Assessment of surface concentrations in resorbable ocular implants

Controlled drug delivery devices for 5-fluorouracil (5-FU)

Peter J. Milne, Sandrine Gautier, Jean-Marie A Parel, Valerie Jallet

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

The antineoplastic drug 5-fluorouracil (5-fluoro- 2,4,(1H,3H)- pyrimidinedione; 5-FU) has been used to control proliferation of penetrating fibroblasts and to prevent channel closure following glaucoma filtration surgery (trabeculectomy) or laser sclerectomy. Because of the toxicity of the drug, administration of low dosages slowly over time, at the site of the desired treatment, is indicated for optimum efficacy. Repeated injections of low dosages of the drug represent an undesirable intervention and may also result in unwanted toxicity to the corneal epithelium. A suitable biocompatible and resorbable polymer matrix composed of a poly (D,L-lactic-co-glycolic acid: PLGA) has been admixed with varying amounts of 5-FU and cast as shapes suitable for intracorneal implantation. Slow biodegradation of this polymer over a one to two week period has been shown to result in an acceptably slow drug release mechanism. An issue arising during the clinical evaluation of the efficacy of this drug delivery system was how best to quantify the concentration of 5-FU and its distribution spatially in the solid implant. FT-IR and FT-Raman spectroscopies distinguishes between the drug and the polymer matrix and were used to differentiate and quantitate the 5-FU concentration of the implants.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
Pages137-146
Number of pages10
Volume2971
DOIs
StatePublished - 1997
EventOphthalmic Technologies VII - San Jose, CA, United States
Duration: Feb 8 1997Feb 8 1997

Other

OtherOphthalmic Technologies VII
CountryUnited States
CitySan Jose, CA
Period2/8/972/8/97

Fingerprint

Controlled drug delivery
Drug Delivery
Implant
Polymer matrix
Fluorouracil
Toxicity
delivery
Drugs
drugs
Fibroblasts
Biodegradation
Polymers
Surgery
Raman spectroscopy
Efficacy
toxicity
Pharmaceutical Preparations
Acids
Lasers
polymers

Keywords

  • 5-fluorouracil
  • Bioresorbable ocular implant
  • Glaucoma
  • Poly(D,L-lactide)
  • Raman

ASJC Scopus subject areas

  • Applied Mathematics
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

Cite this

Milne, P. J., Gautier, S., Parel, J-M. A., & Jallet, V. (1997). Assessment of surface concentrations in resorbable ocular implants: Controlled drug delivery devices for 5-fluorouracil (5-FU). In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 2971, pp. 137-146) https://doi.org/10.1117/12.275108

Assessment of surface concentrations in resorbable ocular implants : Controlled drug delivery devices for 5-fluorouracil (5-FU). / Milne, Peter J.; Gautier, Sandrine; Parel, Jean-Marie A; Jallet, Valerie.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 2971 1997. p. 137-146.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Milne, PJ, Gautier, S, Parel, J-MA & Jallet, V 1997, Assessment of surface concentrations in resorbable ocular implants: Controlled drug delivery devices for 5-fluorouracil (5-FU). in Proceedings of SPIE - The International Society for Optical Engineering. vol. 2971, pp. 137-146, Ophthalmic Technologies VII, San Jose, CA, United States, 2/8/97. https://doi.org/10.1117/12.275108
Milne PJ, Gautier S, Parel J-MA, Jallet V. Assessment of surface concentrations in resorbable ocular implants: Controlled drug delivery devices for 5-fluorouracil (5-FU). In Proceedings of SPIE - The International Society for Optical Engineering. Vol. 2971. 1997. p. 137-146 https://doi.org/10.1117/12.275108
Milne, Peter J. ; Gautier, Sandrine ; Parel, Jean-Marie A ; Jallet, Valerie. / Assessment of surface concentrations in resorbable ocular implants : Controlled drug delivery devices for 5-fluorouracil (5-FU). Proceedings of SPIE - The International Society for Optical Engineering. Vol. 2971 1997. pp. 137-146
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