Assessment of different IMRT boost delivery methods on target coverage and normal-tissue sparing

Nesrin Dogan, Stephanie King, Bahman Emami, Najeeb Mohideen, Nena Mirkovic, Leonid B. Leybovich, Anil Sethi

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

Purpose: Because of biologic, medical, and sometimes logistic reasons, patients may be treated with 3D conformal therapy or intensity-modulated radiation therapy (IMRT) for the initial treatment volume (PTV1) followed by a sequential IMRT boost dose delivered to the boost volume (PTV 2). In some patients, both PTV1 and PTV2 may be simultaneously treated by IMRT (simultaneous integrated boost technique). The purpose of this work was to assess the sequential and simultaneous integrated boost IMRT delivery techniques on target coverage and normal-tissue sparing. Methods and Materials: Fifteen patients with head-and-neck (H&N), lung, and prostate cancer were selected for this comparative study. Each site included 5 patients. In all patients, the target consisted of PTV1 and PTV2. The prescription doses to PTV1 and PTV 2 were 46 Gy and 66 Gy (H&N cases), 45 Gy and 66.6 Gy (lung cases), 50 Gy and 78 Gy (prostate cases), respectively. The critical structures included the following: spinal cord, parotid glands, and brainstem (H&N structures); spinal cord, esophagus, lungs, and heart (lung structures); and bladder, rectum, femurs (prostate structures). For all cases, three IMRT plans were created: (1) 3D conformal therapy to PTV1 followed by sequential IMRT boost to PTV2 (sequential-IMRT1), (2) IMRT to PTV1 followed by sequential IMRT boost to PTV2 (sequential-IMRT2), and (3) Simultaneous integrated IMRT boost to both PTV1 and PTV2 (SIB-IMRT). The treatment plans were compared in terms of their dose-volume histograms, target volume covered by 100% of the prescription dose (D100%), and maximum and mean structure doses (Dmax and Dmean). Results: H&N cases: SIB-IMRT produced better sparing of both parotids than sequential-IMRT 1, although sequential-IMRT2 also provided adequate parotid sparing. On average, the mean cord dose for sequential-IMRT1 was 29 Gy. The mean cord dose was reduced to ∼20 Gy with both sequential-IMRT2 and SIB-IMRT. Prostate cases: The volume of rectum receiving 70 Gy or more (V>70 Gy) was reduced to 18.6 Gy with SIB-IMRT from 22.2 Gy with sequential-IMRT2. SIB-IMRT reduced the mean doses to both bladder and rectum by ∼10% and ∼7%, respectively, as compared to sequential-IMRT2. The mean left and right femur doses with SIB-IMRT were ∼32% lower than obtained with sequential-IMRT 1. Lung cases: The mean heart dose was reduced by ∼33% with SIB-IMRT as compared to sequential-IMRT1. The mean esophagus dose was also reduced by ∼10% using SIB-IMRT as compared to sequential-IMRT 1. The percentage of the lung volume receiving 20 Gy (V20 Gy) was reduced to 26% by SIB-IMRT from 30.6% with sequential-IMRT 1. Conclusions: For equal PTV coverage, both sequential-IMRT techniques demonstrated moderately improved sparing of the critical structures. SIB-IMRT, however, markedly reduced doses to the critical structures for most of the cases considered in this study. The conformality of the SIB-IMRT plans was also much superior to that obtained with both sequential-IMRT techniques. The improved conformality gained with SIB-IMRT may suggest that the dose to nontarget tissues will be lower.

Original languageEnglish (US)
Pages (from-to)1480-1491
Number of pages12
JournalInternational Journal of Radiation Oncology Biology Physics
Volume57
Issue number5
DOIs
StatePublished - Dec 1 2003
Externally publishedYes

Fingerprint

acceleration (physics)
radiation therapy
delivery
Radiotherapy
dosage
lungs
rectum
Lung
Rectum
esophagus
Prostate
femur
spinal cord
bladder
Femur
Esophagus
Prescriptions
therapy
Spinal Cord
Urinary Bladder

Keywords

  • Intensity modulated radiotherapy (IMRT)
  • Sequential IMRT
  • Simultaneous integrated boost

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Assessment of different IMRT boost delivery methods on target coverage and normal-tissue sparing. / Dogan, Nesrin; King, Stephanie; Emami, Bahman; Mohideen, Najeeb; Mirkovic, Nena; Leybovich, Leonid B.; Sethi, Anil.

