Association between endothelial dysfunction, epicardial fat and sub-clinical atherosclerosis during menopause

Julio Oscar Cabrera-Rego, Daisy Navarro-Despaigne, Liudmila Staroushik-Morel, Karel Díaz-Reyes, Marcos M. Lima-Martínez, Gianluca Iacobellis

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Menopausal transition is critical for the development of early, subclinical vascular damage. Multiple factors, such as atherosclerosis, increased epicardial fat, and endothelial dysfunction can play a role. Hence, the objective of this study was the comparison of epicardial adipose tissue and carotid intima media thickness in order to establish the best predictor of carotid stiffness in middle-aged women with endothelial dysfunction. Methods: A total of 43 healthy women aged 40-59 years old with endothelial dysfunction previously demonstrated by flow mediated dilation were recruited to have anthropometric, biochemical, hormonal and ultrasound determinations of carotid intima media thickness and epicardial fat thickness. Results: Carotid arterial stiffness parameters (local pulse wave velocity [4.7. ±. 0.7 vs 4.8. ±. 0.5 vs 5.6. ±. 0.5. m/s, respectively, p <. 0.001], pressure strain elastic modulus [55.2. ±. 13.4 vs 59.2. ±. 11.8 vs 81.9. ±. 15.6. kPa, respectively, p <. 0.001], arterial stiffness index β [4.4. ±. 1.4 vs 5.0. ±. 1.1 vs 6.4. ±. 1.3, respectively, p <. 0.001]) and epicardial fat thickness (2.98. ±. 1.4 vs 3.28. ±. 1.9 vs 4.70. ±. 1.0. mm, respectively, p = 0.007) showed a significant and proportional increase in the group of late post-menopausal women when compared to early post-menopausal and pre-menopausal groups, respectively. Among body fat markers, epicardial fat was the strongest predictor of local pulse wave velocity, independent of age. Conclusions: In menopausal women with endothelial dysfunction, menopausal transition is associated with increased carotid arterial stiffness and epicardial fat thickness, independent of age. Ultrasound measured epicardial fat was a better independent predictor of arterial stiffness than carotid intima media thickness in these women.

Original languageEnglish (US)
JournalClinica e Investigacion en Arteriosclerosis
DOIs
StateAccepted/In press - 2017

Fingerprint

Menopause
Atherosclerosis
Vascular Stiffness
Fats
Carotid Intima-Media Thickness
Pulse Wave Analysis
Adipose Tissue
Elastic Modulus
Blood Vessels
Dilatation
Pressure

Keywords

  • Arterial stiffness
  • Carotid intima-media thickness
  • Endothelial dysfunction
  • Epicardial fat
  • Menopause

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

Cite this

Association between endothelial dysfunction, epicardial fat and sub-clinical atherosclerosis during menopause. / Cabrera-Rego, Julio Oscar; Navarro-Despaigne, Daisy; Staroushik-Morel, Liudmila; Díaz-Reyes, Karel; Lima-Martínez, Marcos M.; Iacobellis, Gianluca.

In: Clinica e Investigacion en Arteriosclerosis, 2017.

Research output: Contribution to journalArticle

Cabrera-Rego, Julio Oscar ; Navarro-Despaigne, Daisy ; Staroushik-Morel, Liudmila ; Díaz-Reyes, Karel ; Lima-Martínez, Marcos M. ; Iacobellis, Gianluca. / Association between endothelial dysfunction, epicardial fat and sub-clinical atherosclerosis during menopause. In: Clinica e Investigacion en Arteriosclerosis. 2017.
@article{2b4a8d561dd54d769ab36c7b84628962,
title = "Association between endothelial dysfunction, epicardial fat and sub-clinical atherosclerosis during menopause",
abstract = "Background: Menopausal transition is critical for the development of early, subclinical vascular damage. Multiple factors, such as atherosclerosis, increased epicardial fat, and endothelial dysfunction can play a role. Hence, the objective of this study was the comparison of epicardial adipose tissue and carotid intima media thickness in order to establish the best predictor of carotid stiffness in middle-aged women with endothelial dysfunction. Methods: A total of 43 healthy women aged 40-59 years old with endothelial dysfunction previously demonstrated by flow mediated dilation were recruited to have anthropometric, biochemical, hormonal and ultrasound determinations of carotid intima media thickness and epicardial fat thickness. Results: Carotid arterial stiffness parameters (local pulse wave velocity [4.7. ±. 0.7 vs 4.8. ±. 0.5 vs 5.6. ±. 0.5. m/s, respectively, p <. 0.001], pressure strain elastic modulus [55.2. ±. 13.4 vs 59.2. ±. 11.8 vs 81.9. ±. 15.6. kPa, respectively, p <. 0.001], arterial stiffness index β [4.4. ±. 1.4 vs 5.0. ±. 1.1 vs 6.4. ±. 1.3, respectively, p <. 0.001]) and epicardial fat thickness (2.98. ±. 1.4 vs 3.28. ±. 1.9 vs 4.70. ±. 1.0. mm, respectively, p = 0.007) showed a significant and proportional increase in the group of late post-menopausal women when compared to early post-menopausal and pre-menopausal groups, respectively. Among body fat markers, epicardial fat was the strongest predictor of local pulse wave velocity, independent of age. Conclusions: In menopausal women with endothelial dysfunction, menopausal transition is associated with increased carotid arterial stiffness and epicardial fat thickness, independent of age. Ultrasound measured epicardial fat was a better independent predictor of arterial stiffness than carotid intima media thickness in these women.",
keywords = "Arterial stiffness, Carotid intima-media thickness, Endothelial dysfunction, Epicardial fat, Menopause",
author = "Cabrera-Rego, {Julio Oscar} and Daisy Navarro-Despaigne and Liudmila Staroushik-Morel and Karel D{\'i}az-Reyes and Lima-Mart{\'i}nez, {Marcos M.} and Gianluca Iacobellis",
year = "2017",
doi = "10.1016/j.arteri.2017.07.006",
language = "English (US)",
journal = "Clinica e Investigacion en Arteriosclerosis",
issn = "0214-9168",
publisher = "Ediciones Doyma, S.L.",

