Association between Growth of Geographic Atrophy and the Complement Factor i Locus

Zohar Yehoshua, Carlos Alexandre De Amorim Garcia Filho, Renata Portella Nunes, Giovanni Gregori, Fernando M. Penha, Andrew A. Moshfeghi, Hongrong Luo, Zhang Kang, Srinivas Sadda, William J Feuer, Philip J Rosenfeld

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The association between the growth of geographic atrophy (GA) and a single nucleotide polymorphism (SNP) in the complement factor I (CFI) locus was investigated in the COMPLETE trial. Growth of GA at 52 weeks in eyes without the CFI at-risk allele was slightly faster than the growth in eyes with the CFI at-risk allele (P≥.72). The authors of the current study found that in contrast to the faster growth rate reported in CFI-positive eyes from the MAHALO trial, the CFI positive eyes in the COMPLETE trial did not grow faster, and this analysis included 24 eyes that met the MAHALO eligibility criteria.

Original languageEnglish (US)
Pages (from-to)772-774
Number of pages3
JournalOphthalmic Surgery Lasers and Imaging Retina
Volume46
Issue number7
DOIs
StatePublished - Jul 1 2015

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Complement Factor I
Geographic Atrophy
Growth
Alleles
Single Nucleotide Polymorphism

ASJC Scopus subject areas

  • Ophthalmology
  • Surgery

Cite this

Association between Growth of Geographic Atrophy and the Complement Factor i Locus. / Yehoshua, Zohar; De Amorim Garcia Filho, Carlos Alexandre; Nunes, Renata Portella; Gregori, Giovanni; Penha, Fernando M.; Moshfeghi, Andrew A.; Luo, Hongrong; Kang, Zhang; Sadda, Srinivas; Feuer, William J; Rosenfeld, Philip J.

In: Ophthalmic Surgery Lasers and Imaging Retina, Vol. 46, No. 7, 01.07.2015, p. 772-774.

Research output: Contribution to journalArticle

Yehoshua, Z, De Amorim Garcia Filho, CA, Nunes, RP, Gregori, G, Penha, FM, Moshfeghi, AA, Luo, H, Kang, Z, Sadda, S, Feuer, WJ & Rosenfeld, PJ 2015, 'Association between Growth of Geographic Atrophy and the Complement Factor i Locus', Ophthalmic Surgery Lasers and Imaging Retina, vol. 46, no. 7, pp. 772-774. https://doi.org/10.3928/23258160-20150730-15
Yehoshua, Zohar ; De Amorim Garcia Filho, Carlos Alexandre ; Nunes, Renata Portella ; Gregori, Giovanni ; Penha, Fernando M. ; Moshfeghi, Andrew A. ; Luo, Hongrong ; Kang, Zhang ; Sadda, Srinivas ; Feuer, William J ; Rosenfeld, Philip J. / Association between Growth of Geographic Atrophy and the Complement Factor i Locus. In: Ophthalmic Surgery Lasers and Imaging Retina. 2015 ; Vol. 46, No. 7. pp. 772-774.
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