Assessment of adaptive functioning in Huntington's disease

F. W. Bylsma, J. Rothlind, M. R. Hall, S. E. Folstein, J. Brandt

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

The Huntington's Disease Activities of Daily Living (HD-ADL) scale is a 17-item informant-completed instrument for rating adaptive functioning in Huntington's disease (HD) patients. To assess the reliability and clinical correlates of the HD-ADL, it was administered along with the Mini-Mental State Exam (MMSE) and Quantified Neurological Exam (QNE) to 93 HD patients. The HD-ADL has high internal consistency (coefficient alpha = 0.91). Principal components factor analysis of the HD-ADL revealed four factors (General Functioning, Domestic Activities, Home Upkeep, and Family Relationships) accounting for 72% of the total variance. MMSE score, motor impairment score, and duration of disease were the best predictors of HD-ADL score. Similar results were obtained in an independent replication sample of patients. The HD-ADL scores correlate with Collusion and Fahn's total functional capacity (TFC) index (r = -0.89). The HD-ADL scale is a reliable and valid instrument for assessing adaptive function in HD patients.

Original languageEnglish
Pages (from-to)183-190
Number of pages8
JournalMovement Disorders
Volume8
Issue number2
StatePublished - Jan 1 1993

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Huntington Disease
Activities of Daily Living
Family Relations
Principal Component Analysis
Statistical Factor Analysis

Keywords

  • Activities of daily living
  • Huntington's disease
  • Mini-mental state exam
  • Quantified neurological exam

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Bylsma, F. W., Rothlind, J., Hall, M. R., Folstein, S. E., & Brandt, J. (1993). Assessment of adaptive functioning in Huntington's disease. Movement Disorders, 8(2), 183-190.

Assessment of adaptive functioning in Huntington's disease. / Bylsma, F. W.; Rothlind, J.; Hall, M. R.; Folstein, S. E.; Brandt, J.

In: Movement Disorders, Vol. 8, No. 2, 01.01.1993, p. 183-190.

Research output: Contribution to journalArticle

Bylsma, FW, Rothlind, J, Hall, MR, Folstein, SE & Brandt, J 1993, 'Assessment of adaptive functioning in Huntington's disease', Movement Disorders, vol. 8, no. 2, pp. 183-190.
Bylsma FW, Rothlind J, Hall MR, Folstein SE, Brandt J. Assessment of adaptive functioning in Huntington's disease. Movement Disorders. 1993 Jan 1;8(2):183-190.
Bylsma, F. W. ; Rothlind, J. ; Hall, M. R. ; Folstein, S. E. ; Brandt, J. / Assessment of adaptive functioning in Huntington's disease. In: Movement Disorders. 1993 ; Vol. 8, No. 2. pp. 183-190.
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