 8,423 in the HA cohort. In this retrospective analysis of patients undergoing TKR, the median Time-to-TKR surgery was 326 days for the non-HA and 908 days for the HA cohort, a difference of 582 days. Those receiving HA injections had a median 1.6-year longer Time-to-TKR surgery versus those who did not receive HA injections. These results have both clinical and economic implications.
KW - hyaluronic acid
KW - knee osteoarthritis
KW - total knee replacement surgery
KW - viscosupplementation
UR - http://www.scopus.com/inward/record.url?scp=84949844785&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84949844785&partnerID=8YFLogxK
U2 - 10.1055/s-0035-1568992
DO - 10.1055/s-0035-1568992
M3 - Article
C2 - 26641076
AN - SCOPUS:84949844785
JO - Journal of Knee Surgery
JF - Journal of Knee Surgery
SN - 1538-8506
ER -