Association between Growth of Geographic Atrophy and the Complement Factor i Locus

Zohar Yehoshua; Carlos Alexandre De Amorim Garcia Filho; Renata Portella Nunes; Giovanni Gregori; Fernando M. Penha; Andrew A. Moshfeghi; Hongrong Luo; Zhang Kang; Srinivas Sadda; William Feuer; Philip J. Rosenfeld

doi:10.3928/23258160-20150730-15

Association between Growth of Geographic Atrophy and the Complement Factor i Locus

Zohar Yehoshua, Carlos Alexandre De Amorim Garcia Filho, Renata Portella Nunes, Giovanni Gregori, Fernando M. Penha, Andrew A. Moshfeghi, Hongrong Luo, Zhang Kang, Srinivas Sadda, William Feuer, Philip J. Rosenfeld

Ophthalmology

Research output: Contribution to journal › Article

8 Scopus citations

Abstract

The association between the growth of geographic atrophy (GA) and a single nucleotide polymorphism (SNP) in the complement factor I (CFI) locus was investigated in the COMPLETE trial. Growth of GA at 52 weeks in eyes without the CFI at-risk allele was slightly faster than the growth in eyes with the CFI at-risk allele (P≥.72). The authors of the current study found that in contrast to the faster growth rate reported in CFI-positive eyes from the MAHALO trial, the CFI positive eyes in the COMPLETE trial did not grow faster, and this analysis included 24 eyes that met the MAHALO eligibility criteria.

Original language	English (US)
Pages (from-to)	772-774
Number of pages	3
Journal	Ophthalmic Surgery Lasers and Imaging Retina
Volume	46
Issue number	7
DOIs	https://doi.org/10.3928/23258160-20150730-15
State	Published - Jul 1 2015

ASJC Scopus subject areas

Surgery
Ophthalmology

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Yehoshua, Z., De Amorim Garcia Filho, C. A., Nunes, R. P., Gregori, G., Penha, F. M., Moshfeghi, A. A., Luo, H., Kang, Z., Sadda, S., Feuer, W., & Rosenfeld, P. J. (2015). Association between Growth of Geographic Atrophy and the Complement Factor i Locus. Ophthalmic Surgery Lasers and Imaging Retina, 46(7), 772-774. https://doi.org/10.3928/23258160-20150730-15

Association between Growth of Geographic Atrophy and the Complement Factor i Locus. / Yehoshua, Zohar; De Amorim Garcia Filho, Carlos Alexandre; Nunes, Renata Portella; Gregori, Giovanni; Penha, Fernando M.; Moshfeghi, Andrew A.; Luo, Hongrong; Kang, Zhang; Sadda, Srinivas; Feuer, William; Rosenfeld, Philip J.

In: Ophthalmic Surgery Lasers and Imaging Retina, Vol. 46, No. 7, 01.07.2015, p. 772-774.

Research output: Contribution to journal › Article

Yehoshua, Zohar ; De Amorim Garcia Filho, Carlos Alexandre ; Nunes, Renata Portella ; Gregori, Giovanni ; Penha, Fernando M. ; Moshfeghi, Andrew A. ; Luo, Hongrong ; Kang, Zhang ; Sadda, Srinivas ; Feuer, William ; Rosenfeld, Philip J. / Association between Growth of Geographic Atrophy and the Complement Factor i Locus. In: Ophthalmic Surgery Lasers and Imaging Retina. 2015 ; Vol. 46, No. 7. pp. 772-774.

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abstract = "The association between the growth of geographic atrophy (GA) and a single nucleotide polymorphism (SNP) in the complement factor I (CFI) locus was investigated in the COMPLETE trial. Growth of GA at 52 weeks in eyes without the CFI at-risk allele was slightly faster than the growth in eyes with the CFI at-risk allele (P≥.72). The authors of the current study found that in contrast to the faster growth rate reported in CFI-positive eyes from the MAHALO trial, the CFI positive eyes in the COMPLETE trial did not grow faster, and this analysis included 24 eyes that met the MAHALO eligibility criteria.",

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