Association between Alzheimer's disease and a functional polymorphism in the Myeloperoxidase gene

Fiona C. Crawford, Melissa J. Freeman, John A. Schinka, Mark D. Morris, Laila I. Abdullah, Dan Richards, Steven Sevush, Ranjan Duara, Michael J. Mullan

Research output: Contribution to journalArticle

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Abstract

A polymorphism in the Myeloperoxidase gene (MPO) has previously been demonstrated to be associated with gender-specific risk in an Alzheimer's Disease (AD) autopsy sample. We have investigated this polymorphism in our own samples of 226 Caucasian cases and 166 controls and 59 Hispanic cases and 75 controls. In Caucasians we find a significant association between MPO genotype and AD (P = 0.03), although we do not observe any effects of gender or any interaction with the APOE gene. Specifically, the MPO GG genotype contributes a 1.57-fold increased risk for AD. In Hispanics there was no effect of MPO genotype, or of MPO genotype in interaction with age or gender, on diagnosis of AD.

Original languageEnglish
Pages (from-to)456-459
Number of pages4
JournalExperimental Neurology
Volume167
Issue number2
DOIs
StatePublished - Feb 24 2001
Externally publishedYes

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Peroxidase
Alzheimer Disease
Genotype
Genes
Hispanic Americans
Autopsy

ASJC Scopus subject areas

  • Neurology
  • Neuroscience(all)

Cite this

Crawford, F. C., Freeman, M. J., Schinka, J. A., Morris, M. D., Abdullah, L. I., Richards, D., ... Mullan, M. J. (2001). Association between Alzheimer's disease and a functional polymorphism in the Myeloperoxidase gene. Experimental Neurology, 167(2), 456-459. https://doi.org/10.1006/exnr.2000.7560

Association between Alzheimer's disease and a functional polymorphism in the Myeloperoxidase gene. / Crawford, Fiona C.; Freeman, Melissa J.; Schinka, John A.; Morris, Mark D.; Abdullah, Laila I.; Richards, Dan; Sevush, Steven; Duara, Ranjan; Mullan, Michael J.

In: Experimental Neurology, Vol. 167, No. 2, 24.02.2001, p. 456-459.

Research output: Contribution to journalArticle

Crawford, FC, Freeman, MJ, Schinka, JA, Morris, MD, Abdullah, LI, Richards, D, Sevush, S, Duara, R & Mullan, MJ 2001, 'Association between Alzheimer's disease and a functional polymorphism in the Myeloperoxidase gene', Experimental Neurology, vol. 167, no. 2, pp. 456-459. https://doi.org/10.1006/exnr.2000.7560
Crawford FC, Freeman MJ, Schinka JA, Morris MD, Abdullah LI, Richards D et al. Association between Alzheimer's disease and a functional polymorphism in the Myeloperoxidase gene. Experimental Neurology. 2001 Feb 24;167(2):456-459. https://doi.org/10.1006/exnr.2000.7560
Crawford, Fiona C. ; Freeman, Melissa J. ; Schinka, John A. ; Morris, Mark D. ; Abdullah, Laila I. ; Richards, Dan ; Sevush, Steven ; Duara, Ranjan ; Mullan, Michael J. / Association between Alzheimer's disease and a functional polymorphism in the Myeloperoxidase gene. In: Experimental Neurology. 2001 ; Vol. 167, No. 2. pp. 456-459.
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