Assessment of vision-related function in patients with age-related macular degeneration

Paul J. Mackenzie, Tom S. Chang, Ingrid U. Scott, Mark Linder, Dawn Hay, William J. Feuer, Keith Chambers

Research output: Contribution to journalArticle

73 Scopus citations

Abstract

Objective: To investigate the validity of the visual function index (VF-14) in assessing visual function in patients with age-related macular degeneration (AMD). Design: Prospective noncomparative observational case series. Participants: One hundred fifty-nine consecutive patients attending a sole practitioner's academic retinaonly clinic from May 1998 through August 1998 and from May 1999 through August 1999. Main Outcome Measures: Correlations were calculated between the VF-14 scores and the medical outcomes study 36-item short form (SF-36), weighted comorbidity scale, visual acuity and clinical AMD severity (stage), and vision self-assessment scales. Documentation of the severity of macular degeneration was performed by a sole examiner. Results: There was a moderately strong correlation between visual acuity and trouble with vision (r = 0.51), satisfaction with vision (r = -0.50), and overall quality of vision (r = -0.56). A strong correlation was noted between VF-14 score and patients' self-rating of amount of trouble with vision (r = -0.67), satisfaction with vision (r = 0.62), and overall quality of vision (r = 0.67). In comparison, correlations between SF-36 score and patients' self-rating of amount of trouble with vision, satisfaction with vision, and overall quality of vision ranged from r = 0.37 to r = -0.40. Linear regression analysis for the overall study population indicated that AMD severity was not an independently significant predictor of VF-14 score after adjusting for visual acuity. However, among patients with 20/20 vision in the better eye, AMD severity was an independently significant predictor of VF-14 score after adjusting for visual acuity in the worse eye. Conclusions: The VF-14 exhibits a considerable degree of validity as a measure of functional impairment in patients with AMD. Age-related macular degeneration severity was an independently significant predictor of VF-14 score in the group of patients with 20/20 vision in the better eye, but this did not hold true for the overall study population. Age-related macular degeneration is associated with substantial impairment in reported visual function.

Original languageEnglish (US)
Pages (from-to)720-729
Number of pages10
JournalOphthalmology
Volume109
Issue number4
DOIs
StatePublished - Apr 13 2002

ASJC Scopus subject areas

  • Ophthalmology

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    Mackenzie, P. J., Chang, T. S., Scott, I. U., Linder, M., Hay, D., Feuer, W. J., & Chambers, K. (2002). Assessment of vision-related function in patients with age-related macular degeneration. Ophthalmology, 109(4), 720-729. https://doi.org/10.1016/S0161-6420(01)01021-1