Assessment of the biomechanical state of intracranial tissues by dynamic MRI of cerebrospinal fluid pulsations: A phantom study

D. Chu, D. N. Levin, Noam Alperin

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We used a cranial phantom to investigate how intracranial mechanical factors [brain compliance and the resistance to the flow of cerebrospinal fluid (CSF)] affect the way in which CSF pulsations are driven by pulsatile transcranial blood flow. Dynamic phase-contrast magnetic resonance imaging (MRI) was used to measure the transfer function between vascular pulsations and pulsatile response of the CSF below the foramen magnum of the phantom. We found that the coupling between the high frequency components of cervical CSF flow and transcranial blood flow was decreased when the phantom was modified to simulate increased brain compliance and increased resistance to CSF flow.

Original languageEnglish
Pages (from-to)1043-1048
Number of pages6
JournalMagnetic Resonance Imaging
Volume16
Issue number9
DOIs
StatePublished - Nov 1 1998
Externally publishedYes

Fingerprint

cerebrospinal fluid
Cerebrospinal fluid
Magnetic resonance
magnetic resonance
Cerebrospinal Fluid
Magnetic Resonance Imaging
Tissue
Imaging techniques
blood flow
Compliance
fluid flow
brain
Flow of fluids
Brain
Blood
Foramen Magnum
phase contrast
transfer functions
Transfer functions
Blood Vessels

Keywords

  • Brain biomechanics
  • Cerebrospinal fluid
  • Cranial phantom
  • Dynamic MRI
  • Flow imaging

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

Cite this

Assessment of the biomechanical state of intracranial tissues by dynamic MRI of cerebrospinal fluid pulsations : A phantom study. / Chu, D.; Levin, D. N.; Alperin, Noam.

In: Magnetic Resonance Imaging, Vol. 16, No. 9, 01.11.1998, p. 1043-1048.

Research output: Contribution to journalArticle

@article{30a9ca92e30744e9b4c586428268f350,
title = "Assessment of the biomechanical state of intracranial tissues by dynamic MRI of cerebrospinal fluid pulsations: A phantom study",
abstract = "We used a cranial phantom to investigate how intracranial mechanical factors [brain compliance and the resistance to the flow of cerebrospinal fluid (CSF)] affect the way in which CSF pulsations are driven by pulsatile transcranial blood flow. Dynamic phase-contrast magnetic resonance imaging (MRI) was used to measure the transfer function between vascular pulsations and pulsatile response of the CSF below the foramen magnum of the phantom. We found that the coupling between the high frequency components of cervical CSF flow and transcranial blood flow was decreased when the phantom was modified to simulate increased brain compliance and increased resistance to CSF flow.",
keywords = "Brain biomechanics, Cerebrospinal fluid, Cranial phantom, Dynamic MRI, Flow imaging",
author = "D. Chu and Levin, {D. N.} and Noam Alperin",
year = "1998",
month = "11",
day = "1",
doi = "10.1016/S0730-725X(98)00142-8",
language = "English",
volume = "16",
pages = "1043--1048",
journal = "Magnetic Resonance Imaging",
issn = "0730-725X",
publisher = "Elsevier Inc.",
number = "9",

}

TY - JOUR

T1 - Assessment of the biomechanical state of intracranial tissues by dynamic MRI of cerebrospinal fluid pulsations

T2 - A phantom study

AU - Chu, D.

AU - Levin, D. N.

AU - Alperin, Noam

PY - 1998/11/1

Y1 - 1998/11/1

N2 - We used a cranial phantom to investigate how intracranial mechanical factors [brain compliance and the resistance to the flow of cerebrospinal fluid (CSF)] affect the way in which CSF pulsations are driven by pulsatile transcranial blood flow. Dynamic phase-contrast magnetic resonance imaging (MRI) was used to measure the transfer function between vascular pulsations and pulsatile response of the CSF below the foramen magnum of the phantom. We found that the coupling between the high frequency components of cervical CSF flow and transcranial blood flow was decreased when the phantom was modified to simulate increased brain compliance and increased resistance to CSF flow.

AB - We used a cranial phantom to investigate how intracranial mechanical factors [brain compliance and the resistance to the flow of cerebrospinal fluid (CSF)] affect the way in which CSF pulsations are driven by pulsatile transcranial blood flow. Dynamic phase-contrast magnetic resonance imaging (MRI) was used to measure the transfer function between vascular pulsations and pulsatile response of the CSF below the foramen magnum of the phantom. We found that the coupling between the high frequency components of cervical CSF flow and transcranial blood flow was decreased when the phantom was modified to simulate increased brain compliance and increased resistance to CSF flow.

KW - Brain biomechanics

KW - Cerebrospinal fluid

KW - Cranial phantom

KW - Dynamic MRI

KW - Flow imaging

UR - http://www.scopus.com/inward/record.url?scp=0032442646&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032442646&partnerID=8YFLogxK

U2 - 10.1016/S0730-725X(98)00142-8

DO - 10.1016/S0730-725X(98)00142-8

M3 - Article

C2 - 9839988

AN - SCOPUS:0032442646

VL - 16

SP - 1043

EP - 1048

JO - Magnetic Resonance Imaging

JF - Magnetic Resonance Imaging

SN - 0730-725X

IS - 9

ER -