In: International Journal of Radiation Oncology Biology Physics, Vol. 57, No. 5, 01.12.2003, p. 1480-1491.

Research output: Contribution to journalArticle

Dogan, Nesrin ; King, Stephanie ; Emami, Bahman ; Mohideen, Najeeb ; Mirkovic, Nena ; Leybovich, Leonid B. ; Sethi, Anil. / Assessment of different IMRT boost delivery methods on target coverage and normal-tissue sparing. In: International Journal of Radiation Oncology Biology Physics. 2003 ; Vol. 57, No. 5. pp. 1480-1491.
@article{d8019610172740da9011e67600eac413,
title = "Assessment of different IMRT boost delivery methods on target coverage and normal-tissue sparing",
abstract = "Purpose: Because of biologic, medical, and sometimes logistic reasons, patients may be treated with 3D conformal therapy or intensity-modulated radiation therapy (IMRT) for the initial treatment volume (PTV1) followed by a sequential IMRT boost dose delivered to the boost volume (PTV 2). In some patients, both PTV1 and PTV2 may be simultaneously treated by IMRT (simultaneous integrated boost technique). The purpose of this work was to assess the sequential and simultaneous integrated boost IMRT delivery techniques on target coverage and normal-tissue sparing. Methods and Materials: Fifteen patients with head-and-neck (H&N), lung, and prostate cancer were selected for this comparative study. Each site included 5 patients. In all patients, the target consisted of PTV1 and PTV2. The prescription doses to PTV1 and PTV 2 were 46 Gy and 66 Gy (H&N cases), 45 Gy and 66.6 Gy (lung cases), 50 Gy and 78 Gy (prostate cases), respectively. The critical structures included the following: spinal cord, parotid glands, and brainstem (H&N structures); spinal cord, esophagus, lungs, and heart (lung structures); and bladder, rectum, femurs (prostate structures). For all cases, three IMRT plans were created: (1) 3D conformal therapy to PTV1 followed by sequential IMRT boost to PTV2 (sequential-IMRT1), (2) IMRT to PTV1 followed by sequential IMRT boost to PTV2 (sequential-IMRT2), and (3) Simultaneous integrated IMRT boost to both PTV1 and PTV2 (SIB-IMRT). The treatment plans were compared in terms of their dose-volume histograms, target volume covered by 100{\%} of the prescription dose (D100{\%}), and maximum and mean structure doses (Dmax and Dmean). Results: H&N cases: SIB-IMRT produced better sparing of both parotids than sequential-IMRT 1, although sequential-IMRT2 also provided adequate parotid sparing. On average, the mean cord dose for sequential-IMRT1 was 29 Gy. The mean cord dose was reduced to ∼20 Gy with both sequential-IMRT2 and SIB-IMRT. Prostate cases: The volume of rectum receiving 70 Gy or more (V>70 Gy) was reduced to 18.6 Gy with SIB-IMRT from 22.2 Gy with sequential-IMRT2. SIB-IMRT reduced the mean doses to both bladder and rectum by ∼10{\%} and ∼7{\%}, respectively, as compared to sequential-IMRT2. The mean left and right femur doses with SIB-IMRT were ∼32{\%} lower than obtained with sequential-IMRT 1. Lung cases: The mean heart dose was reduced by ∼33{\%} with SIB-IMRT as compared to sequential-IMRT1. The mean esophagus dose was also reduced by ∼10{\%} using SIB-IMRT as compared to sequential-IMRT 1. The percentage of the lung volume receiving 20 Gy (V20 Gy) was reduced to 26{\%} by SIB-IMRT from 30.6{\%} with sequential-IMRT 1. Conclusions: For equal PTV coverage, both sequential-IMRT techniques demonstrated moderately improved sparing of the critical structures. SIB-IMRT, however, markedly reduced doses to the critical structures for most of the cases considered in this study. The conformality of the SIB-IMRT plans was also much superior to that obtained with both sequential-IMRT techniques. The improved conformality gained with SIB-IMRT may suggest that the dose to nontarget tissues will be lower.",
keywords = "Intensity modulated radiotherapy (IMRT), Sequential IMRT, Simultaneous integrated boost",
author = "Nesrin Dogan and Stephanie King and Bahman Emami and Najeeb Mohideen and Nena Mirkovic and Leybovich, {Leonid B.} and Anil Sethi",
year = "2003",
month = "12",
day = "1",
doi = "10.1016/S0360-3016(03)01569-4",
language = "English (US)",
volume = "57",
pages = "1480--1491",
journal = "International Journal of Radiation Oncology Biology Physics",
issn = "0360-3016",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Assessment of different IMRT boost delivery methods on target coverage and normal-tissue sparing

