Abstract
The association between the growth of geographic atrophy (GA) and a single nucleotide polymorphism (SNP) in the complement factor I (CFI) locus was investigated in the COMPLETE trial. Growth of GA at 52 weeks in eyes without the CFI at-risk allele was slightly faster than the growth in eyes with the CFI at-risk allele (P≥.72). The authors of the current study found that in contrast to the faster growth rate reported in CFI-positive eyes from the MAHALO trial, the CFI positive eyes in the COMPLETE trial did not grow faster, and this analysis included 24 eyes that met the MAHALO eligibility criteria.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 772-774 |
| Number of pages | 3 |
| Journal | Ophthalmic Surgery Lasers and Imaging Retina |
| Volume | 46 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 1 2015 |
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ASJC Scopus subject areas
- Ophthalmology
- Surgery
Cite this
Association between Growth of Geographic Atrophy and the Complement Factor i Locus. / Yehoshua, Zohar; De Amorim Garcia Filho, Carlos Alexandre; Nunes, Renata Portella; Gregori, Giovanni; Penha, Fernando M.; Moshfeghi, Andrew A.; Luo, Hongrong; Kang, Zhang; Sadda, Srinivas; Feuer, William J; Rosenfeld, Philip J.
In: Ophthalmic Surgery Lasers and Imaging Retina, Vol. 46, No. 7, 01.07.2015, p. 772-774.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association between Growth of Geographic Atrophy and the Complement Factor i Locus
AU - Yehoshua, Zohar
AU - De Amorim Garcia Filho, Carlos Alexandre
AU - Nunes, Renata Portella
AU - Gregori, Giovanni
AU - Penha, Fernando M.
AU - Moshfeghi, Andrew A.
AU - Luo, Hongrong
AU - Kang, Zhang
AU - Sadda, Srinivas
AU - Feuer, William J
AU - Rosenfeld, Philip J
PY - 2015/7/1
Y1 - 2015/7/1
N2 - The association between the growth of geographic atrophy (GA) and a single nucleotide polymorphism (SNP) in the complement factor I (CFI) locus was investigated in the COMPLETE trial. Growth of GA at 52 weeks in eyes without the CFI at-risk allele was slightly faster than the growth in eyes with the CFI at-risk allele (P≥.72). The authors of the current study found that in contrast to the faster growth rate reported in CFI-positive eyes from the MAHALO trial, the CFI positive eyes in the COMPLETE trial did not grow faster, and this analysis included 24 eyes that met the MAHALO eligibility criteria.
AB - The association between the growth of geographic atrophy (GA) and a single nucleotide polymorphism (SNP) in the complement factor I (CFI) locus was investigated in the COMPLETE trial. Growth of GA at 52 weeks in eyes without the CFI at-risk allele was slightly faster than the growth in eyes with the CFI at-risk allele (P≥.72). The authors of the current study found that in contrast to the faster growth rate reported in CFI-positive eyes from the MAHALO trial, the CFI positive eyes in the COMPLETE trial did not grow faster, and this analysis included 24 eyes that met the MAHALO eligibility criteria.
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UR - http://www.scopus.com/inward/citedby.url?scp=84939426489&partnerID=8YFLogxK
U2 - 10.3928/23258160-20150730-15
DO - 10.3928/23258160-20150730-15
M3 - Article
C2 - 26247461
AN - SCOPUS:84939426489
VL - 46
SP - 772
EP - 774
JO - Ophthalmic Surgery Lasers and Imaging Retina
JF - Ophthalmic Surgery Lasers and Imaging Retina
SN - 2325-8160
IS - 7
ER -