}

TY - JOUR

T1 - Association between endothelial dysfunction, epicardial fat and sub-clinical atherosclerosis during menopause

AU - Cabrera-Rego, Julio Oscar

AU - Navarro-Despaigne, Daisy

AU - Staroushik-Morel, Liudmila

AU - Díaz-Reyes, Karel

AU - Lima-Martínez, Marcos M.

AU - Iacobellis, Gianluca

PY - 2017

Y1 - 2017

N2 - Background: Menopausal transition is critical for the development of early, subclinical vascular damage. Multiple factors, such as atherosclerosis, increased epicardial fat, and endothelial dysfunction can play a role. Hence, the objective of this study was the comparison of epicardial adipose tissue and carotid intima media thickness in order to establish the best predictor of carotid stiffness in middle-aged women with endothelial dysfunction. Methods: A total of 43 healthy women aged 40-59 years old with endothelial dysfunction previously demonstrated by flow mediated dilation were recruited to have anthropometric, biochemical, hormonal and ultrasound determinations of carotid intima media thickness and epicardial fat thickness. Results: Carotid arterial stiffness parameters (local pulse wave velocity [4.7. ±. 0.7 vs 4.8. ±. 0.5 vs 5.6. ±. 0.5. m/s, respectively, p <. 0.001], pressure strain elastic modulus [55.2. ±. 13.4 vs 59.2. ±. 11.8 vs 81.9. ±. 15.6. kPa, respectively, p <. 0.001], arterial stiffness index β [4.4. ±. 1.4 vs 5.0. ±. 1.1 vs 6.4. ±. 1.3, respectively, p <. 0.001]) and epicardial fat thickness (2.98. ±. 1.4 vs 3.28. ±. 1.9 vs 4.70. ±. 1.0. mm, respectively, p = 0.007) showed a significant and proportional increase in the group of late post-menopausal women when compared to early post-menopausal and pre-menopausal groups, respectively. Among body fat markers, epicardial fat was the strongest predictor of local pulse wave velocity, independent of age. Conclusions: In menopausal women with endothelial dysfunction, menopausal transition is associated with increased carotid arterial stiffness and epicardial fat thickness, independent of age. Ultrasound measured epicardial fat was a better independent predictor of arterial stiffness than carotid intima media thickness in these women.

AB - Background: Menopausal transition is critical for the development of early, subclinical vascular damage. Multiple factors, such as atherosclerosis, increased epicardial fat, and endothelial dysfunction can play a role. Hence, the objective of this study was the comparison of epicardial adipose tissue and carotid intima media thickness in order to establish the best predictor of carotid stiffness in middle-aged women with endothelial dysfunction. Methods: A total of 43 healthy women aged 40-59 years old with endothelial dysfunction previously demonstrated by flow mediated dilation were recruited to have anthropometric, biochemical, hormonal and ultrasound determinations of carotid intima media thickness and epicardial fat thickness. Results: Carotid arterial stiffness parameters (local pulse wave velocity [4.7. ±. 0.7 vs 4.8. ±. 0.5 vs 5.6. ±. 0.5. m/s, respectively, p <. 0.001], pressure strain elastic modulus [55.2. ±. 13.4 vs 59.2. ±. 11.8 vs 81.9. ±. 15.6. kPa, respectively, p <. 0.001], arterial stiffness index β [4.4. ±. 1.4 vs 5.0. ±. 1.1 vs 6.4. ±. 1.3, respectively, p <. 0.001]) and epicardial fat thickness (2.98. ±. 1.4 vs 3.28. ±. 1.9 vs 4.70. ±. 1.0. mm, respectively, p = 0.007) showed a significant and proportional increase in the group of late post-menopausal women when compared to early post-menopausal and pre-menopausal groups, respectively. Among body fat markers, epicardial fat was the strongest predictor of local pulse wave velocity, independent of age. Conclusions: In menopausal women with endothelial dysfunction, menopausal transition is associated with increased carotid arterial stiffness and epicardial fat thickness, independent of age. Ultrasound measured epicardial fat was a better independent predictor of arterial stiffness than carotid intima media thickness in these women.

KW - Arterial stiffness

KW - Carotid intima-media thickness

KW - Endothelial dysfunction

KW - Epicardial fat

KW - Menopause

UR - http://www.scopus.com/inward/record.url?scp=85029604148&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85029604148&partnerID=8YFLogxK

U2 - 10.1016/j.arteri.2017.07.006

DO - 10.1016/j.arteri.2017.07.006

M3 - Article

C2 - 28939053

AN - SCOPUS:85029604148

JO - Clinica e Investigacion en Arteriosclerosis

JF - Clinica e Investigacion en Arteriosclerosis

SN - 0214-9168

ER -