Assessment of surface concentrations in resorbable ocular implants: Controlled drug delivery devices for 5-fluorouracil (5-FU)

Peter J. Milne, Sandrine Gautier, Jean Marie A. Parel, Valerie Jallet

Research output: Contribution to journalConference article

3 Scopus citations

Abstract

The antineoplastic drug 5-fluorouracil (5-fluoro- 2,4,(1H,3H)- pyrimidinedione; 5-FU) has been used to control proliferation of penetrating fibroblasts and to prevent channel closure following glaucoma filtration surgery (trabeculectomy) or laser sclerectomy. Because of the toxicity of the drug, administration of low dosages slowly over time, at the site of the desired treatment, is indicated for optimum efficacy. Repeated injections of low dosages of the drug represent an undesirable intervention and may also result in unwanted toxicity to the corneal epithelium. A suitable biocompatible and resorbable polymer matrix composed of a poly (D,L-lactic-co-glycolic acid: PLGA) has been admixed with varying amounts of 5-FU and cast as shapes suitable for intracorneal implantation. Slow biodegradation of this polymer over a one to two week period has been shown to result in an acceptably slow drug release mechanism. An issue arising during the clinical evaluation of the efficacy of this drug delivery system was how best to quantify the concentration of 5-FU and its distribution spatially in the solid implant. FT-IR and FT-Raman spectroscopies distinguishes between the drug and the polymer matrix and were used to differentiate and quantitate the 5-FU concentration of the implants.

Original languageEnglish (US)
Pages (from-to)137-146
Number of pages10
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume2971
DOIs
StatePublished - Dec 1 1997
EventOphthalmic Technologies VII - San Jose, CA, United States
Duration: Feb 8 1997Feb 8 1997

Keywords

  • 5-fluorouracil
  • Bioresorbable ocular implant
  • Glaucoma
  • Poly(D,L-lactide)
  • Raman

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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