Association between bleomycin hydrolase and Alzheimer's disease in Caucasians

Lindsay A. Farrer, Carmela R. Abraham, Jonathan L. Haines, Ekaterina A. Rogaeva, Youqiang Song, Walker T. McGraw, Nicholas Brindle, Smita Premkumar, William K Scott, Larry H. Yamaoka, Ann M. Saunders, Allen D. Roses, Sanford A. Auerbach, Sandro Sorbi, Ranjan Duara, Margaret A Pericak-Vance, Peter H. St. George-Hyslop

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

A recent study showed modest evidence for an increased frequency of the bleomycin hydrolase (BH) V/V genotype in Alzheimer's disease (AD) patients compared with non-demented controls. To test this hypothesis, we examined this polymorphism in 621 rigorously evaluated patients and 502 control subjects (all caucasian) but were unable to detect an association between BH and AD even after controlling for age, gender, and apolipoprotein E (ApoE) genotype. We conclude that this polymorphism does not account for inherited susceptibility to AD in the populations represented in this sample.

Original languageEnglish
Pages (from-to)808-811
Number of pages4
JournalAnnals of Neurology
Volume44
Issue number5
StatePublished - Nov 1 1998
Externally publishedYes

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Alzheimer Disease
Genotype
Apolipoproteins E
Population
bleomycin hydrolase

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Farrer, L. A., Abraham, C. R., Haines, J. L., Rogaeva, E. A., Song, Y., McGraw, W. T., ... St. George-Hyslop, P. H. (1998). Association between bleomycin hydrolase and Alzheimer's disease in Caucasians. Annals of Neurology, 44(5), 808-811.

Association between bleomycin hydrolase and Alzheimer's disease in Caucasians. / Farrer, Lindsay A.; Abraham, Carmela R.; Haines, Jonathan L.; Rogaeva, Ekaterina A.; Song, Youqiang; McGraw, Walker T.; Brindle, Nicholas; Premkumar, Smita; Scott, William K; Yamaoka, Larry H.; Saunders, Ann M.; Roses, Allen D.; Auerbach, Sanford A.; Sorbi, Sandro; Duara, Ranjan; Pericak-Vance, Margaret A; St. George-Hyslop, Peter H.

In: Annals of Neurology, Vol. 44, No. 5, 01.11.1998, p. 808-811.

Research output: Contribution to journalArticle

Farrer, LA, Abraham, CR, Haines, JL, Rogaeva, EA, Song, Y, McGraw, WT, Brindle, N, Premkumar, S, Scott, WK, Yamaoka, LH, Saunders, AM, Roses, AD, Auerbach, SA, Sorbi, S, Duara, R, Pericak-Vance, MA & St. George-Hyslop, PH 1998, 'Association between bleomycin hydrolase and Alzheimer's disease in Caucasians', Annals of Neurology, vol. 44, no. 5, pp. 808-811.
Farrer LA, Abraham CR, Haines JL, Rogaeva EA, Song Y, McGraw WT et al. Association between bleomycin hydrolase and Alzheimer's disease in Caucasians. Annals of Neurology. 1998 Nov 1;44(5):808-811.
Farrer, Lindsay A. ; Abraham, Carmela R. ; Haines, Jonathan L. ; Rogaeva, Ekaterina A. ; Song, Youqiang ; McGraw, Walker T. ; Brindle, Nicholas ; Premkumar, Smita ; Scott, William K ; Yamaoka, Larry H. ; Saunders, Ann M. ; Roses, Allen D. ; Auerbach, Sanford A. ; Sorbi, Sandro ; Duara, Ranjan ; Pericak-Vance, Margaret A ; St. George-Hyslop, Peter H. / Association between bleomycin hydrolase and Alzheimer's disease in Caucasians. In: Annals of Neurology. 1998 ; Vol. 44, No. 5. pp. 808-811.
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