Association between bleomycin hydrolase and Alzheimer's disease in Caucasians

Lindsay A. Farrer, Carmela R. Abraham, Jonathan L. Haines, Ekaterina A. Rogaeva, Youqiang Song, Walker T. McGraw, Nicholas Brindle, Smita Premkumar, William K. Scott, Larry H. Yamaoka, Ann M. Saunders, Allen D. Roses, Sanford A. Auerbach, Sandro Sorbi, Ranjan Duara, Margaret A. Pericak-Vance, Peter H. St. George-Hyslop

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

A recent study showed modest evidence for an increased frequency of the bleomycin hydrolase (BH) V/V genotype in Alzheimer's disease (AD) patients compared with non-demented controls. To test this hypothesis, we examined this polymorphism in 621 rigorously evaluated patients and 502 control subjects (all caucasian) but were unable to detect an association between BH and AD even after controlling for age, gender, and apolipoprotein E (ApoE) genotype. We conclude that this polymorphism does not account for inherited susceptibility to AD in the populations represented in this sample.

Original languageEnglish (US)
Pages (from-to)808-811
Number of pages4
JournalAnnals of neurology
Volume44
Issue number5
DOIs
StatePublished - Nov 1998

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Farrer, L. A., Abraham, C. R., Haines, J. L., Rogaeva, E. A., Song, Y., McGraw, W. T., Brindle, N., Premkumar, S., Scott, W. K., Yamaoka, L. H., Saunders, A. M., Roses, A. D., Auerbach, S. A., Sorbi, S., Duara, R., Pericak-Vance, M. A., & St. George-Hyslop, P. H. (1998). Association between bleomycin hydrolase and Alzheimer's disease in Caucasians. Annals of neurology, 44(5), 808-811. https://doi.org/10.1002/ana.410440515