Abstract
The realization that dysregulation of the soluble immune mediator network can contribute to the progression of a wide variety of clinical disorders, including neoplasias, has opened up the possibility of designing new forms of therapy and has established the need for accurate methods of detection of immune mediator expression levels in biological fluids and cells.The purpose of this review is to provide a summary of current knowledge and experience in the area of immune mediator expression level assessment from the clinical, basic science, epidemiological, technical, and therapeutic perspectives.
| Original language | English |
|---|---|
| Pages (from-to) | 117-149 |
| Number of pages | 33 |
| Journal | Critical Reviews in Oncogenesis |
| Volume | 6 |
| Issue number | 2 |
| State | Published - Dec 1 1995 |
| Externally published | Yes |
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Keywords
- bioassay
- cytokines
- ELISA
- immunoassay
- interleukin
- polymerase chain reaction
- sensitivity
- soluble receptors
- specifici ty
ASJC Scopus subject areas
- Cancer Research
Cite this
Assessment of immune mediator expression levels in biological fluids and cells : A critical appraisal. / Patarca, R.; Sandler, D.; Walling, J.; Lunn, B. C.; Fletcher, M. A.
In: Critical Reviews in Oncogenesis, Vol. 6, No. 2, 01.12.1995, p. 117-149.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Assessment of immune mediator expression levels in biological fluids and cells
T2 - A critical appraisal
AU - Patarca, R.
AU - Sandler, D.
AU - Walling, J.
AU - Lunn, B. C.
AU - Fletcher, M. A.
PY - 1995/12/1
Y1 - 1995/12/1
N2 - The realization that dysregulation of the soluble immune mediator network can contribute to the progression of a wide variety of clinical disorders, including neoplasias, has opened up the possibility of designing new forms of therapy and has established the need for accurate methods of detection of immune mediator expression levels in biological fluids and cells.The purpose of this review is to provide a summary of current knowledge and experience in the area of immune mediator expression level assessment from the clinical, basic science, epidemiological, technical, and therapeutic perspectives.
AB - The realization that dysregulation of the soluble immune mediator network can contribute to the progression of a wide variety of clinical disorders, including neoplasias, has opened up the possibility of designing new forms of therapy and has established the need for accurate methods of detection of immune mediator expression levels in biological fluids and cells.The purpose of this review is to provide a summary of current knowledge and experience in the area of immune mediator expression level assessment from the clinical, basic science, epidemiological, technical, and therapeutic perspectives.
KW - bioassay
KW - cytokines
KW - ELISA
KW - immunoassay
KW - interleukin
KW - polymerase chain reaction
KW - sensitivity
KW - soluble receptors
KW - specifici ty
UR - http://www.scopus.com/inward/record.url?scp=0029548495&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029548495&partnerID=8YFLogxK
M3 - Article
VL - 6
SP - 117
EP - 149
JO - Critical Reviews in Oncogenesis
JF - Critical Reviews in Oncogenesis
SN - 0893-9675
IS - 2
ER -