Association between angiotensin-converting enzyme and Alzheimer disease

Lindsay A. Farrer, Tatyana Shcrbatich, Scrgcy A. Kcryanov, Galina I. Korovaitscva, Ehatcrina A. Rogaeva, Svetlana Petruk, Smita Premkumar, Yuri Moliaha, You Qiang Song, York Pei, Christine Sato, Natalya D. Selczncva, Svetlana Voshresenshaya, Vera Golimbct, Sandra Sorbi, Rangcnc Duara, Svetlana Gavrilova, Peter H. St Georgc-Hyslop, Evgeny L. Rogaev

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Abstract

Background: Angiotensin-converting enzyme has been reported to show altered activity in patients with neurologic diseases. An insertion-deletion polymorphism in ACE has recently been linked to heart disease, cerebrovascular disease, and AD. Objective: To determine whether the angiotensin-converting enzyme (ACE) is associated with risk of Alzheimer disease (AD). Methods: We investigated the ACE polymorphism as a potential risk factor for AD in 151 patients with AD and 206 ethnically matched controls from Russia and in 236 patients with AD and 169 controls from North America by means of allele association methods and logistic regression. Results: None of the ACE genotypes was associated with increased susceptibility to AD in the total sample or in subsets stratified by apolipoprotein E gene (APOE) ε4 status. However, the D allele was more frequent among AD cases between ages 66 and 70 years compared with controls in both the Russian (P = .02) and North American (P = .001) datasets. In this age group, the effect of D (odds ratio, 11.2; 95% confidence interval, 2.9- 44.0) appeared to be independent of and equal or greater in magnitude to the effect of APOE ε4 (odds ratio, 7.8; 95% confidence interval, 3.5-7.4). Conclusions: Our results suggest that APOE and ACE genotypes may be independent risk factors for late-onset AD, but the ACE association needs to be confirmed in independent samples in which the time and extent of vascular cofactors can be assessed.

Original languageEnglish
Pages (from-to)210-214
Number of pages5
JournalArchives of Neurology
Volume57
Issue number2
StatePublished - Feb 1 2000
Externally publishedYes

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Peptidyl-Dipeptidase A
Alzheimer Disease
Apolipoprotein E4
Alleles
Odds Ratio
Genotype
Confidence Intervals
Genes
Cerebrovascular Disorders
Alzheimer's Disease
Enzymes
Russia
Apolipoproteins E
North America
Nervous System Diseases
Blood Vessels
Heart Diseases
Age Groups
Logistic Models
Gene

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Farrer, L. A., Shcrbatich, T., Kcryanov, S. A., Korovaitscva, G. I., Rogaeva, E. A., Petruk, S., ... Rogaev, E. L. (2000). Association between angiotensin-converting enzyme and Alzheimer disease. Archives of Neurology, 57(2), 210-214.

Association between angiotensin-converting enzyme and Alzheimer disease. / Farrer, Lindsay A.; Shcrbatich, Tatyana; Kcryanov, Scrgcy A.; Korovaitscva, Galina I.; Rogaeva, Ehatcrina A.; Petruk, Svetlana; Premkumar, Smita; Moliaha, Yuri; Song, You Qiang; Pei, York; Sato, Christine; Selczncva, Natalya D.; Voshresenshaya, Svetlana; Golimbct, Vera; Sorbi, Sandra; Duara, Rangcnc; Gavrilova, Svetlana; St Georgc-Hyslop, Peter H.; Rogaev, Evgeny L.

In: Archives of Neurology, Vol. 57, No. 2, 01.02.2000, p. 210-214.

Research output: Contribution to journalArticle

Farrer, LA, Shcrbatich, T, Kcryanov, SA, Korovaitscva, GI, Rogaeva, EA, Petruk, S, Premkumar, S, Moliaha, Y, Song, YQ, Pei, Y, Sato, C, Selczncva, ND, Voshresenshaya, S, Golimbct, V, Sorbi, S, Duara, R, Gavrilova, S, St Georgc-Hyslop, PH & Rogaev, EL 2000, 'Association between angiotensin-converting enzyme and Alzheimer disease', Archives of Neurology, vol. 57, no. 2, pp. 210-214.
Farrer LA, Shcrbatich T, Kcryanov SA, Korovaitscva GI, Rogaeva EA, Petruk S et al. Association between angiotensin-converting enzyme and Alzheimer disease. Archives of Neurology. 2000 Feb 1;57(2):210-214.
Farrer, Lindsay A. ; Shcrbatich, Tatyana ; Kcryanov, Scrgcy A. ; Korovaitscva, Galina I. ; Rogaeva, Ehatcrina A. ; Petruk, Svetlana ; Premkumar, Smita ; Moliaha, Yuri ; Song, You Qiang ; Pei, York ; Sato, Christine ; Selczncva, Natalya D. ; Voshresenshaya, Svetlana ; Golimbct, Vera ; Sorbi, Sandra ; Duara, Rangcnc ; Gavrilova, Svetlana ; St Georgc-Hyslop, Peter H. ; Rogaev, Evgeny L. / Association between angiotensin-converting enzyme and Alzheimer disease. In: Archives of Neurology. 2000 ; Vol. 57, No. 2. pp. 210-214.
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AU - Shcrbatich, Tatyana

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AU - Korovaitscva, Galina I.

AU - Rogaeva, Ehatcrina A.

AU - Petruk, Svetlana

AU - Premkumar, Smita

AU - Moliaha, Yuri

AU - Song, You Qiang

AU - Pei, York

AU - Sato, Christine

AU - Selczncva, Natalya D.

AU - Voshresenshaya, Svetlana

AU - Golimbct, Vera

AU - Sorbi, Sandra

AU - Duara, Rangcnc

AU - Gavrilova, Svetlana

AU - St Georgc-Hyslop, Peter H.

AU - Rogaev, Evgeny L.

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N2 - Background: Angiotensin-converting enzyme has been reported to show altered activity in patients with neurologic diseases. An insertion-deletion polymorphism in ACE has recently been linked to heart disease, cerebrovascular disease, and AD. Objective: To determine whether the angiotensin-converting enzyme (ACE) is associated with risk of Alzheimer disease (AD). Methods: We investigated the ACE polymorphism as a potential risk factor for AD in 151 patients with AD and 206 ethnically matched controls from Russia and in 236 patients with AD and 169 controls from North America by means of allele association methods and logistic regression. Results: None of the ACE genotypes was associated with increased susceptibility to AD in the total sample or in subsets stratified by apolipoprotein E gene (APOE) ε4 status. However, the D allele was more frequent among AD cases between ages 66 and 70 years compared with controls in both the Russian (P = .02) and North American (P = .001) datasets. In this age group, the effect of D (odds ratio, 11.2; 95% confidence interval, 2.9- 44.0) appeared to be independent of and equal or greater in magnitude to the effect of APOE ε4 (odds ratio, 7.8; 95% confidence interval, 3.5-7.4). Conclusions: Our results suggest that APOE and ACE genotypes may be independent risk factors for late-onset AD, but the ACE association needs to be confirmed in independent samples in which the time and extent of vascular cofactors can be assessed.

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