Association between anti-human heat shock protein-60 and interleukin-2 with coronary artery calcium score

Abdulla A. Damluji, Archana Ramireddy, Mohammed S. Al-Damluji, George R. Marzouka, Lynda Otalvaro, Juan Viles Gonzalez, Chunming Dong, Carlos E Alfonso, Robert Hendel, Mauricio G Cohen, Mauro Moscucci, Nanette Bishopric, Robert J Myerburg

Research output: Contribution to journalArticle

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Abstract

Introduction Based upon evidence suggesting that concentrations of anti-heat shock protein-60 (anti-HSP60) and interleukin-2 (IL-2) are associated with atherogenesis, we tested the hypothesis that anti-HSP60 and IL-2 are associated with coronary artery calcium (CAC) score, a marker of subclinical atherosclerosis. Methods We evaluated 998 asymptomatic adults, age 45-84 years, without known coronary disease from the Multi-Ethnic Study of Atherosclerosis (MESA), who had anti-HSP60 measured at baseline. Tertiles of serum anti-HSP60 were evaluated. The associations of IL-2 and anti-HSP60 with CAC were assessed using multivariate analyses, with adjustments for coronary risk factors and Framingham risk score. Results Patients' demographics, diabetes, hypertension, obesity, or dyslipidaemia did not show differences in levels of anti-HSP60. The median (IQR) Framingham risk score was 11 (5 -22), 8 (5-16), and 9 (5-18) for the first, second, and third tertiles, respectively ( p=0.043). IL-2 and tumour necrosis factor α (TNF-α) were associated with increased CAC (IL-2: OR 3.70, p<0.001; TNF-α : OR 4.63, p<0.001). In multivariate regression, the highest tertiles of anti-HSP60 and IL-2 were associated with increased risk of CAC (HSP60 T3: OR 1.49, p=0.022; IL-2: OR 2.49, p<0.001). After adjustment, significant progression of CAC was observed in patients with higher baseline levels of anti-HSP60 (estimate 31.73, p=0.016) and IL-2 (estimate 34.39, p=0.024). Conclusions Increased concentrations of inflammatory markers (IL-2 and anti-HSP60) are associated with an increased CAC at baseline and follow-up in healthy asymptomatic adults. Future studies should be carried out to assess its association with early development of atherosclerosis.

Original languageEnglish (US)
Pages (from-to)435-441
Number of pages7
JournalHeart
Volume101
Issue number6
DOIs
StatePublished - Mar 1 2015

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Chaperonin 60
Interleukin-2
Coronary Vessels
Calcium
Atherosclerosis
Dyslipidemias
Coronary Disease
Multivariate Analysis
Tumor Necrosis Factor-alpha
Obesity
Demography
Hypertension

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Damluji, A. A., Ramireddy, A., Al-Damluji, M. S., Marzouka, G. R., Otalvaro, L., Viles Gonzalez, J., ... Myerburg, R. J. (2015). Association between anti-human heat shock protein-60 and interleukin-2 with coronary artery calcium score. Heart, 101(6), 435-441. https://doi.org/10.1136/heartjnl-2014-306649

Association between anti-human heat shock protein-60 and interleukin-2 with coronary artery calcium score. / Damluji, Abdulla A.; Ramireddy, Archana; Al-Damluji, Mohammed S.; Marzouka, George R.; Otalvaro, Lynda; Viles Gonzalez, Juan; Dong, Chunming; Alfonso, Carlos E; Hendel, Robert; Cohen, Mauricio G; Moscucci, Mauro; Bishopric, Nanette; Myerburg, Robert J.

In: Heart, Vol. 101, No. 6, 01.03.2015, p. 435-441.

