Assessment of the biomechanical state of intracranial tissues by dynamic MRI of cerebrospinal fluid pulsations: A phantom study

D. Chu, D. N. Levin, N. Alperin

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

We used a cranial phantom to investigate how intracranial mechanical factors [brain compliance and the resistance to the flow of cerebrospinal fluid (CSF)] affect the way in which CSF pulsations are driven by pulsatile transcranial blood flow. Dynamic phase-contrast magnetic resonance imaging (MRI) was used to measure the transfer function between vascular pulsations and pulsatile response of the CSF below the foramen magnum of the phantom. We found that the coupling between the high frequency components of cervical CSF flow and transcranial blood flow was decreased when the phantom was modified to simulate increased brain compliance and increased resistance to CSF flow.

Original languageEnglish (US)
Pages (from-to)1043-1048
Number of pages6
JournalMagnetic Resonance Imaging
Volume16
Issue number9
DOIs
StatePublished - Nov 1 1998
Externally publishedYes

Keywords

  • Brain biomechanics
  • Cerebrospinal fluid
  • Cranial phantom
  • Dynamic MRI
  • Flow imaging

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

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