Assessment of immune mediator expression levels in biological fluids and cells: A critical appraisal

R. Patarca, D. Sandler, J. Walling, B. C. Lunn, M. A. Fletcher

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The realization that dysregulation of the soluble immune mediator network can contribute to the progression of a wide variety of clinical disorders, including neoplasias, has opened up the possibility of designing new forms of therapy and has established the need for accurate methods of detection of immune mediator expression levels in biological fluids and cells.The purpose of this review is to provide a summary of current knowledge and experience in the area of immune mediator expression level assessment from the clinical, basic science, epidemiological, technical, and therapeutic perspectives.

Original languageEnglish
Pages (from-to)117-149
Number of pages33
JournalCritical Reviews in Oncogenesis
Volume6
Issue number2
StatePublished - Dec 1 1995
Externally publishedYes

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Keywords

  • bioassay
  • cytokines
  • ELISA
  • immunoassay
  • interleukin
  • polymerase chain reaction
  • sensitivity
  • soluble receptors
  • specifici ty

ASJC Scopus subject areas

  • Cancer Research

Cite this

Patarca, R., Sandler, D., Walling, J., Lunn, B. C., & Fletcher, M. A. (1995). Assessment of immune mediator expression levels in biological fluids and cells: A critical appraisal. Critical Reviews in Oncogenesis, 6(2), 117-149.