Assessment of Diastolic Function in Hypertrophic Cardiomyopathy by Computed Tomography–Derived Analysis of Left Ventricular Filling

Itai Ghersin, Eduard Ghersin, Sobhi Abadi, Jennifer E. Runco Therrien, Tanyanan Tanawuttiwat, Doron Aronson, Jonathan Lessick

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: Hypertrophic cardiomyopathy (HCM) is characterized by diastolic dysfunction, which is difficult to assess by noninvasive methods. We hypothesized that measurement of simultaneous left ventricular (LV) and left atrial (LA) volume changes by cardiac computed tomography would be useful in the assessment of diastolic function in HCM. METHODS: We studied 21 patients with HCM and 21 age-matched controls. The LA and LV volumes were calculated and early and late diastolic volume changes derived. RESULTS: The HCM patients had significantly larger LA volumes and reduced LA total emptying fraction (30 ± 7% vs 42 ± 6%; P < 0.0001). Conduit volume was increased (30 ± 6 vs 22 ± 4 mL/m; P < 0.0001) and contributed a significantly higher proportion of total LV diastolic filling, suggesting that passive filling of the LV compensates for LA dysfunction, but at the expense of increased pulmonary filling pressure. CONCLUSIONS: This study suggests that simultaneous depiction of computed tomography–derived LV and LA volume changes can characterize diastolic dysfunction in HCM.

Original languageEnglish (US)
JournalJournal of Computer Assisted Tomography
DOIs
StateAccepted/In press - Oct 29 2016

Fingerprint

Hypertrophic Cardiomyopathy
Cardiac Volume
Tomography
Pressure
Lung

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Assessment of Diastolic Function in Hypertrophic Cardiomyopathy by Computed Tomography–Derived Analysis of Left Ventricular Filling. / Ghersin, Itai; Ghersin, Eduard; Abadi, Sobhi; Runco Therrien, Jennifer E.; Tanawuttiwat, Tanyanan; Aronson, Doron; Lessick, Jonathan.

In: Journal of Computer Assisted Tomography, 29.10.2016.

Research output: Contribution to journalArticle

Ghersin, Itai ; Ghersin, Eduard ; Abadi, Sobhi ; Runco Therrien, Jennifer E. ; Tanawuttiwat, Tanyanan ; Aronson, Doron ; Lessick, Jonathan. / Assessment of Diastolic Function in Hypertrophic Cardiomyopathy by Computed Tomography–Derived Analysis of Left Ventricular Filling. In: Journal of Computer Assisted Tomography. 2016.
@article{fb8b5281853f49aa8341b97c3959f997,
title = "Assessment of Diastolic Function in Hypertrophic Cardiomyopathy by Computed Tomography–Derived Analysis of Left Ventricular Filling",
abstract = "OBJECTIVES: Hypertrophic cardiomyopathy (HCM) is characterized by diastolic dysfunction, which is difficult to assess by noninvasive methods. We hypothesized that measurement of simultaneous left ventricular (LV) and left atrial (LA) volume changes by cardiac computed tomography would be useful in the assessment of diastolic function in HCM. METHODS: We studied 21 patients with HCM and 21 age-matched controls. The LA and LV volumes were calculated and early and late diastolic volume changes derived. RESULTS: The HCM patients had significantly larger LA volumes and reduced LA total emptying fraction (30 ± 7{\%} vs 42 ± 6{\%}; P < 0.0001). Conduit volume was increased (30 ± 6 vs 22 ± 4 mL/m; P < 0.0001) and contributed a significantly higher proportion of total LV diastolic filling, suggesting that passive filling of the LV compensates for LA dysfunction, but at the expense of increased pulmonary filling pressure. CONCLUSIONS: This study suggests that simultaneous depiction of computed tomography–derived LV and LA volume changes can characterize diastolic dysfunction in HCM.",
author = "Itai Ghersin and Eduard Ghersin and Sobhi Abadi and {Runco Therrien}, {Jennifer E.} and Tanyanan Tanawuttiwat and Doron Aronson and Jonathan Lessick",
year = "2016",
month = "10",
day = "29",
doi = "10.1097/RCT.0000000000000533",
language = "English (US)",
journal = "Journal of Computer Assisted Tomography",
issn = "0363-8715",
publisher = "Lippincott Williams and Wilkins",

}

TY - JOUR

T1 - Assessment of Diastolic Function in Hypertrophic Cardiomyopathy by Computed Tomography–Derived Analysis of Left Ventricular Filling

AU - Ghersin, Itai

AU - Ghersin, Eduard

AU - Abadi, Sobhi

AU - Runco Therrien, Jennifer E.

AU - Tanawuttiwat, Tanyanan

AU - Aronson, Doron

AU - Lessick, Jonathan

PY - 2016/10/29

Y1 - 2016/10/29

N2 - OBJECTIVES: Hypertrophic cardiomyopathy (HCM) is characterized by diastolic dysfunction, which is difficult to assess by noninvasive methods. We hypothesized that measurement of simultaneous left ventricular (LV) and left atrial (LA) volume changes by cardiac computed tomography would be useful in the assessment of diastolic function in HCM. METHODS: We studied 21 patients with HCM and 21 age-matched controls. The LA and LV volumes were calculated and early and late diastolic volume changes derived. RESULTS: The HCM patients had significantly larger LA volumes and reduced LA total emptying fraction (30 ± 7% vs 42 ± 6%; P < 0.0001). Conduit volume was increased (30 ± 6 vs 22 ± 4 mL/m; P < 0.0001) and contributed a significantly higher proportion of total LV diastolic filling, suggesting that passive filling of the LV compensates for LA dysfunction, but at the expense of increased pulmonary filling pressure. CONCLUSIONS: This study suggests that simultaneous depiction of computed tomography–derived LV and LA volume changes can characterize diastolic dysfunction in HCM.

AB - OBJECTIVES: Hypertrophic cardiomyopathy (HCM) is characterized by diastolic dysfunction, which is difficult to assess by noninvasive methods. We hypothesized that measurement of simultaneous left ventricular (LV) and left atrial (LA) volume changes by cardiac computed tomography would be useful in the assessment of diastolic function in HCM. METHODS: We studied 21 patients with HCM and 21 age-matched controls. The LA and LV volumes were calculated and early and late diastolic volume changes derived. RESULTS: The HCM patients had significantly larger LA volumes and reduced LA total emptying fraction (30 ± 7% vs 42 ± 6%; P < 0.0001). Conduit volume was increased (30 ± 6 vs 22 ± 4 mL/m; P < 0.0001) and contributed a significantly higher proportion of total LV diastolic filling, suggesting that passive filling of the LV compensates for LA dysfunction, but at the expense of increased pulmonary filling pressure. CONCLUSIONS: This study suggests that simultaneous depiction of computed tomography–derived LV and LA volume changes can characterize diastolic dysfunction in HCM.

UR - http://www.scopus.com/inward/record.url?scp=84992723775&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84992723775&partnerID=8YFLogxK

U2 - 10.1097/RCT.0000000000000533

DO - 10.1097/RCT.0000000000000533

M3 - Article

C2 - 27798446

AN - SCOPUS:84992723775

JO - Journal of Computer Assisted Tomography

JF - Journal of Computer Assisted Tomography

SN - 0363-8715

ER -