Assessment of Rigid Registration Quality Measures in Ultrasound-Guided Radiotherapy

Roozbeh Shams, Yiming Xiao, Francois Hebert, Matthew Abramowitz, Rupert Brooks, Hassan Rivaz

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Image guidance has become the standard of care for patient positioning in radiotherapy, where image registration is often a critical step to help manage patient motion. However, in practice, verification of registration quality is often adversely affected by difficulty in manual inspection of 3-D images and time constraint, thus affecting the therapeutic outcome. Therefore, we proposed to employ both bootstrapping and the supervised learning methods of linear discriminant analysis and random forest to help robustly assess registration quality in ultrasound-guided radiotherapy. We validated both approaches using phantom and real clinical ultrasound images, and showed that both performed well for the task. While learning-based techniques offer better accuracy and shorter evaluation time, bootstrapping requires no prior training and has a higher sensitivity.

Original languageEnglish (US)
Article number8052592
Pages (from-to)428-437
Number of pages10
JournalIEEE Transactions on Medical Imaging
Issue number2
StatePublished - Feb 2018
Externally publishedYes


  • Radiotherapy
  • bootstrapping
  • image registration
  • motion management
  • quality management
  • supervised learning

ASJC Scopus subject areas

  • Software
  • Radiological and Ultrasound Technology
  • Computer Science Applications
  • Electrical and Electronic Engineering


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