Association between Growth of Geographic Atrophy and the Complement Factor i Locus

Zohar Yehoshua, Carlos Alexandre De Amorim Garcia Filho, Renata Portella Nunes, Giovanni Gregori, Fernando M. Penha, Andrew A. Moshfeghi, Hongrong Luo, Zhang Kang, Srinivas Sadda, William J Feuer, Philip J. Rosenfeld

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


The association between the growth of geographic atrophy (GA) and a single nucleotide polymorphism (SNP) in the complement factor I (CFI) locus was investigated in the COMPLETE trial. Growth of GA at 52 weeks in eyes without the CFI at-risk allele was slightly faster than the growth in eyes with the CFI at-risk allele (P≥.72). The authors of the current study found that in contrast to the faster growth rate reported in CFI-positive eyes from the MAHALO trial, the CFI positive eyes in the COMPLETE trial did not grow faster, and this analysis included 24 eyes that met the MAHALO eligibility criteria.

Original languageEnglish (US)
Pages (from-to)772-774
Number of pages3
JournalOphthalmic Surgery Lasers and Imaging Retina
Issue number7
StatePublished - Jul 1 2015

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology


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