Research output: Contribution to journalArticle

Damluji, AA, Ramireddy, A, Al-Damluji, MS, Marzouka, GR, Otalvaro, L, Viles Gonzalez, J, Dong, C, Alfonso, CE, Hendel, R, Cohen, MG, Moscucci, M, Bishopric, N & Myerburg, RJ 2015, 'Association between anti-human heat shock protein-60 and interleukin-2 with coronary artery calcium score', Heart, vol. 101, no. 6, pp. 435-441. https://doi.org/10.1136/heartjnl-2014-306649
Damluji AA, Ramireddy A, Al-Damluji MS, Marzouka GR, Otalvaro L, Viles Gonzalez J et al. Association between anti-human heat shock protein-60 and interleukin-2 with coronary artery calcium score. Heart. 2015 Mar 1;101(6):435-441. https://doi.org/10.1136/heartjnl-2014-306649
Damluji, Abdulla A. ; Ramireddy, Archana ; Al-Damluji, Mohammed S. ; Marzouka, George R. ; Otalvaro, Lynda ; Viles Gonzalez, Juan ; Dong, Chunming ; Alfonso, Carlos E ; Hendel, Robert ; Cohen, Mauricio G ; Moscucci, Mauro ; Bishopric, Nanette ; Myerburg, Robert J. / Association between anti-human heat shock protein-60 and interleukin-2 with coronary artery calcium score. In: Heart. 2015 ; Vol. 101, No. 6. pp. 435-441.
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abstract = "Introduction Based upon evidence suggesting that concentrations of anti-heat shock protein-60 (anti-HSP60) and interleukin-2 (IL-2) are associated with atherogenesis, we tested the hypothesis that anti-HSP60 and IL-2 are associated with coronary artery calcium (CAC) score, a marker of subclinical atherosclerosis. Methods We evaluated 998 asymptomatic adults, age 45-84 years, without known coronary disease from the Multi-Ethnic Study of Atherosclerosis (MESA), who had anti-HSP60 measured at baseline. Tertiles of serum anti-HSP60 were evaluated. The associations of IL-2 and anti-HSP60 with CAC were assessed using multivariate analyses, with adjustments for coronary risk factors and Framingham risk score. Results Patients' demographics, diabetes, hypertension, obesity, or dyslipidaemia did not show differences in levels of anti-HSP60. The median (IQR) Framingham risk score was 11 (5 -22), 8 (5-16), and 9 (5-18) for the first, second, and third tertiles, respectively ( p=0.043). IL-2 and tumour necrosis factor α (TNF-α) were associated with increased CAC (IL-2: OR 3.70, p<0.001; TNF-α : OR 4.63, p<0.001). In multivariate regression, the highest tertiles of anti-HSP60 and IL-2 were associated with increased risk of CAC (HSP60 T3: OR 1.49, p=0.022; IL-2: OR 2.49, p<0.001). After adjustment, significant progression of CAC was observed in patients with higher baseline levels of anti-HSP60 (estimate 31.73, p=0.016) and IL-2 (estimate 34.39, p=0.024). Conclusions Increased concentrations of inflammatory markers (IL-2 and anti-HSP60) are associated with an increased CAC at baseline and follow-up in healthy asymptomatic adults. Future studies should be carried out to assess its association with early development of atherosclerosis.",
author = "Damluji, {Abdulla A.} and Archana Ramireddy and Al-Damluji, {Mohammed S.} and Marzouka, {George R.} and Lynda Otalvaro and {Viles Gonzalez}, Juan and Chunming Dong and Alfonso, {Carlos E} and Robert Hendel and Cohen, {Mauricio G} and Mauro Moscucci and Nanette Bishopric and Myerburg, {Robert J}",
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T1 - Association between anti-human heat shock protein-60 and interleukin-2 with coronary artery calcium score

AU - Damluji, Abdulla A.

AU - Ramireddy, Archana

AU - Al-Damluji, Mohammed S.

AU - Marzouka, George R.