AU - Dogan, Nesrin

AU - King, Stephanie

AU - Emami, Bahman

AU - Mohideen, Najeeb

AU - Mirkovic, Nena

AU - Leybovich, Leonid B.

AU - Sethi, Anil

PY - 2003/12/1

Y1 - 2003/12/1

N2 - Purpose: Because of biologic, medical, and sometimes logistic reasons, patients may be treated with 3D conformal therapy or intensity-modulated radiation therapy (IMRT) for the initial treatment volume (PTV1) followed by a sequential IMRT boost dose delivered to the boost volume (PTV 2). In some patients, both PTV1 and PTV2 may be simultaneously treated by IMRT (simultaneous integrated boost technique). The purpose of this work was to assess the sequential and simultaneous integrated boost IMRT delivery techniques on target coverage and normal-tissue sparing. Methods and Materials: Fifteen patients with head-and-neck (H&N), lung, and prostate cancer were selected for this comparative study. Each site included 5 patients. In all patients, the target consisted of PTV1 and PTV2. The prescription doses to PTV1 and PTV 2 were 46 Gy and 66 Gy (H&N cases), 45 Gy and 66.6 Gy (lung cases), 50 Gy and 78 Gy (prostate cases), respectively. The critical structures included the following: spinal cord, parotid glands, and brainstem (H&N structures); spinal cord, esophagus, lungs, and heart (lung structures); and bladder, rectum, femurs (prostate structures). For all cases, three IMRT plans were created: (1) 3D conformal therapy to PTV1 followed by sequential IMRT boost to PTV2 (sequential-IMRT1), (2) IMRT to PTV1 followed by sequential IMRT boost to PTV2 (sequential-IMRT2), and (3) Simultaneous integrated IMRT boost to both PTV1 and PTV2 (SIB-IMRT). The treatment plans were compared in terms of their dose-volume histograms, target volume covered by 100% of the prescription dose (D100%), and maximum and mean structure doses (Dmax and Dmean). Results: H&N cases: SIB-IMRT produced better sparing of both parotids than sequential-IMRT 1, although sequential-IMRT2 also provided adequate parotid sparing. On average, the mean cord dose for sequential-IMRT1 was 29 Gy. The mean cord dose was reduced to ∼20 Gy with both sequential-IMRT2 and SIB-IMRT. Prostate cases: The volume of rectum receiving 70 Gy or more (V>70 Gy) was reduced to 18.6 Gy with SIB-IMRT from 22.2 Gy with sequential-IMRT2. SIB-IMRT reduced the mean doses to both bladder and rectum by ∼10% and ∼7%, respectively, as compared to sequential-IMRT2. The mean left and right femur doses with SIB-IMRT were ∼32% lower than obtained with sequential-IMRT 1. Lung cases: The mean heart dose was reduced by ∼33% with SIB-IMRT as compared to sequential-IMRT1. The mean esophagus dose was also reduced by ∼10% using SIB-IMRT as compared to sequential-IMRT 1. The percentage of the lung volume receiving 20 Gy (V20 Gy) was reduced to 26% by SIB-IMRT from 30.6% with sequential-IMRT 1. Conclusions: For equal PTV coverage, both sequential-IMRT techniques demonstrated moderately improved sparing of the critical structures. SIB-IMRT, however, markedly reduced doses to the critical structures for most of the cases considered in this study. The conformality of the SIB-IMRT plans was also much superior to that obtained with both sequential-IMRT techniques. The improved conformality gained with SIB-IMRT may suggest that the dose to nontarget tissues will be lower.

