Abstract
To examine the relationship between corneal biomechanical properties and the degree of myopia. Methods Chinese subjects (n=172, age: 11-65 years) were divided into diagnostic groups with non-myopia (spherical equivalence (SE)<-0.50 D), low (-3.00≥SE≥-0.50 D), moderate (-6.00≥SE≥-3.00 D), and high myopia (SE>-6.00 D). Only the right eye of each subject was analyzed. Central corneal thickness (CCT) was measured by optical coherence tomography. An ocular response analyzer was used to measure corneal hysteresis (CH), corneal resistance factor (CRF), intraocular pressure (IOP), and corneal compensated IOP (IOPcc). Refraction was measured by both automated and subjective refractometry and expressed as SE. Results CH was significantly lower in high myopia compared with both low and non-myopia (P≥0.002). CCT was 1.5 times more correlated to CH variation compared with refraction. Similarly, CRF was four times more dependent on CCT than refraction. CH (P>0.001) or CRF (P=0.005) was positively correlated to refraction. Both IOP and IOPcc were negatively correlated to refraction (P>0.001), respectively. Conclusions CH decreases only in high myopia. Refraction is positively correlated to both CH and CRF but negatively correlated to both IOP and IOPcc. These results indicate that the mechanical strength in anterior segment of the eye is compromised in high myopia. In addition, high myopia may increase the risk of glaucoma.
| Original language | English |
|---|---|
| Pages (from-to) | 1083-1089 |
| Number of pages | 7 |
| Journal | Eye |
| Volume | 25 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 1 2011 |
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Keywords
- central corneal thickness
- corneal biomechanical properties
- myopia
ASJC Scopus subject areas
- Ophthalmology
Cite this
Association between corneal biomechanical properties and myopia in Chinese subjects. / Jiang, Z.; Shen, M.; Mao, G.; Chen, D.; Wang, Jianhua; Qu, J.; Lu, F.
In: Eye, Vol. 25, No. 8, 01.08.2011, p. 1083-1089.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association between corneal biomechanical properties and myopia in Chinese subjects
AU - Jiang, Z.
AU - Shen, M.
AU - Mao, G.
AU - Chen, D.
AU - Wang, Jianhua
AU - Qu, J.
AU - Lu, F.
PY - 2011/8/1
Y1 - 2011/8/1
N2 - To examine the relationship between corneal biomechanical properties and the degree of myopia. Methods Chinese subjects (n=172, age: 11-65 years) were divided into diagnostic groups with non-myopia (spherical equivalence (SE)<-0.50 D), low (-3.00≥SE≥-0.50 D), moderate (-6.00≥SE≥-3.00 D), and high myopia (SE>-6.00 D). Only the right eye of each subject was analyzed. Central corneal thickness (CCT) was measured by optical coherence tomography. An ocular response analyzer was used to measure corneal hysteresis (CH), corneal resistance factor (CRF), intraocular pressure (IOP), and corneal compensated IOP (IOPcc). Refraction was measured by both automated and subjective refractometry and expressed as SE. Results CH was significantly lower in high myopia compared with both low and non-myopia (P≥0.002). CCT was 1.5 times more correlated to CH variation compared with refraction. Similarly, CRF was four times more dependent on CCT than refraction. CH (P>0.001) or CRF (P=0.005) was positively correlated to refraction. Both IOP and IOPcc were negatively correlated to refraction (P>0.001), respectively. Conclusions CH decreases only in high myopia. Refraction is positively correlated to both CH and CRF but negatively correlated to both IOP and IOPcc. These results indicate that the mechanical strength in anterior segment of the eye is compromised in high myopia. In addition, high myopia may increase the risk of glaucoma.
AB - To examine the relationship between corneal biomechanical properties and the degree of myopia. Methods Chinese subjects (n=172, age: 11-65 years) were divided into diagnostic groups with non-myopia (spherical equivalence (SE)<-0.50 D), low (-3.00≥SE≥-0.50 D), moderate (-6.00≥SE≥-3.00 D), and high myopia (SE>-6.00 D). Only the right eye of each subject was analyzed. Central corneal thickness (CCT) was measured by optical coherence tomography. An ocular response analyzer was used to measure corneal hysteresis (CH), corneal resistance factor (CRF), intraocular pressure (IOP), and corneal compensated IOP (IOPcc). Refraction was measured by both automated and subjective refractometry and expressed as SE. Results CH was significantly lower in high myopia compared with both low and non-myopia (P≥0.002). CCT was 1.5 times more correlated to CH variation compared with refraction. Similarly, CRF was four times more dependent on CCT than refraction. CH (P>0.001) or CRF (P=0.005) was positively correlated to refraction. Both IOP and IOPcc were negatively correlated to refraction (P>0.001), respectively. Conclusions CH decreases only in high myopia. Refraction is positively correlated to both CH and CRF but negatively correlated to both IOP and IOPcc. These results indicate that the mechanical strength in anterior segment of the eye is compromised in high myopia. In addition, high myopia may increase the risk of glaucoma.
KW - central corneal thickness
KW - corneal biomechanical properties
KW - myopia
UR - http://www.scopus.com/inward/record.url?scp=80051761455&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80051761455&partnerID=8YFLogxK
U2 - 10.1038/eye.2011.104
DO - 10.1038/eye.2011.104
M3 - Article
C2 - 21546923
AN - SCOPUS:80051761455
VL - 25
SP - 1083
EP - 1089
JO - Eye (Basingstoke)
JF - Eye (Basingstoke)
SN - 0950-222X
IS - 8
ER -