Association between culturable human immunodeficiency virus type 1 (HIV- 1) in semen and HIV-1 RNA levels in semen and blood: Evidence for compartmentalization of HIV-1 between semen and blood

Robert W. Coombs, Carl E. Speck, James P. Hughes, Willa Lee, Reigran Sampoleo, Susan O. Ross, Joan Dragavon, Greg Peterson, Thomas Hooton, Ann C. Collier, Lawrence Corey, Laura Koutsky, John N. Krieger

Research output: Contribution to journalArticle

258 Citations (Scopus)

Abstract

Both qualitative and quantitative virologic measurements were compared between blood and genital compartments for 128 men infected with human immunodeficiency virus type 1 (HIV-1) to address several controversial issues concerning HIV-1 shedding in semen and to obtain further information about the distribution of virus between these two compartments. Evidence for viral compartmentalization was suggested by earlier studies that noted the poor correlation between blood and seminal virus load, phenotype, and genotype. Further support for this viral compartmentalization was based on the following observations between semen and blood: lack of association between culturability of virus in semen and viral RNA level in blood, discordant distribution of viral phenotypes, discordant viral RNA levels, a weak correlation between viral RNA level in semen and CD4 cell count in blood, differences in the biologic variability of viral RNA levels, and differences in the virus load response to antiretroviral therapy.

Original languageEnglish
Pages (from-to)320-330
Number of pages11
JournalJournal of Infectious Diseases
Volume177
Issue number2
StatePublished - Feb 16 1998
Externally publishedYes

Fingerprint

Semen
Viral RNA
HIV-1
RNA
Viruses
Virus Shedding
Phenotype
Information Dissemination
CD4 Lymphocyte Count
Genotype
Therapeutics

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Association between culturable human immunodeficiency virus type 1 (HIV- 1) in semen and HIV-1 RNA levels in semen and blood : Evidence for compartmentalization of HIV-1 between semen and blood. / Coombs, Robert W.; Speck, Carl E.; Hughes, James P.; Lee, Willa; Sampoleo, Reigran; Ross, Susan O.; Dragavon, Joan; Peterson, Greg; Hooton, Thomas; Collier, Ann C.; Corey, Lawrence; Koutsky, Laura; Krieger, John N.

In: Journal of Infectious Diseases, Vol. 177, No. 2, 16.02.1998, p. 320-330.

Research output: Contribution to journalArticle

Coombs, RW, Speck, CE, Hughes, JP, Lee, W, Sampoleo, R, Ross, SO, Dragavon, J, Peterson, G, Hooton, T, Collier, AC, Corey, L, Koutsky, L & Krieger, JN 1998, 'Association between culturable human immunodeficiency virus type 1 (HIV- 1) in semen and HIV-1 RNA levels in semen and blood: Evidence for compartmentalization of HIV-1 between semen and blood', Journal of Infectious Diseases, vol. 177, no. 2, pp. 320-330.
Coombs, Robert W. ; Speck, Carl E. ; Hughes, James P. ; Lee, Willa ; Sampoleo, Reigran ; Ross, Susan O. ; Dragavon, Joan ; Peterson, Greg ; Hooton, Thomas ; Collier, Ann C. ; Corey, Lawrence ; Koutsky, Laura ; Krieger, John N. / Association between culturable human immunodeficiency virus type 1 (HIV- 1) in semen and HIV-1 RNA levels in semen and blood : Evidence for compartmentalization of HIV-1 between semen and blood. In: Journal of Infectious Diseases. 1998 ; Vol. 177, No. 2. pp. 320-330.
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