Assessment of cerebrospinal fluid outflow resistance

Anders Eklund, Peter Smielewski, Iain Chambers, Noam Alperin, Jan Malm, Marek Czosnyka, Anthony Marmarou

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

The brain and the spinal cord are contained in a cavity and are surrounded by cerebrospinal fluid (CSF), which provides physical support for the brain and a cushion against external pressure. Hydrocephalus is a disease, associated with disturbances in the CSF dynamics, which can be surgically treated by inserting a shunt or third ventriculostomy. This review describes the physiological background, modeling and mathematics, and the investigational methods for determining the CSF dynamic properties, with specific focus on the CSF outflow resistance, Rout. A model of the cerebrospinal fluid dynamic system, with a pressure-independent Rout, a pressure-dependent compliance and a constant formation rate of CSF is widely accepted. Using mathematical expressions calculated from the model, along with active infusion of artificial CSF and observation of corresponding change in ICP allows measurements of CSF dynamics. Distinction between normal pressure hydrocephalus and differential diagnoses, prediction of clinical response to shunting and the possibility of assessment of shunt function in vivo are the three most important applications of infusion studies in clinical practice.

Original languageEnglish
Pages (from-to)719-735
Number of pages17
JournalMedical and Biological Engineering and Computing
Volume45
Issue number8
DOIs
StatePublished - Aug 1 2007
Externally publishedYes

Fingerprint

Cerebrospinal fluid
Cerebrospinal Fluid
Hydrodynamics
Fluid dynamics
Pressure
Brain
Ventriculostomy
Normal Pressure Hydrocephalus
Mathematics
Hydrocephalus
Compliance
Spinal Cord
Dynamical systems
Differential Diagnosis
Observation

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics
  • Health Information Management
  • Computer Science Applications
  • Computational Theory and Mathematics

Cite this

Eklund, A., Smielewski, P., Chambers, I., Alperin, N., Malm, J., Czosnyka, M., & Marmarou, A. (2007). Assessment of cerebrospinal fluid outflow resistance. Medical and Biological Engineering and Computing, 45(8), 719-735. https://doi.org/10.1007/s11517-007-0199-5

Assessment of cerebrospinal fluid outflow resistance. / Eklund, Anders; Smielewski, Peter; Chambers, Iain; Alperin, Noam; Malm, Jan; Czosnyka, Marek; Marmarou, Anthony.

In: Medical and Biological Engineering and Computing, Vol. 45, No. 8, 01.08.2007, p. 719-735.

Research output: Contribution to journalArticle

Eklund, A, Smielewski, P, Chambers, I, Alperin, N, Malm, J, Czosnyka, M & Marmarou, A 2007, 'Assessment of cerebrospinal fluid outflow resistance', Medical and Biological Engineering and Computing, vol. 45, no. 8, pp. 719-735. https://doi.org/10.1007/s11517-007-0199-5
Eklund, Anders ; Smielewski, Peter ; Chambers, Iain ; Alperin, Noam ; Malm, Jan ; Czosnyka, Marek ; Marmarou, Anthony. / Assessment of cerebrospinal fluid outflow resistance. In: Medical and Biological Engineering and Computing. 2007 ; Vol. 45, No. 8. pp. 719-735.
@article{bd6a9770ebaa4b3a9ae687368bc96c61,
title = "Assessment of cerebrospinal fluid outflow resistance",
abstract = "The brain and the spinal cord are contained in a cavity and are surrounded by cerebrospinal fluid (CSF), which provides physical support for the brain and a cushion against external pressure. Hydrocephalus is a disease, associated with disturbances in the CSF dynamics, which can be surgically treated by inserting a shunt or third ventriculostomy. This review describes the physiological background, modeling and mathematics, and the investigational methods for determining the CSF dynamic properties, with specific focus on the CSF outflow resistance, Rout. A model of the cerebrospinal fluid dynamic system, with a pressure-independent Rout, a pressure-dependent compliance and a constant formation rate of CSF is widely accepted. Using mathematical expressions calculated from the model, along with active infusion of artificial CSF and observation of corresponding change in ICP allows measurements of CSF dynamics. Distinction between normal pressure hydrocephalus and differential diagnoses, prediction of clinical response to shunting and the possibility of assessment of shunt function in vivo are the three most important applications of infusion studies in clinical practice.",
author = "Anders Eklund and Peter Smielewski and Iain Chambers and Noam Alperin and Jan Malm and Marek Czosnyka and Anthony Marmarou",
year = "2007",
month = "8",
day = "1",
doi = "10.1007/s11517-007-0199-5",
language = "English",
volume = "45",
pages = "719--735",
journal = "Medical and Biological Engineering and Computing",
issn = "0140-0118",
publisher = "Springer Verlag",
number = "8",

}

TY - JOUR

T1 - Assessment of cerebrospinal fluid outflow resistance

AU - Eklund, Anders

AU - Smielewski, Peter

AU - Chambers, Iain

AU - Alperin, Noam

AU - Malm, Jan

AU - Czosnyka, Marek

AU - Marmarou, Anthony

PY - 2007/8/1

Y1 - 2007/8/1

N2 - The brain and the spinal cord are contained in a cavity and are surrounded by cerebrospinal fluid (CSF), which provides physical support for the brain and a cushion against external pressure. Hydrocephalus is a disease, associated with disturbances in the CSF dynamics, which can be surgically treated by inserting a shunt or third ventriculostomy. This review describes the physiological background, modeling and mathematics, and the investigational methods for determining the CSF dynamic properties, with specific focus on the CSF outflow resistance, Rout. A model of the cerebrospinal fluid dynamic system, with a pressure-independent Rout, a pressure-dependent compliance and a constant formation rate of CSF is widely accepted. Using mathematical expressions calculated from the model, along with active infusion of artificial CSF and observation of corresponding change in ICP allows measurements of CSF dynamics. Distinction between normal pressure hydrocephalus and differential diagnoses, prediction of clinical response to shunting and the possibility of assessment of shunt function in vivo are the three most important applications of infusion studies in clinical practice.

AB - The brain and the spinal cord are contained in a cavity and are surrounded by cerebrospinal fluid (CSF), which provides physical support for the brain and a cushion against external pressure. Hydrocephalus is a disease, associated with disturbances in the CSF dynamics, which can be surgically treated by inserting a shunt or third ventriculostomy. This review describes the physiological background, modeling and mathematics, and the investigational methods for determining the CSF dynamic properties, with specific focus on the CSF outflow resistance, Rout. A model of the cerebrospinal fluid dynamic system, with a pressure-independent Rout, a pressure-dependent compliance and a constant formation rate of CSF is widely accepted. Using mathematical expressions calculated from the model, along with active infusion of artificial CSF and observation of corresponding change in ICP allows measurements of CSF dynamics. Distinction between normal pressure hydrocephalus and differential diagnoses, prediction of clinical response to shunting and the possibility of assessment of shunt function in vivo are the three most important applications of infusion studies in clinical practice.

UR - http://www.scopus.com/inward/record.url?scp=34547644271&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34547644271&partnerID=8YFLogxK

U2 - 10.1007/s11517-007-0199-5

DO - 10.1007/s11517-007-0199-5

M3 - Article

C2 - 17634761

AN - SCOPUS:34547644271

VL - 45

SP - 719

EP - 735

JO - Medical and Biological Engineering and Computing

JF - Medical and Biological Engineering and Computing

SN - 0140-0118

IS - 8

ER -