Abstract
Background: Menopausal transition is critical for the development of early, subclinical vascular damage. Multiple factors, such as atherosclerosis, increased epicardial fat, and endothelial dysfunction can play a role. Hence, the objective of this study was the comparison of epicardial adipose tissue and carotid intima media thickness in order to establish the best predictor of carotid stiffness in middle-aged women with endothelial dysfunction. Methods: A total of 43 healthy women aged 40-59 years old with endothelial dysfunction previously demonstrated by flow mediated dilation were recruited to have anthropometric, biochemical, hormonal and ultrasound determinations of carotid intima media thickness and epicardial fat thickness. Results: Carotid arterial stiffness parameters (local pulse wave velocity [4.7. ±. 0.7 vs 4.8. ±. 0.5 vs 5.6. ±. 0.5. m/s, respectively, p <. 0.001], pressure strain elastic modulus [55.2. ±. 13.4 vs 59.2. ±. 11.8 vs 81.9. ±. 15.6. kPa, respectively, p <. 0.001], arterial stiffness index β [4.4. ±. 1.4 vs 5.0. ±. 1.1 vs 6.4. ±. 1.3, respectively, p <. 0.001]) and epicardial fat thickness (2.98. ±. 1.4 vs 3.28. ±. 1.9 vs 4.70. ±. 1.0. mm, respectively, p = 0.007) showed a significant and proportional increase in the group of late post-menopausal women when compared to early post-menopausal and pre-menopausal groups, respectively. Among body fat markers, epicardial fat was the strongest predictor of local pulse wave velocity, independent of age. Conclusions: In menopausal women with endothelial dysfunction, menopausal transition is associated with increased carotid arterial stiffness and epicardial fat thickness, independent of age. Ultrasound measured epicardial fat was a better independent predictor of arterial stiffness than carotid intima media thickness in these women.
| Original language | English (US) |
|---|---|
| Journal | Clinica e Investigacion en Arteriosclerosis |
| DOIs | |
| State | Accepted/In press - 2017 |
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Keywords
- Arterial stiffness
- Carotid intima-media thickness
- Endothelial dysfunction
- Epicardial fat
- Menopause
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Pharmacology (medical)
Cite this
Association between endothelial dysfunction, epicardial fat and sub-clinical atherosclerosis during menopause. / Cabrera-Rego, Julio Oscar; Navarro-Despaigne, Daisy; Staroushik-Morel, Liudmila; Díaz-Reyes, Karel; Lima-Martínez, Marcos M.; Iacobellis, Gianluca.
In: Clinica e Investigacion en Arteriosclerosis, 2017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association between endothelial dysfunction, epicardial fat and sub-clinical atherosclerosis during menopause
AU - Cabrera-Rego, Julio Oscar
AU - Navarro-Despaigne, Daisy
AU - Staroushik-Morel, Liudmila
AU - Díaz-Reyes, Karel
AU - Lima-Martínez, Marcos M.
AU - Iacobellis, Gianluca
PY - 2017
Y1 - 2017
N2 - Background: Menopausal transition is critical for the development of early, subclinical vascular damage. Multiple factors, such as atherosclerosis, increased epicardial fat, and endothelial dysfunction can play a role. Hence, the objective of this study was the comparison of epicardial adipose tissue and carotid intima media thickness in order to establish the best predictor of carotid stiffness in middle-aged women with endothelial dysfunction. Methods: A total of 43 healthy women aged 40-59 years old with endothelial dysfunction previously demonstrated by flow mediated dilation were recruited to have anthropometric, biochemical, hormonal and ultrasound determinations of carotid intima media thickness and epicardial fat thickness. Results: Carotid arterial stiffness parameters (local pulse wave velocity [4.7. ±. 0.7 vs 4.8. ±. 0.5 vs 5.6. ±. 0.5. m/s, respectively, p <. 0.001], pressure strain elastic modulus [55.2. ±. 13.4 vs 59.2. ±. 11.8 vs 81.9. ±. 15.6. kPa, respectively, p <. 0.001], arterial stiffness index β [4.4. ±. 1.4 vs 5.0. ±. 1.1 vs 6.4. ±. 1.3, respectively, p <. 0.001]) and epicardial fat thickness (2.98. ±. 1.4 vs 3.28. ±. 1.9 vs 4.70. ±. 1.0. mm, respectively, p = 0.007) showed a significant and proportional increase in the group of late post-menopausal women when compared to early post-menopausal and pre-menopausal groups, respectively. Among body fat markers, epicardial fat was the strongest predictor of local pulse wave velocity, independent of age. Conclusions: In menopausal women with endothelial dysfunction, menopausal transition is associated with increased carotid arterial stiffness and epicardial fat thickness, independent of age. Ultrasound measured epicardial fat was a better independent predictor of arterial stiffness than carotid intima media thickness in these women.
AB - Background: Menopausal transition is critical for the development of early, subclinical vascular damage. Multiple factors, such as atherosclerosis, increased epicardial fat, and endothelial dysfunction can play a role. Hence, the objective of this study was the comparison of epicardial adipose tissue and carotid intima media thickness in order to establish the best predictor of carotid stiffness in middle-aged women with endothelial dysfunction. Methods: A total of 43 healthy women aged 40-59 years old with endothelial dysfunction previously demonstrated by flow mediated dilation were recruited to have anthropometric, biochemical, hormonal and ultrasound determinations of carotid intima media thickness and epicardial fat thickness. Results: Carotid arterial stiffness parameters (local pulse wave velocity [4.7. ±. 0.7 vs 4.8. ±. 0.5 vs 5.6. ±. 0.5. m/s, respectively, p <. 0.001], pressure strain elastic modulus [55.2. ±. 13.4 vs 59.2. ±. 11.8 vs 81.9. ±. 15.6. kPa, respectively, p <. 0.001], arterial stiffness index β [4.4. ±. 1.4 vs 5.0. ±. 1.1 vs 6.4. ±. 1.3, respectively, p <. 0.001]) and epicardial fat thickness (2.98. ±. 1.4 vs 3.28. ±. 1.9 vs 4.70. ±. 1.0. mm, respectively, p = 0.007) showed a significant and proportional increase in the group of late post-menopausal women when compared to early post-menopausal and pre-menopausal groups, respectively. Among body fat markers, epicardial fat was the strongest predictor of local pulse wave velocity, independent of age. Conclusions: In menopausal women with endothelial dysfunction, menopausal transition is associated with increased carotid arterial stiffness and epicardial fat thickness, independent of age. Ultrasound measured epicardial fat was a better independent predictor of arterial stiffness than carotid intima media thickness in these women.
KW - Arterial stiffness
KW - Carotid intima-media thickness
KW - Endothelial dysfunction
KW - Epicardial fat
KW - Menopause
UR - http://www.scopus.com/inward/record.url?scp=85029604148&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85029604148&partnerID=8YFLogxK
U2 - 10.1016/j.arteri.2017.07.006
DO - 10.1016/j.arteri.2017.07.006
M3 - Article
C2 - 28939053
AN - SCOPUS:85029604148
JO - Clinica e Investigacion en Arteriosclerosis
JF - Clinica e Investigacion en Arteriosclerosis
SN - 0214-9168
ER -