AB - Purpose: Because of biologic, medical, and sometimes logistic reasons, patients may be treated with 3D conformal therapy or intensity-modulated radiation therapy (IMRT) for the initial treatment volume (PTV1) followed by a sequential IMRT boost dose delivered to the boost volume (PTV 2). In some patients, both PTV1 and PTV2 may be simultaneously treated by IMRT (simultaneous integrated boost technique). The purpose of this work was to assess the sequential and simultaneous integrated boost IMRT delivery techniques on target coverage and normal-tissue sparing. Methods and Materials: Fifteen patients with head-and-neck (H&N), lung, and prostate cancer were selected for this comparative study. Each site included 5 patients. In all patients, the target consisted of PTV1 and PTV2. The prescription doses to PTV1 and PTV 2 were 46 Gy and 66 Gy (H&N cases), 45 Gy and 66.6 Gy (lung cases), 50 Gy and 78 Gy (prostate cases), respectively. The critical structures included the following: spinal cord, parotid glands, and brainstem (H&N structures); spinal cord, esophagus, lungs, and heart (lung structures); and bladder, rectum, femurs (prostate structures). For all cases, three IMRT plans were created: (1) 3D conformal therapy to PTV1 followed by sequential IMRT boost to PTV2 (sequential-IMRT1), (2) IMRT to PTV1 followed by sequential IMRT boost to PTV2 (sequential-IMRT2), and (3) Simultaneous integrated IMRT boost to both PTV1 and PTV2 (SIB-IMRT). The treatment plans were compared in terms of their dose-volume histograms, target volume covered by 100% of the prescription dose (D100%), and maximum and mean structure doses (Dmax and Dmean). Results: H&N cases: SIB-IMRT produced better sparing of both parotids than sequential-IMRT 1, although sequential-IMRT2 also provided adequate parotid sparing. On average, the mean cord dose for sequential-IMRT1 was 29 Gy. The mean cord dose was reduced to ∼20 Gy with both sequential-IMRT2 and SIB-IMRT. Prostate cases: The volume of rectum receiving 70 Gy or more (V>70 Gy) was reduced to 18.6 Gy with SIB-IMRT from 22.2 Gy with sequential-IMRT2. SIB-IMRT reduced the mean doses to both bladder and rectum by ∼10% and ∼7%, respectively, as compared to sequential-IMRT2. The mean left and right femur doses with SIB-IMRT were ∼32% lower than obtained with sequential-IMRT 1. Lung cases: The mean heart dose was reduced by ∼33% with SIB-IMRT as compared to sequential-IMRT1. The mean esophagus dose was also reduced by ∼10% using SIB-IMRT as compared to sequential-IMRT 1. The percentage of the lung volume receiving 20 Gy (V20 Gy) was reduced to 26% by SIB-IMRT from 30.6% with sequential-IMRT 1. Conclusions: For equal PTV coverage, both sequential-IMRT techniques demonstrated moderately improved sparing of the critical structures. SIB-IMRT, however, markedly reduced doses to the critical structures for most of the cases considered in this study. The conformality of the SIB-IMRT plans was also much superior to that obtained with both sequential-IMRT techniques. The improved conformality gained with SIB-IMRT may suggest that the dose to nontarget tissues will be lower.

KW - Intensity modulated radiotherapy (IMRT)

KW - Sequential IMRT

KW - Simultaneous integrated boost

UR - http://www.scopus.com/inward/record.url?scp=0344394974&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0344394974&partnerID=8YFLogxK

U2 - 10.1016/S0360-3016(03)01569-4

DO - 10.1016/S0360-3016(03)01569-4

M3 - Article

VL - 57

SP - 1480

EP - 1491

JO - International Journal of Radiation Oncology Biology Physics

JF - International Journal of Radiation Oncology Biology Physics

SN - 0360-3016

IS - 5

ER -