Assessment of single isocenter linear accelerator radiosurgery for metastases and base of skull lesions

Elizabeth Bossart, Eric A. Mellon, Irene Monterroso, Nagy Elsayyad, Tejan Diwanji, Stuart Samuels, Nesrin Dogan

Research output: Contribution to journalArticlepeer-review


Background: Newer technology for stereotactic radiosurgery (SRS) should be assessed for different multi-leaf collimators (MLC). Objective: Assess plan quality of an automated, frameless, linear accelerator based (linac) planning and delivery system (HyperArc) for SRS using both standard MLC (SMLC) and high definition MLC (HDMLC) compared to a cobalt-60 based SRS system (Gamma Knife, GK). Methods: We re-planned twenty GK Perfexion-treated SRS patients (27 lesions) for HyperArc using SMLC and HDMLC. We assessed plan quality using the following metrics: gradient index (GI), Paddick and RTOG conformity indices (CIPaddick, CIRTOG), volume receiving half of prescription isodose (PIVhalf) and maximum dose to 0.03 cc for brainstem, optic chiasm and optic nerves, and V12Gy for brain-GTV. Results: Linac plans had better conformity with HDMLC being most conformal. GK exhibited better GI. PIVhalf demonstrated no statistically significant difference between HDMLC and GK, and SMLC was nominally worse than GK. Mean PIVhalf was generally 0.85 cc larger for SMLC than HDMLC. For TV > 1.0 cc, the relative differences in CIRTOG, GI, and PIVhalf for SMLC vs. HDMLC were less than 21%. For TV less than < 1.0 cc, there were more obvious relative differences for SMLC vs. HDMLC in CIRTOG (mean 146%, max 700%), GI (mean 49%, max 162%), and PIVhalf (mean 77%, max 522%). Organ at risk doses were met in all plans. Conclusions: New linac-based plans positively compare to GK plans overall. HDMLC should be strongly considered for treatment of lesions < 1.0 cc given the significant improvements in conformity and PIVhalf over SMLC.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalPhysica Medica
StatePublished - Jan 2021


  • Computer-assisted radiotherapy planning
  • Gamma knife radiosurgery
  • LINAC radiosurgery
  • Metastasis
  • Skull base
  • Stereotactic radiosurgery
  • Targeted radiation therapy

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Physics and Astronomy(all)


Dive into the research topics of 'Assessment of single isocenter linear accelerator radiosurgery for metastases and base of skull lesions'. Together they form a unique fingerprint.

Cite this