Assessment of adaptive functioning in huntington's disease

Frederick W. Bylsma, Johannes Rothlind, Michelle R. Hall, Susan E. Folstein, Jason Brandt

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


The Huntington's Disease Activities of Daily Living (HD-ADL) scale is a 17-item informant-completed instrument for rating adaptive functioning in Huntington's disease (HD) patients. To assess the reliability and clinical correlates of the HD-ADL, it was administered along with the Mini-Mental State Exam (MMSE) and Quantified Neurological Exam (QNE) to 93 HD patients. The HD-ADL has high internal consistency (coefficient alpha = 0.91). Principal components factor analysis of the HD-ADL revealed four factors (General Functioning, Domestic Activities, Home Upkeep, and Family Relationships) accounting for 72% of the total variance. MMSE score, motor impairment score, and duration of disease were the best predictors of HD-ADL score. Similar results were obtained in an independent replication sample of patients. The HD-ADL scores correlate with Collusion and Fahn's total functional capacity (TFC) index (r = -0.89). The HD-ADL scale is a reliable and valid instrument for assessing adaptive function in HD patients.

Original languageEnglish (US)
Pages (from-to)183-190
Number of pages8
JournalMovement Disorders
Issue number2
StatePublished - 1993


  • Activities of daily living
  • Huntington's disease
  • Mini-mental state exam
  • Quantified neurological exam

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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