Association between bleomycin hydrolase and Alzheimer's disease in Caucasians

Lindsay A. Farrer, Carmela R. Abraham, Jonathan L. Haines, Ekaterina A. Rogaeva, Youqiang Song, Walker T. McGraw, Nicholas Brindle, Smita Premkumar, William K. Scott, Larry H. Yamaoka, Ann M. Saunders, Allen D. Roses, Sanford A. Auerbach, Sandro Sorbi, Ranjan Duara, Margaret A. Pericak-Vance, Peter H. St. George-Hyslop

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


A recent study showed modest evidence for an increased frequency of the bleomycin hydrolase (BH) V/V genotype in Alzheimer's disease (AD) patients compared with non-demented controls. To test this hypothesis, we examined this polymorphism in 621 rigorously evaluated patients and 502 control subjects (all caucasian) but were unable to detect an association between BH and AD even after controlling for age, gender, and apolipoprotein E (ApoE) genotype. We conclude that this polymorphism does not account for inherited susceptibility to AD in the populations represented in this sample.

Original languageEnglish (US)
Pages (from-to)808-811
Number of pages4
JournalAnnals of neurology
Issue number5
StatePublished - Nov 1998

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


Dive into the research topics of 'Association between bleomycin hydrolase and Alzheimer's disease in Caucasians'. Together they form a unique fingerprint.

Cite this