AU - Otalvaro, Lynda

AU - Viles Gonzalez, Juan

AU - Dong, Chunming

AU - Alfonso, Carlos E

AU - Hendel, Robert

AU - Cohen, Mauricio G

AU - Moscucci, Mauro

AU - Bishopric, Nanette

AU - Myerburg, Robert J

PY - 2015/3/1

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N2 - Introduction Based upon evidence suggesting that concentrations of anti-heat shock protein-60 (anti-HSP60) and interleukin-2 (IL-2) are associated with atherogenesis, we tested the hypothesis that anti-HSP60 and IL-2 are associated with coronary artery calcium (CAC) score, a marker of subclinical atherosclerosis. Methods We evaluated 998 asymptomatic adults, age 45-84 years, without known coronary disease from the Multi-Ethnic Study of Atherosclerosis (MESA), who had anti-HSP60 measured at baseline. Tertiles of serum anti-HSP60 were evaluated. The associations of IL-2 and anti-HSP60 with CAC were assessed using multivariate analyses, with adjustments for coronary risk factors and Framingham risk score. Results Patients' demographics, diabetes, hypertension, obesity, or dyslipidaemia did not show differences in levels of anti-HSP60. The median (IQR) Framingham risk score was 11 (5 -22), 8 (5-16), and 9 (5-18) for the first, second, and third tertiles, respectively ( p=0.043). IL-2 and tumour necrosis factor α (TNF-α) were associated with increased CAC (IL-2: OR 3.70, p<0.001; TNF-α : OR 4.63, p<0.001). In multivariate regression, the highest tertiles of anti-HSP60 and IL-2 were associated with increased risk of CAC (HSP60 T3: OR 1.49, p=0.022; IL-2: OR 2.49, p<0.001). After adjustment, significant progression of CAC was observed in patients with higher baseline levels of anti-HSP60 (estimate 31.73, p=0.016) and IL-2 (estimate 34.39, p=0.024). Conclusions Increased concentrations of inflammatory markers (IL-2 and anti-HSP60) are associated with an increased CAC at baseline and follow-up in healthy asymptomatic adults. Future studies should be carried out to assess its association with early development of atherosclerosis.

AB - Introduction Based upon evidence suggesting that concentrations of anti-heat shock protein-60 (anti-HSP60) and interleukin-2 (IL-2) are associated with atherogenesis, we tested the hypothesis that anti-HSP60 and IL-2 are associated with coronary artery calcium (CAC) score, a marker of subclinical atherosclerosis. Methods We evaluated 998 asymptomatic adults, age 45-84 years, without known coronary disease from the Multi-Ethnic Study of Atherosclerosis (MESA), who had anti-HSP60 measured at baseline. Tertiles of serum anti-HSP60 were evaluated. The associations of IL-2 and anti-HSP60 with CAC were assessed using multivariate analyses, with adjustments for coronary risk factors and Framingham risk score. Results Patients' demographics, diabetes, hypertension, obesity, or dyslipidaemia did not show differences in levels of anti-HSP60. The median (IQR) Framingham risk score was 11 (5 -22), 8 (5-16), and 9 (5-18) for the first, second, and third tertiles, respectively ( p=0.043). IL-2 and tumour necrosis factor α (TNF-α) were associated with increased CAC (IL-2: OR 3.70, p<0.001; TNF-α : OR 4.63, p<0.001). In multivariate regression, the highest tertiles of anti-HSP60 and IL-2 were associated with increased risk of CAC (HSP60 T3: OR 1.49, p=0.022; IL-2: OR 2.49, p<0.001). After adjustment, significant progression of CAC was observed in patients with higher baseline levels of anti-HSP60 (estimate 31.73, p=0.016) and IL-2 (estimate 34.39, p=0.024). Conclusions Increased concentrations of inflammatory markers (IL-2 and anti-HSP60) are associated with an increased CAC at baseline and follow-up in healthy asymptomatic adults. Future studies should be carried out to assess its association with early development of atherosclerosis.

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